Molecular mechanisms of hepatopulmonary syndrome

Krynytska, Іnna; Кліщ, І. М.; Birchenko, Inna

doi:10.15407/fz63.03.090

Cited by 5 publications

(2 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Endotoxemia may be caused either directly by the movement of bacteria through the intestinal mucosa or indirectly through the cytokine cascade stimulates vascular endothelial inducible nitric oxide synthase, which increases the production of NO. [28,29] Violation of the enterohepatic barrier as one of the pathological manifestations of enteric insufficiency leads to the emergence of an additional source of endotoxicosis, which closes the vicious circle and causes the occurrence of irreversible lesions of various organs and systems. [30] Strengths and limitations: Experimental research designs are repeatable, and therefore, results can be checked and verified.…”

Section: Discussionmentioning

confidence: 99%

The influence of carrageenan on markers of endogenous intoxication in rats

Marushchak¹,

Krynytska²,

Kopanytsia³

et al. 2017

Natl J Physiol Pharm Pharmacol

View full text Add to dashboard Cite

Background:The growth of the world population and the need to increase food production led to the widespread use of food additives. One of such additives is carrageenan. Potentially negative health effects of carrageenans prompt us to question safety of their widespread use. Aims and Objectives: In this study, we defined the effect of carrageenan (E407) consumption on the main markers of endogenous intoxication in rats. Materials and Methods: Experimental studies were conducted on 72 non-linear, female, white rats weighing 150-180 g. The experimental animals had free access to 0.5% carrageenan solution in drinking water. Control group of animals received pure water. Syndrome of endogenous intoxication was evaluated using measurements of low, medium, and high molecular weight substances in blood plasma, red blood cell suspension, and urine. Results: Our results indicate shift of the markers of intoxication syndrome toward mainly catabolic substances. The results obtained after 1 week of the experiment correspond with phase of partial compensation, characterized by increased concentrations of low and middle molecular weight substances in red blood cells and plasma. After 2 weeks and up to 1 month of the experiment, the predominantly catabolic markers of endogenous intoxication continue to increase in erythrocytes and plasma, indicating a shift to the phase of partial decompensation to systems and organs of detoxification. Conclusion: The consumption of carrageenan with drinking water in concentration of 0.5% was associated with the development of excessive levels of low and middle molecular weight substances with reduced ability of kidneys to excrete toxic products.

show abstract

Section: Discussionmentioning

confidence: 99%

The influence of carrageenan on markers of endogenous intoxication in rats

Marushchak¹,

Krynytska²,

Kopanytsia³

et al. 2017

Natl J Physiol Pharm Pharmacol

View full text Add to dashboard Cite

show abstract

“…В последнее время гематологические лейкоцитарные индексы все чаще используются в медицинской и ветеринарной практике [5,1]. Они показывают состоя-ние гомеостатических систем организма, его способность адаптироваться [8,9] и могут дать дополнительную информацию об интоксикации и состоянии иммунного ответа [5]. Мы не встретили в доступной литературе сведений о лейкоцитарных индексах крови у бройлеров при применении митофена и расчет их ранее не проводили.…”

Section: Introductionunclassified

Effect of mitophen on hematological leukocyte indices of broiler chickens

Gaponova

2021

jour

View full text Add to dashboard Cite

Hematological leukocyte indices provide additional information about intoxication and the state of the immune response and become an alternative to determine a number of immuno-biochemical parameters. The aim of the work is to study the effect of the antioxidant mitophen on the leukocyte indices of blood that characterize the nonspecific reactivity of the organism of broiler chickens. The chickens of the I and III experimental groups were given mitophen daily from the daily age at the rate of 25 and 50 g/t of feed for a month, the II and IV-25 and 50 g/t of feed only in the first and third weeks of the experiment. The control group received the main diet without the drug. The leukocyte indices were determined mathematically by the leukogram. It was found that the use of mitophen significantly increases the index: of shift of blood leukocytes, of the ratio of eosinophils and lymphocytes, and lowers the index of the ratio of lymphocytes and eosinophils, which indicates the positive effect of the drug on the granulocytopoiesis and nonspecific resistance of broiler chickens. At the same time, the use of mitophen significantly reduces index: of immunoreactivity, of the ratio of lymphocytes to monocytes, and pseudoeosinophils to monocytes, which characterizes the positive effect of the antioxidant on monocytopoiesis and nonspecific cellular immunity of the bird body due to monocytes.

show abstract