Molecular Mechanisms Of Drug Action

Coulson, Christopher J.

doi:10.1201/9781482295214

Cited by 20 publications

(15 citation statements)

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“…Similarly, APE showed improvement in sucrose tolerance and caused marked inhibition of glucose uptake by the small intestine. Improvement of sucrose tolerance may be due to -glycosidase inhibitory activity (Coulson, 1995) present in APE. The drug may be competing with sucrose for its substrate, and binds to -glycosidase enzymes, thus leading to inhibition of sucrose digestion (Teixeira et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Antihyperglycemic and hypoglycemic activities ofPhyllanthus debilisaqueous plant extract in mice

Wanniarachchi¹,

Peiris²,

Ratnasooriya³

2009

Pharmaceutical Biology

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Section: Discussionmentioning

confidence: 99%

Antihyperglycemic and hypoglycemic activities ofPhyllanthus debilisaqueous plant extract in mice

Wanniarachchi¹,

Peiris²,

Ratnasooriya³

2009

Pharmaceutical Biology

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“…Ltb4dh is of special interest because NSAIDs are known to inhibit the mammalian biosynthesis of various eicosanoids (e.g. prostaglandins, epoxyeicosatrienoic acids and leukotriene) that play important regulatory and signalling functions, for instance regulation of ion flux [ 14 , 15 ]. As anticipated, use of the NF clarified the response of Ltb4dh to ibuprofen.…”

Section: Introductionmentioning

confidence: 99%

Expression of target and reference genes in Daphnia magna exposed to ibuprofen

et al. 2006

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Background: Transcriptomic techniques are now being applied in ecotoxicology and toxicology to measure the impact of stressors and develop understanding of mechanisms of toxicity. Microarray technology in particular offers the potential to measure thousands of gene responses simultaneously. However, it is important that microarrays responses should be validated, at least initially, using real-time quantitative polymerase chain reaction (QPCR). The accurate measurement of target gene expression requires normalisation to an invariant internal control e.g., total RNA or reference genes. Reference genes are preferable, as they control for variation inherent in the cDNA synthesis and PCR. However, reference gene expression can vary between tissues and experimental conditions, which makes it crucial to validate them prior to application.

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“…It is also a first line ACE inhibitor for in vitro setups [32]. The median inhibitory concentration of captopril is within the nM range, as in previous studies [33][34][35]. This drug has five ligands that can bind to the ACE [34], with the carbonyl group being the most important.…”

mentioning

confidence: 67%

The Potential Angiotensin-Converting Enzyme Inhibitory Activity of Oleanolic Acid in the Hydroethanolic Extract of Crataegus monogyna Jacq

Attard

2006

Natural Product Communications

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The hydroethanolic extract of Crataegus monogyna was studied for its chemical constitution and angiotensin-converting enzyme (ACE) inhibitory activity. The extract contained triterpenic acids, flavonoids and coumarins. The ACE inhibitory activity was studied using captropril, as a control drug, and oleanolic acid, as a constituent of the hydroethanolic extract and a member of the triterpenic acid group. The hydroethanolic extract and oleanolic acid showed higher IC 50 values (335.00 µg/mL and 3.61 µM, respectively) in comparison to captopril (46.9 nM). However, these results indicate the anti-ACE activity of oleanolic acid and the triterpenic acids, which has not been demonstrated earlier for hawthorn extracts. In previous studies, the ACE inhibitory activity of C. monogyna extracts was always attributed to flavonoids and proanthocyanidins.

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Molecular Mechanisms Of Drug Action

Cited by 20 publications

References 0 publications

Antihyperglycemic and hypoglycemic activities ofPhyllanthus debilisaqueous plant extract in mice

Antihyperglycemic and hypoglycemic activities ofPhyllanthus debilisaqueous plant extract in mice

Expression of target and reference genes in Daphnia magna exposed to ibuprofen

The Potential Angiotensin-Converting Enzyme Inhibitory Activity of Oleanolic Acid in the Hydroethanolic Extract of Crataegus monogyna Jacq

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