Molecular mechanisms of cyclic transformation of the endometrium

Tolibova, Gulrukhsor Kh.; Хайбуллоевна, Толибова Гулрухсор; Tral, Tatyana G.; Георгиевна, Траль Татьяна; Ailamazyan, Eduard К.; Карпович, Айламазян Эдуард; Kogan, I.Yu.; Юрьевич, Коган Игорь

doi:10.17816/jowd6815-12

Cited by 6 publications

(1 citation statement)

References 39 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Именно средняя стадия фазы секреции характеризуется максимальной выработкой прогестерона желтым телом, и только на этой стадии эндометрий способен быть рецептивным за счет максимальной экспрессии и равномерного распределения PR в стромальном компартменте. В то же время в эпителии желез экспрессия PR уменьшается вплоть до нуле-вых значений или находится на низком уровне, а экспрессия ER в железах и строме эндометрия начинает повышаться, но распределение носит неравномерный характер [5].…”

Section: Introductionunclassified

Impaired Expression of Estrogen and Progesteron Receptors During the Implantation Window in Eutopic Endometrium of Infertile Women Associated with Endometriosis Genitalis Externa

Radzinsky¹,

Оразов²,

Mikhaleva³

et al. 2021

View full text Add to dashboard Cite

Study Objective: To study impaired expression of estrogen (ER) and progesteron (PR) receptor isoforms during the implantation window in eutopic endometrium of infertile women associated with endometriosis genitalis externa (EGE). Study Design: open perspective comparative study. Materials and Methods. The study included 32 patients with endometriosis-associated infertility and implantation failures within the scope of assisted reproductive technology programme (study group), and 33 fertile women with EGE rAFS (stages I to IV) (comparison group). We performed morphological and immunohistochemical examination of endometrium biopsy samples (pipelle biopsy) during an expected implantation window. Study Results. Eutopic endometrium of women with EGE and infertility during the implantation window demonstrated statistically higher (р < 0.05) expression of ERα (19-fold), ERβ (2.3-fold) in stroma and PR-B in glands (1.7-folds) as compared to fertile women win EGE with lower PR-A expression in stroma (2.5-fold). Conclusion. The morphofunctional condition of endometrium and its receptive properties during the implantation window in women with endometriosis-associated infertility reflect the nature of ER (α and β) and PR (А and В) isoforms expression, the abnormalities underlying the endometrium receptivity disorders, with clinical manifestations being absent pregnancy. Keywords: endometriosis-associated infertility; implantation window; endometrium receptivity

show abstract

Section: Introductionunclassified

Impaired Expression of Estrogen and Progesteron Receptors During the Implantation Window in Eutopic Endometrium of Infertile Women Associated with Endometriosis Genitalis Externa

Radzinsky¹,

Оразов²,

Mikhaleva³

et al. 2021

View full text Add to dashboard Cite

show abstract

Current status of endometrial dysfunction in the combined pathology of uterus: a literature review

Burova

Жаркин

Murzina

et al. 2021

V.F.Snegirev Archives of Obstetrics and Gynecology

View full text Add to dashboard Cite

Currently, the concern of endometrial dysfunction is still relevant and is of increasing interest. This is because of new factors have been identified that affect the reproductive function in women. Chronic endometritis and endometriosis mainly affect women of childbearing age, which threatens normal cyclic transformation of the endometrium and tissue receptivity. This consequently affects the main function of the endometrium, which is to ensure successful implantation of the fertilized egg and the development of the chorion and embryo. A detailed understanding of the functioning of the endometrium with a combination of chronic endometritis and endometriosis will improve their diagnosis and treatment.

show abstract

Modern aspects of the fascial structure of the pelvic floor (literature review)

Мусин

Yashchuk

Казихинуров

et al. 2021

V.F.Snegirev Archives of Obstetrics and Gynecology

View full text Add to dashboard Cite

The pelvic floor fascia in women has attracted the attention of obstetricians-gynecologists, proctologists and rehabilitologists due to their possible role in the development of pelvic organ prolapse and the appearance of pelvic pain. The development and improvement of new surgical techniques entails a comprehensive study of previously known approaches. For instance, regarding fascial tissues, studying the actual use of fascial flaps in plastic and reconstructive surgeries is of particular interest. This necessitates an accurate definition of and knowledge about structure of the fascia and their variations. In addition, knowledge of the fascial structure of surgical methods for treating prolapse, such as the installation of mesh prostheses in the reconstruction of the pelvic floor in the absence of alternative methods of correction. Primarily postoperative pain, a more in-depth study of the fascial anatomy of the pelvic floor can help reduce these adverse outcomes. The morphological and physiological characteristics of the perineal fascia presented in the teaching materials and teaching aids are not descriptive in nature and are far from the descriptive practice of obstetricians-gynecologists in the selection of methods for surgical correction of genital prolapse. This work is a literature review compiled from the sources of the electronic national bibliographic database of scientific citation of the Russian Science Citation Index and the English-language text database of medical and biological publications PubMed, created by the National Center for Biotechnological Information of the USA. To search for data, such key queries as fascia, pelvic floor, pelvic floor anatomy, genitourinary diaphragm, chronic pelvic pain were used, both individually and collectively.

show abstract

Molecular mechanisms of cyclic transformation of the endometrium

Cited by 6 publications

References 39 publications

Impaired Expression of Estrogen and Progesteron Receptors During the Implantation Window in Eutopic Endometrium of Infertile Women Associated with Endometriosis Genitalis Externa

Impaired Expression of Estrogen and Progesteron Receptors During the Implantation Window in Eutopic Endometrium of Infertile Women Associated with Endometriosis Genitalis Externa

Current status of endometrial dysfunction in the combined pathology of uterus: a literature review

Modern aspects of the fascial structure of the pelvic floor (literature review)

Contact Info

Product

Resources

About