Molecular mechanisms of curcumin and its analogs in colon cancer prevention and treatment

Selvam, Chelliah; Prabu, S.; Jordan, Brian C.; Purushothaman, Yasodha; Umamaheswari, A; Zare, Maryam Sadat Hosseini; Thilagavathi, Ramasamy

doi:10.1016/j.lfs.2019.117032

Cited by 84 publications

(40 citation statements)

References 109 publications

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“…In line with these data, we have to keep in mind that also plant hormones (such as abscisic acid, auxins and salicylates) and polyphenols (such as curcumin, lignans and cinnamic acid) can influence microbial richness, diversity and composition . Besides, abscisic acid, salicylates and curcumin exert positive effects against chronic and degenerative disease, including diabetes and cancer . Finally, answering the question of how food processing by the gut microbiota influences our immune system will give us the whole picture of this complex network.…”

Section: Dietmentioning

confidence: 85%

The mutual interplay of gut microbiota, diet and human disease

2020

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The intestinal milieu harbours the gut microbiota, consisting of a complex community of bacteria, archaea, fungi, viruses and protozoans that bring to the host organism an endowment of cells and genes more numerous than its own. In the last 10 years, mounting evidence has highlighted the prominent influence of the gut mutualistic bacterial communities on human health. Microbial colonization occurs alongside with immune system development and plays a role in intestinal physiology. The community of the gut microbiota does not undergo significant fluctuations throughout adult life. However, bacterial infections, antibiotic treatment, lifestyle, surgery and diet might profoundly affect it. Gut microbiota dysbiosis, defined as marked alterations in the amount and function of the intestinal microorganisms, is correlated with the aetiology of chronic noncommunicable diseases, ranging from cardiovascular, neurologic, respiratory and metabolic illnesses to cancer. In this review, we focus on the interplay among gut microbiota, diet and host to provide a perspective on the role of microbiota and their unique metabolites in the pathogenesis and/or progression of various human disorders. We discuss interventions based on microbiome studies, that is faecal microbiota transplantation, probiotics and prebiotics, to introduce the concept that correcting gut dysbiosis can ameliorate disease symptoms, thus offering a new approach towards disease treatment.

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Section: Dietmentioning

confidence: 85%

The mutual interplay of gut microbiota, diet and human disease

2020

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“…Curcumin, a strong antioxidant and anti-inflammatory agent, has been moved from kitchen to bench examining of its anticancer capacities in aspects of inhibition of cancer initiation, progression, and metastasis [21,31]. In addition to a panel of cancers [21,25,32,33], curcumin is also capable in inhibiting the growth of glioma and glioblastoma cells [34,35]. In literature, curcumin can induce GBM cells to die in forms of autophagy [36] and apoptosis [37].…”

Section: Discussionmentioning

confidence: 99%

Validation of Enhancing Effects of Curcumin on Radiotherapy with F98/FGT Glioblastoma-Bearing Rat Model

Wang

Shen

Chien

et al. 2020

IJMS

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Glioblastoma, the most common and aggressive brain tumor with low survival rate, is difficult to be cured by neurosurgery or radiotherapy. Mounting evidence has reported the anti-inflammatory and anticancer effects of curcumin on several types of cancer in preclinical studies and clinical trials. To our knowledge, there is no platform or system that could be used to effectively and real-timely evaluate the therapeutic efficacy of curcumin for glioblastoma multiforme (GBM). In this study, we constructed a lentivirus vector with triple-reporter genes (Fluc/GFP/tk) and transduced into rat F98 glioblastoma cells to establish an orthotopic F98/FGT glioma-bearing rat model. In the model, the therapeutic efficacies for curcumin alone, radiation alone, and their combination were evaluated via noninvasive bioluminescent imaging and overall survival measurements. At the cell level, curcumin is capable of causing a G2/M cell cycle arrest and sensitizing the F98 cells to radiation. In animal model, curcumin synergistically enhances the effects of radiotherapy on suppressing the growth of both transplanted glioma cells and in situ brain tumors, and extending the overall survival periods longer than those of curcumin alone and radiation alone treatments. In conclusion, we have demonstrated that curcumin may serve as a novel radiosensitizer to combine with radiotherapy using the triple-reporter F98/FGT animal model for effective and simultaneous evaluation of therapeutic efficacy.

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“…This substance has been reported to have exhibited anticancer effects in various malignant cells [87,111]. Curcumin and its analogs enhance the anticancer effects of conventional chemotherapeutic agents [112,113]. ROS production is one of the molecular mechanisms of curcumin-induced anticancer activity [114,115].…”

Section: Curcuminmentioning

confidence: 99%

Pathological and Pharmacological Roles of Mitochondrial Reactive Oxygen Species in Malignant Neoplasms: Therapies Involving Chemical Compounds, Natural Products, and Photosensitizers

et al. 2020

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Oxidative stress plays an important role in cellular processes. Consequently, oxidative stress also affects etiology, progression, and response to therapeutics in various pathological conditions including malignant tumors. Oxidative stress and associated outcomes are often brought about by excessive generation of reactive oxygen species (ROS). Accumulation of ROS occurs due to dysregulation of homeostasis in an otherwise strictly controlled physiological condition. In fact, intracellular ROS levels are closely associated with the pathological status and outcome of numerous diseases. Notably, mitochondria are recognized as the critical regulator and primary source of ROS. Damage to mitochondria increases mitochondrial ROS (mROS) production, which leads to an increased level of total intracellular ROS. However, intracellular ROS level may not always reflect mROS levels, as ROS is not only produced by mitochondria but also by other organelles such as endoplasmic reticulum and peroxisomes. Thus, an evaluation of mROS would help us to recognize the biological and pathological characteristics and predictive markers of malignant tumors and develop efficient treatment strategies. In this review, we describe the pathological significance of mROS in malignant neoplasms. In particular, we show the association of mROS-related signaling in the molecular mechanisms of chemically synthesized and natural chemotherapeutic agents and photodynamic therapy.

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Molecular mechanisms of curcumin and its analogs in colon cancer prevention and treatment

Cited by 84 publications

References 109 publications

The mutual interplay of gut microbiota, diet and human disease

The mutual interplay of gut microbiota, diet and human disease

Validation of Enhancing Effects of Curcumin on Radiotherapy with F98/FGT Glioblastoma-Bearing Rat Model

Pathological and Pharmacological Roles of Mitochondrial Reactive Oxygen Species in Malignant Neoplasms: Therapies Involving Chemical Compounds, Natural Products, and Photosensitizers

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