Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances

Surh, Young‐Joon

doi:10.1016/s1383-5742(99)00057-5

Cited by 543 publications

(318 citation statements)

References 189 publications

Supporting

Mentioning

312

Contrasting

Unclassified

Order By: Relevance

“…A good chemopreventive agent is a naturally occurring agent that can induce apoptosis in cancer cell without much side effects (Surh, 1999). Chlorella vulgaris (CV) is a unicellular green microalgae that has been widely used for centuries as a food source with complete nutrients, such as carbohydrate, protein, vitamins and minerals, and is marketed commercially as health supplement or incorporated in food such as cereals (Haperin et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Chlorella vulgaris triggers apoptosis in hepatocarcinogenesis-induced rats

Azamai

Sulaiman

Habib

et al. 2009

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Chlorella vulgaris (CV) has been reported to have antioxidant and anticancer properties. We evaluated the effect of CV on apoptotic regulator protein expression in liver cancer-induced rats. Male Wistar rats (200~250 g) were divided into eight groups: control group (normal diet), CDE group (choline deficient diet supplemented with ethionine in drinking water to induce hepatocarcinogenesis), CV groups with three different doses of CV (50, 150, and 300 mg/kg body weight), and CDE groups treated with different doses of CV (50, 150, and 300 mg/kg body weight). Rats were sacrificed at various weeks and liver tissues were embedded in paraffin blocks for immunohistochemistry studies. CV, at increasing doses, decreased the expression of anti-apoptotic protein, Bcl-2, but increased the expression of pro-apoptotic protein, caspase 8, in CDE rats, which was correlated with decreased hepatoctyes proliferation and increased apoptosis as determined by bromodeoxy-uridine (BrdU) labeling and terminal deoxynucleotidyl transferase mediated dUTP nick-end labeling (TUNEL) assay, respectively. Our study shows that CV has definite chemopreventive effect by inducing apoptosis via decreasing the expression of Bcl-2 and increasing the expression of caspase 8 in hepatocarcinogenesis-induced rats.

show abstract

Section: Introductionmentioning

confidence: 99%

Chlorella vulgaris triggers apoptosis in hepatocarcinogenesis-induced rats

Azamai

Sulaiman

Habib

et al. 2009

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

show abstract

“…The fraction of EF not only exhibited excellent antioxidant activity but also possessed a potent effect on inhibiting cancer cell growth, suggesting that the active phenolic components serving as the natural antioxidants in EF including yakuchinone A and yakuchinone B, which have been reported to possess antiproliferative activity on mouse skin tumor and HL-60 cells (Surh, 1999), might be also responsible for the chemoprotective effects against cancer cells. PF showed significant anticancer capacity but relatively weak antioxidant activity, indicating that the main active compounds serving as anticancer agents in PF may not belong to polyphenols and deserve further study.…”

Section: Cytotoxic Activitymentioning

confidence: 99%

In vitroantioxidant and cytotoxic properties of ethanol extract ofAlpinia oxyphyllafruits

Wang

Yuan

Bao

et al. 2013

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Alpinia oxyphylla Miquel (Zingiberaceae) is a traditional Chinese herbal medicine widely used for the treatment of intestinal disorders, urosis and diuresis. However, information about antioxidant and cytotoxic properties of its fruits remains to be elucidated. Objective: The ethanol crude extract (CE) and its fractions [petroleum ether fraction (PF), ethyl acetate fraction (EF), n-butanol fraction (BF) and water fraction (WF) extracted by petroleum ether, ethyl acetate, n-butanol and water, respectively] of A. oxyphylla fruits were investigated for their antioxidant activity and cytotoxicity. Materials and methods: The total phenolic content (TPC) and antioxidant activity of the extracts were determined by Folin-Ciocalteu reagent, 1,1-diphenyl-2-picrylhydrazyl (DPPH . ), Trolox equivalent antioxidant capacity and reducing power assay. Cytotoxicity of the extracts (0-200 mg/mL) was tested on six human cancer cell lines (breast cancer cell line, cervix carcinoma cell line, lung adenocarcinoma cell line, liver carcinoma cell line, gastric cancer cell line and colon cancer cell line) using the sulforhodamine B assay. Results: The TPC of extracts varied from 8.2 to 20.3 mg gallic acid equivalents/g dry weight. DPPH radical scavenging effect of extracts decreased in the order of EF4BF4CE4PF4WF, with IC 50 values ranging from 74.7 to 680.8 mg/mL. 2,2-azo-bis(3-Ethylbenzothiazoline-6-sulfoic acid) diammonium salt scavenging activity ranged from 0.118 to 0.236 mmol Trolox equivalence/mg extract. The extracts exhibited concentration-dependent reducing power, and EF showed the highest reducing ability. A satisfactory correlation (R 2 40.826) between TPC and antioxidant activity was observed. In addition, EF, PF and CE exhibited potent anticancer effects on six cancer cell lines with IC 50 values ranging from 40

show abstract

“…In the past several decades, nonnutrient phytochemicals found in fruits and vegetables have been examined, and a number of promising natural product leads have resulted from this research effort (15,17,18). For example, green tea extract and pure compounds such as caffeic acid phenethyl ester, capsaicin, curcumin, 6-gingerol, indole-3-carbinol, lycopene, and perillyl alcohol are undergoing clinical trials for their cancer chemopreventive activities (15,19,20).…”

Section: Overview Of Cancer Chemoprevention Trials Involving Phytochementioning

confidence: 99%

Resveratrol as an Inhibitor of Carcinogenesis

Pezzuto

2008

Pharmaceutical Biology

View full text Add to dashboard Cite

Given the high probability of developing cancer over the period of a normal life span, cancer chemoprevention provides an attractive therapeutic strategy for the delay or reversal of this process. A variety of phytochemicals, such as sulfides, isothiocyanates, glucosinolates, flavonoids, carotenoids, phenols, and diarylhepanoids, are known to mediate chemopreventive responses. Resveratrol, a ubiquitous stilbene found in the diet of human beings (e.g., as a component of grapes and wine), was uncovered by bioassay-guided fractionation and found to mediate cancer chemopreventive activity in a murine model with mechanisms involving various stages of the carcinogenic process. This work spurred a myriad of studies that are summarized in this article. As demonstrated with in vitro and cell culture models, resveratrol functions through a plethora of mechanisms, which can vary from model to model. Results from differential gene expression studies are daunting. Irrespective of the precise mechanism, however, efficacy has been demonstrated in some animal models, and a critical evaluation of resveratrol data relative to the characteristics of a promising cancer chemopreventive agent leads to favorable consideration. Animal studies have shown cancer inhibitory activity in a number of models, including adenoma, skin, breast, colon, esophagus, glioma, intestinal, liver, and neuroblastoma. Biomarkers are known, and ample quantities of compound can be produced. Dietary administration is feasible. Several small-scale human trials are under way, and human intervention trials may follow. As learned by past experience, data from these trials are necessary prior to drawing any conclusions, but the current cancer chemopreventive profile of resveratrol provides promise for widespread use in the future. Accepted: April 7, 2008. 1 This review has been revised, expanded, and updated from a previous chapter (see. Ref. 1) on the same subject.2 Due to the unique nature of this review, the format is atypical. The references are presented by number, rather than by author name and year, and the tables are presented at the end of the text, as they are so extensive.

show abstract

Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances

Cited by 543 publications

References 189 publications

Chlorella vulgaris triggers apoptosis in hepatocarcinogenesis-induced rats

Chlorella vulgaris triggers apoptosis in hepatocarcinogenesis-induced rats

In vitroantioxidant and cytotoxic properties of ethanol extract ofAlpinia oxyphyllafruits

Resveratrol as an Inhibitor of Carcinogenesis

Contact Info

Product

Resources

About