Molecular mechanism of binding of pyrrolo(1,4)benzodiazepine antitumour agents to deoxyribonucleic acid—

Electrochemical Analysis of Anthramycin: Hydrolysis, DNA-Interactions and Quantitative Determination

“…Another common feature in anthramycin studies is the use of phosphate buffers [9] at neutral pH. In electrochemical studies of DNA and its interactions, AFP (0.3 M ammonium formate plus 50 mM phosphate buffer solution, pH 6.9) is the usual electrolyte [14,15] and it could be appropriate to employ it in this study, since it contains phosphate buffer and has a neutral pH.…”

Mechanism of action of dnacin B1, a new benzoquinoid antibiotic with antitumor properties

“…The initial neotetrazolium reduction rate was measured at 500 nm and 25°C. SOD was added at a concentration of 5 (5,6,12,13,20), this moiety in dnacin B1 might also be involved in its preferential binding to guanine residues in DNA. In thermal denaturation studies, dnacin B1-treated DNA with a high G+C content ( Fig.…”

Pyrrolobenzodiazepines as Sequence Selective DNA Binding Agents

“…[25] Extensive reviews of the synthetic literature of the PBDs have appeared in 1994, 1998 and 2002. [26] Various approaches to the synthesis of PBD antibiotics have been investigated, including hydride reduction of seven-membered cyclic dilactams, [27] reductive cyclization of acyclic nitroaldehydes, [28] iminothioether approach [29] cyclization of aminothioacetals, [30] deprotective cyclization of the diethylthioacetals via N10 protected precursors, [31] oxidation of cyclic secondary amines, [32] reductive cyclizations [33] and solid phase approaches. [34] Various synthetic methods for the synthesis of the PBDs have been reviewed extensively.…”