Electrochemical Analysis of Anthramycin: Hydrolysis, DNA-Interactions and Quantitative Determination

Teijeiro, C.; Red, E. de la; Marín, Dolores Pérez

doi:10.1002/1521-4109(200008)12:12<963::aid-elan963>3.0.co;2-b

Cited by 29 publications

(14 citation statements)

References 17 publications

(19 reference statements)

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“…Teijeiro et al [34] studied DNA-interactions and quantitative analysis of antineoplastic antibiotic, anthramycin, which is similar to other antibiotics, like MC and Ecteinascidin 743, by using differential pulse polarography in aqueous buffered media at HMDE. It was reported that anthramycin produced covalent adducts with native DNA.…”

Section: The Quantification Of Drug And/or Dna Monitoringmentioning

confidence: 99%

Electrochemical DNA Biosensors Based on DNA-Drug Interactions

Erdem¹,

Ozsoz²

2002

Electroanalysis

244

130

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Section: The Quantification Of Drug And/or Dna Monitoringmentioning

confidence: 99%

Electrochemical DNA Biosensors Based on DNA-Drug Interactions

Erdem¹,

Ozsoz²

2002

Electroanalysis

244

130

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“…Electrochemical methods [19][20][21][22][23][24][25][26][27][28] such as differential pulse polarography (DPP) and cyclic voltammetry (CV) have been widely applied for the determination of pharmaceuticals. In general these methods offer high sensitivity, low limit of detection, easy operation and the use of simple instrumentation.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric behavior of cefdinir in solubilized system

Jain

Dwivedi

Mishra

2008

Journal of Colloid and Interface Science

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“…8 The quantification of drugs or drug monitoring based on DNA-drug interactions has been reported. [9][10][11][12] DNA is usually chosen as a surface-modification element because of its high sensitivity, and compatibility with modern micro-fabrication technologies; it is especially promising for rapid detection. 13,14 Measurements of some trace phenothiazine drugs were performed with a DNA-modified carbon paste electrode (CPE) by using a potentiometric stripping analysis (PSA) method.…”

mentioning

confidence: 99%

Electrochemical Determination of Trace Promethazine Hydrochloride by a Pretreated Glassy Carbon Electrode Modified with DNA

et al. 2007

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Phenothiazines are a group of basic drugs that include a phenothiazine ring with different substituents attached at the 2-and 10-position, which are used as anti-psychotics, neuroleptics and antihistamines. 1 Several methods have been applied to detect phenothiazine derivatives, such as spectrophotometry, 2 colorimetry, 3 liquid chromatography (LC) 4 and titrimetry. 5 Promethazine hydrochloride, a prominent compound in the large group of phenothiazine derivatives, is widely used as a therapeutic agent for treating various mental and personality disorder. Daniela et al. 6 have reported the determination of promethazine hydrochloride in a pharmaceutical preparation using a flow-injection spectroelectroanalytical method. Lara et al. 7 utilized a capillary zone electrophoresis (CZE) technique for the quantitative analysis of three kinds of phenothiazines. The detection limit for promethazine hydrochloride was obtained to be 3.3 μg/mL; DPV and DC techniques were also applied to detect some phenothiazine drugs. 8 The quantification of drugs or drug monitoring based on DNA-drug interactions has been reported. [9][10][11][12] DNA is usually chosen as a surface-modification element because of its high sensitivity, and compatibility with modern micro-fabrication technologies; it is especially promising for rapid detection. 13,14 Measurements of some trace phenothiazine drugs were performed with a DNA-modified carbon paste electrode (CPE) by using a potentiometric stripping analysis (PSA) method. DNA-modified CPE permits measurements at low concentration levels of some phenothiazines with an accumulation step. 15 These previous studies suggested that a DNA-modified electrode might provide a very promising basis for determining trace promethazine.In the present work, DNA-modified electrode was assembled by immobilizing dsDNA onto the surface of a pretreated glassy carbon electrode (GCE(ox)). A pair of well-defined reversible redox peaks of promethazine was observed at low potential on the DNA/GCE(ox). The redox peak current was evaluated by using CV and DPV techniques. The signal was about 100-fold higher on DNA/GCE(ox) than that obtained on the DNA/GCE. By means of the redox peak currents of promethazine sensitively responding to the promethazine concentration, DNA/GCE(ox) could be applied to determine trace promethazine. The influence of a glassy carbon electrode pretreatment on the sensitivity of determining promethazine was considered. DNA/GCE(ox) was used to determine promethazine in healthy human serum with satisfactory results. Experimental Apparatus and reagentsElectrochemical measurements were performed with a CHI660A electrochemical analyzer (Shanghai Chenhua Apparatus Corporation, China). Glassy carbon electrodes (diameter 3 mm) and DNA modified glassy carbon electrodes were used as the working electrode, respectively. A platinum auxiliary electrode and an Ag/AgCl reference electrode were used for the measurements.Calf thymus (CT) DNA (Cat. No. D1501) and promethazine hydrochloride (Cat. No. P4651) were purchase...

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Electrochemical Analysis of Anthramycin: Hydrolysis, DNA-Interactions and Quantitative Determination

Cited by 29 publications

References 17 publications

Electrochemical DNA Biosensors Based on DNA-Drug Interactions

Electrochemical DNA Biosensors Based on DNA-Drug Interactions

Voltammetric behavior of cefdinir in solubilized system

Electrochemical Determination of Trace Promethazine Hydrochloride by a Pretreated Glassy Carbon Electrode Modified with DNA

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