Molecular Mechanism Exploration of Pancreatitis Based on miRNA Expression Profile

Wen, Caiyun; Sun, Houchang; Pan, Ke‐Hua; Sun, Hui; Zhang, Zhao; Cao, Guoquan; Wang, Meihao

doi:10.7754/clin.lab.2018.180807

Cited by 12 publications

(9 citation statements)

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“…This has a certain clinical guiding significance for patients with LUAD after platinum resistance. Has-miR-374a-5p is related to the occurrence and development of pancreatitis ( Wen et al, 2019 ), but the relationship between has-miR-374a-5p and platinum drug resistance of LUAD has not been explored. ceRNA analysis showed that has-miR-374a-5p is highly expressed in healthy individuals, and the higher the expression, the better the survival.…”

Section: Discussionmentioning

confidence: 99%

Expression patterns of platinum resistance-related genes in lung adenocarcinoma and related clinical value models

Wang

et al. 2022

Front. Genet.

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The purpose of this study was to explore platinum resistance-related biomarkers and mechanisms in lung adenocarcinoma. Through the analysis of gene expression data of lung adenocarcinoma patients and normal patients from The Cancer Genome Atlas, Gene Expression Omnibus database, and A database of genes related to platinum resistance, platinum resistance genes in lung adenocarcinoma and platinum resistance-related differentially expressed genes were obtained. After screening by a statistical significance threshold, a total of 252 genes were defined as platinum resistance genes with significant differential expression, of which 161 were up-regulated and 91 were down-regulated. The enrichment results of up-regulated gene Gene Ontology (GO) showed that TOP3 entries related to biological processes (BP) were double-strand break repair, DNA recombination, DNA replication, the down-regulated gene GO enriches the TOP3 items about biological processes (BP) as a response to lipopolysaccharide, muscle cell proliferation, response to molecule of bacterial origin. Gene Set Enrichment Analysis showed that the top three were e2f targets, g2m checkpoint, and rgf beta signaling. A prognostic model based on non-negative matrix factorization classification showed the characteristics of high- and low-risk groups. The prognostic model established by least absolute shrinkage and selection operator regression and risk factor analysis showed that genes such as HOXB7, NT5E, and KRT18 were positively correlated with risk score. By analyzing the differences in m6A regulatory factors between high- and low-risk groups, it was found that FTO, GPM6A, METTL3, and YTHDC2 were higher in the low-risk group, while HNRNPA2B1, HNRNPC, TGF2BP1, IGF2BP2, IGF2BP3, and RBM15B were higher in the high-risk group. Immune infiltration and drug sensitivity analysis also showed the gene characteristics of the platinum-resistant population in lung adenocarcinoma. ceRNA analysis showed that has-miR-374a-5p and RP6-24A23.7 were lower in the tumor expression group, and that the survival of the low expression group was worse than that of the high expression group. In conclusion, the results of this study show that platinum resistance-related differentially expressed genes in lung adenocarcinoma are mainly concentrated in biological processes such as DNA recombination and response to lipopolysaccharide. The validation set proved that the high-risk group of our prognostic model had poor survival. M6A regulatory factor analysis, immune infiltration, and drug sensitivity analysis all showed differences between high and low-risk groups. ceRNA analysis showed that has-miR-374a-5p and RP6-24A23.7 could be protective factors. Further exploration of the potential impact of these genes on the risk and prognosis of drug-resistant patients with lung adenocarcinoma would provide theoretical support for future research.

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Section: Discussionmentioning

confidence: 99%

Expression patterns of platinum resistance-related genes in lung adenocarcinoma and related clinical value models

Wang

et al. 2022

Front. Genet.

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“…Promising tools, such as nCLE, are currently being developed and require more studies for the verification of their diagnostic efficiency and potential. Furthermore, probable biomarkers for the diagnosis of early CP or to rule out malignancy, such as metabolomic and microRNA signatures in the blood, have been investigated, but they also require further verification[ 97 - 100 ].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive review of diagnostic modalities for early chronic pancreatitis

Ge¹,

Dietrich²,

Bhutani³

et al. 2021

WJG

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Chronic pancreatitis (CP) is a progressive condition caused by several factors and characterised by pancreatic fibrosis and dysfunction. However, CP is difficult to diagnose at an early stage. Various advanced methods including endoscopic ultrasound based elastography and confocal laser endomicroscopy have been used to diagnose early CP, although no unified diagnostic standards have been established. In the past, the diagnosis was mainly based on imaging, and no comprehensive evaluations were performed. This review describes and compares the advantages and limitations of the traditional and latest diagnostic modalities and suggests guidelines for the standardisation of the methods used to diagnose early CP.

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“…Recent studies have demonstrated aberrant microRNAs (miRs) expression patterns in pancreatic tissues obtained from patients experiencing acute, chronic pancreatitis, or pancreatic cancer compared to tissues from unaffected individuals [ 23 , 24 ]. MiRs are a class of noncoding RNAs with 18–24 nucleotides in length that play a crucial role in regulating gene expression [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of MicroRNAs in Pancreatitis Development and Progression

Patel

Almanzar

LaComb

et al. 2023

IJMS

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Pancreatitis (acute and chronic) is an inflammatory disease associated with significant morbidity, including a high rate of hospitalization and mortality. MicroRNAs (miRs) are essential post-transcriptional modulators of gene expression. They are crucial in many diseases’ development and progression. Recent studies have demonstrated aberrant miRs expression patterns in pancreatic tissues obtained from patients experiencing acute and chronic pancreatitis compared to tissues from unaffected individuals. Increasing evidence showed that miRs regulate multiple aspects of pancreatic acinar biology, such as autophagy, mitophagy, and migration, impact local and systemic inflammation and, thus, are involved in the disease development and progression. Notably, multiple miRs act on pancreatic acinar cells and regulate the transduction of signals between pancreatic acinar cells, pancreatic stellate cells, and immune cells, and provide a complex interaction network between these cells. Importantly, recent studies from various animal models and patients’ data combined with advanced detection techniques support their importance in diagnosing and treating pancreatitis. In this review, we plan to provide an up-to-date summary of the role of miRs in the development and progression of pancreatitis.

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Molecular Mechanism Exploration of Pancreatitis Based on miRNA Expression Profile

Cited by 12 publications

References 0 publications

Expression patterns of platinum resistance-related genes in lung adenocarcinoma and related clinical value models

Expression patterns of platinum resistance-related genes in lung adenocarcinoma and related clinical value models

Comprehensive review of diagnostic modalities for early chronic pancreatitis

The Role of MicroRNAs in Pancreatitis Development and Progression

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