Molecular mechanism and therapeutic significance of dihydromyricetin in nonalcoholic fatty liver disease

Gong, Hui; Xu, Huimei; Li, Muyang; Zhang, Dekui

doi:10.1016/j.ejphar.2022.175325

Cited by 3 publications

(1 citation statement)

References 61 publications

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“…Dihydromyricetin (DHM), called ampelopsin, is the main dihydroflavonol flavonoid compound in vine tea and widely exists in Garcinia, Vitis, and Myricaceae plants [1]. It has a variety of biological functions, including scavenging free radicals, antioxidation, antitumor, anti-inflammatory, inhibiting hepatocyte deterioration, accelerating liver cell proliferation, and reducing liver injury [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activities of Dihydromyricetin Derivatives with Different Acyl Donor Chain Lengths Synthetized by Lipozyme TL IM

Wang

Zhu

et al. 2023

Foods

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Dihydromyricetin (DHM) is a phytochemical with multiple bioactivities. However, its poor liposolubility limits its application in the field. In this study, DHM was acylated with different fatty acid vinyl esters to improve its lipophilicity, and five DHM acylated derivatives with different carbon chain lengths (C2-DHM, C4-DHM, C6-DHM, C8-DHM, and C12-DHM) and different lipophilicity were synthesized. The relationship between the lipophilicity and antioxidant activities of DHM and its derivatives was evaluated with oil and emulsion models using chemical and cellular antioxidant activity (CAA) tests. The capacity of DHM derivatives to scavenge 1,1-diphenyl-2-picrylhydrazyl radical (DPPH•) and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical (ABTS+•) was similar to that of DHM, except for C12-DHM. The antioxidant activity of DHM derivatives was lower than that of DHM in sunflower oil, while C4-DHM exhibited better antioxidant capacity in oil-in-water emulsion. In CAA tests, C8-DHM (median effective dose (EC50) 35.14 μmol/L) exhibited better antioxidant activity than that of DHM (EC50: 226.26 μmol/L). The results showed that in different antioxidant models, DHM derivatives with different lipophilicity had various antioxidant activities, which has guiding significance for the use of DHM and its derivatives.

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Section: Introductionmentioning

confidence: 99%

Antioxidant Activities of Dihydromyricetin Derivatives with Different Acyl Donor Chain Lengths Synthetized by Lipozyme TL IM

Wang

Zhu

et al. 2023

Foods

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Chickpea (Cicer arietinum) protein hydrolysate ameliorates metabolic effects of feeding a high-fat diet to mice

Radlowski,

Castañeda-Reyes,

Gonzalezde Mejia

2024

Journal of Functional Foods

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Dihydromyricetin functions as a tumor suppressor in hepatoblastoma by regulating SOD1/ROS pathway

et al. 2023

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BackgroundHepatoblastoma has an unsatisfactory prognosis, and traditional chemotherapy has strong side effects. Dihydromyricetin is a flavonoid extracted from a woody vine of the genus Serpentine in the family Vitaceae, with effects such as preventing alcoholic liver and reducing the incidence of liver cancer. However, the effect of DHM on hepatoblastoma and its specific pathway are still unclear.PurposeThe purpose of this study was to investigate the effects of DHM on children's hepatoblastoma and its related mechanisms.MethodsCCK-8 assays were used to measure proliferation. Apoptosis and reactive oxygen species (ROS) were analyzed by flow cytometry. Apoptotic cells were observed using Hoechst 33342 staining and fluorescence microscopy. Protein expression levels in HuH-6 and HepG2 cells were determined by western blotting.ResultsWe found that DHM was able to inhibit the growth and increase cellular mortality in HuH-6 and HepG2 cells. Furthermore, DHM decreased the intracellular ROS level and increased the expression of SOD1. ROS scavenger NAC promoted apoptosis, while the use of SOD1 inhibitor LCS-1 weakened the ROS scavenging effect of DHM , and to some extent reduced the killing effect of DHM on hepatoblastoma cells.ConclusionThese results suggest that regulating SOD1/ROS pathway to induce apoptosis is one of the potential mechanisms of DHM as a tumor suppressor in hepatoblastoma. Therefore, DHM may be a novel candidate for inhibiting hepatoblastoma growth and deserves further study.

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Molecular mechanism and therapeutic significance of dihydromyricetin in nonalcoholic fatty liver disease

Cited by 3 publications

References 61 publications

Antioxidant Activities of Dihydromyricetin Derivatives with Different Acyl Donor Chain Lengths Synthetized by Lipozyme TL IM

Antioxidant Activities of Dihydromyricetin Derivatives with Different Acyl Donor Chain Lengths Synthetized by Lipozyme TL IM

Chickpea (Cicer arietinum) protein hydrolysate ameliorates metabolic effects of feeding a high-fat diet to mice

Dihydromyricetin functions as a tumor suppressor in hepatoblastoma by regulating SOD1/ROS pathway

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