Molecular Interactions in Organic Nanoparticles for Phototheranostic Applications

Ng, Kenrick; Zheng, Gang

doi:10.1021/acs.chemrev.5b00140

Cited by 494 publications

(389 citation statements)

References 205 publications

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“…[3] Delayed fluorescence can also occur when two excited states interact and annihilate forming an emitting state, e.g., in triplet-triplet annihilation. [4,5] Triplet-triplet annihilation is an encouraging up-conversion approach due to its low excitation power density, high quantum yield, tunable excitation/emission wavelength and strong absorption. r Phosphorescence; emission of a photon from T 1 to the vibrational sates of S 0 .…”

Section: Non-radiative Processesmentioning

confidence: 99%

Optical Properties of Hybrid Organic‐Inorganic Materials and their Applications

Parola

Julián‐López

Carlos

et al. 2016

Adv Funct Materials

244

116

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Research on hybrid inorganic‐organic materials has experienced an explosive growth since the 1980s, with the expansion of soft inorganic chemistry based processes. Indeed, mild synthetic conditions, low processing temperatures provided by “chimie douce” and the versatility of the colloidal state allow for the mixing of the organic and inorganic components at the nanometer scale in virtually any ratio to produce the so called hybrid materials. Today a high degree of control over both composition and nanostructure of these hybrids can be achieved allowing tunable structure‐property relationships. This, in turn, makes it possible to tailor and fine‐tune many properties (mechanical, optical, electronic, thermal, chemical…) in very broad ranges, and to design specific multifunctional systems for applications. In particular, the field of “Hybrid‐Optics” has been very productive not only scientifically but also in terms of applications. Indeed, numerous optical devices based on hybrids are already in, or very close, to the market. This review describes most of the recent advances performed in this field. Emphasis will be given to luminescent, photochromic, NLO and plasmonic properties. As an outlook we show that the controlled coupling between plasmonics and luminescence is opening a land of opportunities in the field of “Hybrid‐Optics”.

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Section: Non-radiative Processesmentioning

confidence: 99%

Optical Properties of Hybrid Organic‐Inorganic Materials and their Applications

Parola

Julián‐López

Carlos

et al. 2016

Adv Funct Materials

244

116

View full text Add to dashboard Cite

show abstract

“…PDT can trigger drug release from NPs or endocytic vesicles by inducing reactive oxygen species (ROS) generation and destabilizing the cytoplasmic membrane [66][67][68][69] . For example, Lin et al employed nanoscale coordination polymers (NCPs) to construct a PS-loaded hybrid NP.…”

Section: Wwwchinapharcom Liu Jp Et Almentioning

confidence: 99%

Smart nanoparticles improve therapy for drug-resistant tumors by overcoming pathophysiological barriers

Liu

Wang

et al. 2016

Acta Pharmacol Sin

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The therapeutic outcome of chemotherapy is severely limited by intrinsic or acquired drug resistance, the most common causes of chemotherapy failure. In the past few decades, advancements in nanotechnology have provided alternative strategies for combating tumor drug resistance. Drug-loaded nanoparticles (NPs) have several advantages over the free drug forms, including reduced cytotoxicity, prolonged circulation in the blood and increased accumulation in tumors. Currently, however, nanoparticulate drugs have only marginally improved the overall survival rate in clinical trials because of the various pathophysiological barriers that exist in the tumor microenvironment, such as intratumoral distribution, penetration and intracellular trafficking, etc. Smart NPs with stimulusadaptable physico-chemical properties have been extensively developed to improve the therapeutic efficacy of nanomedicine. In this review, we summarize the recent advances of employing smart NPs to treat the drug-resistant tumors by overcoming the pathophysiological barriers in the tumor microenvironment.

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“…Fluorescence spectra showed that incorporation of ICG in the nanoparticulate formulation resulted in a significant suppression of fluorescence emission (74%) ( figure 4(b)). This phenomenon can be attributed to the nanoparticulate structure, which offers a different local environment to the bound ICG molecule when compared with the free form [33]. ICG molecules that are in close proximity within the nanoparticle assembly quench each another and this inevitably results in reduced fluorescence emission [34,35].…”

Section: Nanoparticle Characterization and The Effect Of Digestion Wimentioning

confidence: 99%

Cathepsin B-degradable, NIR-responsive nanoparticulate platform for target-specific cancer therapy

et al. 2016

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Stimuli-responsive anticancer formulations can promote drug release and activation within the target tumour, facilitate cellular uptake, as well as improve the therapeutic efficacy of drugs and reduce off-target effects. In the present work, indocyanine green (ICG)-containing polyglutamate (PGA) nanoparticles were developed and characterized. Digestion of nanoparticles with cathepsin B, a matrix metalloproteinase overexpressed in the microenvironment of advanced tumours, decreased particle size and increased ICG cellular uptake. Incorporation of ICG in PGA nanoparticles provided the NIR-absorbing agent with time-dependent altered optical properties in the presence of cathepsin B. Having minimal dark toxicity, the formulation exhibited significant cytotoxicity upon NIR exposure. Combined use of the formulation with saporin, a ribosome-inactivating protein, resulted in synergistically enhanced cytotoxicity attributed to the photo-induced release of saporin from endo/lysosomes. The results suggest that this therapeutic approach can offer significant therapeutic benefit in the treatment of superficial malignancies, such as head and neck tumours.

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Molecular Interactions in Organic Nanoparticles for Phototheranostic Applications

Cited by 494 publications

References 205 publications

Optical Properties of Hybrid Organic‐Inorganic Materials and their Applications

Optical Properties of Hybrid Organic‐Inorganic Materials and their Applications

Smart nanoparticles improve therapy for drug-resistant tumors by overcoming pathophysiological barriers

Cathepsin B-degradable, NIR-responsive nanoparticulate platform for target-specific cancer therapy

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