Molecular interactions between zoledronic acid and bone: An in vitro Raman microspectroscopic study

Juillard, A.; Falgayrac, Guillaume; Cortet, Bernard; Vieillard, Marie-Hélène; Azaroual, Nathalie; Hornez, Jean‐Christophe; Penel, Guillaume

doi:10.1016/j.bone.2010.07.018

Cited by 38 publications

(13 citation statements)

References 44 publications

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“… On the other hand, a first principles study of the vibrational features of hydroxylapatite and type A carbonated apatite was performed by Ulian et al , and Raman spectroscopy was employed to investigate the interactions of bovine bone, HAP, and calcium hydrogen phosphate with the HEDP bisphosphonate, being shown the feasibility of using Raman spectroscopy to distinguish between different complexes formed at the solid/solution interface. Juillard et al studied the molecular interactions between zoledronic acid and bone tissue by using Raman microspectroscopy, finding new and useful information on the impact of zoledronic acid on bone composition at the molecular level to understand how bisphosphonates improve bone strength. Iafisco et al , by the way, have carried out surface‐enhanced Raman spectroscopy to assess the adsorption of myoglobine on HAP nanocrystals functionalized with alendronate, revealing that the covering of nano‐HAP crystals by alendronate inhibits the adsorption of myoglobin.…”

Section: Discussionmentioning

confidence: 99%

Phosphate group vibrational signatures of the osteoporosis drug alendronate

Neto

Lima‐Neto

Sales

et al. 2014

J Raman Spectroscopy

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The infrared (IR) and Raman spectra of the osteoporosis drug alendronate in the monosodium trihydrate alendronate crystal were measured. In order to interpret them, density functional theory (DFT) calculations for the solvated alendronate molecule were performed following the structural features revealed by X‐ray data. A comparison between the DFT‐calculated IR and Raman of the converged species and the measured spectra unveils relevant phosphate group signatures in the 400–1400 cm−1 wavenumber range, especially IR absorption bands at 1015, 1049, 1067, 1131, 1177, and 1235 cm−1, which were related to CP and OP bond length stretching, and Raman lines at 449, 661, and 969 cm−1, involving phosphate scissors and bond length vibrations. A comparison with experimental data of alendronate incorporated into hydroxyapatite (HAP) indicates that, for wavenumbers below 1500 cm−1, the interaction of alendronate with HAP does not affect significantly the alendronate vibrational spectra, while for the 1600–3000 cm−1 interval the interaction with HAP changes the normal mode wavenumbers by about −100 cm−1. Copyright © 2014 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Phosphate group vibrational signatures of the osteoporosis drug alendronate

Neto

Lima‐Neto

Sales

et al. 2014

J Raman Spectroscopy

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“…Several studies illustrate that the fixation of BP is accompanied by the release of some elements from the adsorbent surface such as the liberation of silicon and phosphorus. As reported by several authors [34,35] for other BP, it can be postulated that risedronate species participate in an ionic exchange process with active mineral ions on the surfaces of bioactive glass, particularly silicon, which share the same ionic sites at the surface. Silicon intervenes in several physicochemical properties after its immersion in the SBF solution or after its in vivo experiment.…”

Section: Analysis Of the Solutions After Uptake Of Risedronates (Solumentioning

confidence: 67%

Risedronate adsorption on bioactive glass surface for applications as bone biomaterial

Mosbahi

Oudadesse

Lefeuvre

et al. 2016

Applied Surface Science

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International audienceThe aim of the current work is to study the physicochemical interactions between bisphosphonates molecules, risedronate (RIS) and bioactive glass (46S6) after their association by adsorption phenomenon. To more understand the interaction processes of RIS with the 46S6 surface we have used complementary physicochemical techniques such as Infrared (FTIR), RAMAN and nuclear magnetic resonance (NMR) spectroscopy. The obtained results suggest that risedronate adsorption corresponds to an ion substitution reaction with silicon ions occurring at the bioactive glass surface. Thus, a pure bioactive glass was synthesized and fully characterized comparing the solids after adsorption (46S6-XRIS obtained after the interaction of 46S6 and X% risedronate). Therefore, based on the spectroscopic results FTIR, RMAN and MAS-NMR, it can be concluded that strong interactions have been established between RIS ions and 46S6 surface. In fact, FTIR and RAMAN spectroscopy illustrate the fixation of risedronate on the bioactive glass surface by the appearance of several bands characterizing risedrontre. The 31P MAS-NMR of the composite 46S6-XRIS show the presence of two species at a chemical shift of 15 and 19 ppm demonstrating thus the fixation of the RIS on 46S6 surface

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“…Our group concluded that the combination of FT-IR and NIR spectroscopy was more powerful than FT-IR, NIR or Raman spectroscopy alone to discriminate genuine from illegal Viagra ® samples [8]. X-ray powder diffraction [9], NMR ( 1 H, 13 C, 15 N) [10], and NMR (2D DOSY, 3D DOSY-COSY, 1 H NMR) [11] were also used to detect counterfeit Viagra ® . However, compared to the first cited techniques, X-ray diffraction and NMR necessitate a more elaborated sample preparation and are therefore only performed by well trained analysts.…”

Section: Since Its Approval By the American Food And Drug Agency (Fdamentioning

confidence: 99%

“…Raman microspectroscopy imaging is widely used in the biomedical field. Among others, it has been recently used to predict the cellular response to cisplatin in lung adenocarcinoma [12] and to study the molecular interactions between zoledronic acid and bone [13]. It is also used in the pharmaceutical field since it necessitates a negligible sample preparation (e.g.…”

Section: Since Its Approval By the American Food And Drug Agency (Fdamentioning

confidence: 99%

Detection of counterfeit Viagra® by Raman microspectroscopy imaging and multivariate analysis

Sacré

Deconinck

Saerens

et al. 2011

Journal of Pharmaceutical and Biomedical Analysis

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During the past years, pharmaceutical counterfeiting was mainly a problem of developing countries with weak enforcement and inspection programs. However, Europe and North America are more and more confronted with the counterfeiting problem. During this study, 26 counterfeits and imitations of Viagra ® tablets and 8 genuine tablets of Viagra ® were analysed by Raman microspectroscopy imaging.After unfolding the data, three maps are combined per sample and a first PCA is realised on these data. Then, the first principal components of each sample are assembled. The exploratory and classification analysis are performed on that matrix.PCA was applied as exploratory analysis tool on different spectral ranges to detect counterfeit medicines based on the full spectra (200-1800 cm After the exploratory analysis, three different classification algorithms were applied on the full spectra dataset: linear discriminant analysis, k-nearest neighbour and soft independent modelling of class analogy.PCA analysis of the 830-880cm -1 spectral region discriminated genuine samples while the multivariate analysis of the spectral region between 1200-1290 cm -1 returns no satisfactory results.A good discrimination of genuine samples was obtained with multivariate analysis of the full spectra region (200-1800 cm -1). Application of the k-NN and SIMCA algorithm returned 100% correct classification during both internal and external validation.

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Molecular interactions between zoledronic acid and bone: An in vitro Raman microspectroscopic study

Cited by 38 publications

References 44 publications

Phosphate group vibrational signatures of the osteoporosis drug alendronate

Phosphate group vibrational signatures of the osteoporosis drug alendronate

Risedronate adsorption on bioactive glass surface for applications as bone biomaterial

Detection of counterfeit Viagra® by Raman microspectroscopy imaging and multivariate analysis

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