Molecular interactions and antimicrobial activity of curcumin (Curcuma longa) loaded polyacrylonitrile films

Govindaraj, Premika; Kandasubramanian, Balasubramanian; Kodam, Kisan M.

doi:10.1016/j.matchemphys.2014.06.040

Cited by 59 publications

(20 citation statements)

References 26 publications

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“…The release kinetics of curcumin from microcapsules was studied using two mathematical models, Higuchi model and Korsmeyer–Peppas model. 39 Higuchi model equation (3) for drug release from insoluble matrix is based on the diffusion Fick’s laws where Q t is the quantum of release drug in t and K is the release constant.…”

Section: Methodsmentioning

confidence: 99%

Curcumin delivered through bovine serum albumin/polysaccharides multilayered microcapsules

et al. 2015

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The aim of the paper is to obtain and characterize k-carrageenan-chitosan dual hydrogel multilayers shell BSA gel microcapsules, as a carrier for curcumin, and as a possible antitumoral agent in biological studies. We used the CaCO3 template to synthesize non-toxic CaCO3/BSA particles as microtemplates by coprecipitating a CaCl2 solution that contains dissolved BSA, with an equimolar Na2CO3 solution. The microcapsules shell is assembled through a layer-by-layer deposition technique of calcium cross-linked k-carrageenan hydrogel alternating with polyelectrolite complex hydrogel formed via electrostatic interactions between k-carrageenan and chitosan. After the removal of CaCO3 through Ca(2+) complexation with EDTA, and by a slightly treatment with HCl diluted solution, the BSA core is turned into a BSA gel through a thermal treatment. The BSA gel microcapsules were then loaded with curcumin, through a diffusion process from curcumin ethanolic solution. All the synthesized particles and microcapsules were stucturally characterized by: Fourier Transform Infrared Spectroscopy, UV-Vis Spectrometry, X-ray diffraction, thermal analysis, fluorescence spectroscopy, fluorescence optical microscopy, confocal laser scanning microscopy and scanning electron microscopy. The behavior of curcumin loaded microcapsules in media of different pH (SGF, SIF and PBS) was studied in order to reveal the kinetics and the release profile of curcumin. The in vitro evaluation of the antitumoral activity of encapsulated curcumin microcapsules on HeLa cell line and the primary culture of mesenchymal stem cells is the main reason of the microcapsules synthesis as BSA-based vehicle meant to enhance the biodisponibility of curcumin, whose anti-tumor, anti-oxidant and anti-inflammatory properties are well known.

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Section: Methodsmentioning

confidence: 99%

Curcumin delivered through bovine serum albumin/polysaccharides multilayered microcapsules

et al. 2015

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“…Furthermore, for the first time we report the preparation of the wet-spun fibers loaded with two drugs, curcumin and vitamin E acetate which exhibit various functions, such as anti-aging, biocompatibility, antitumor, anti-inflammatory effects. Besides, the curcumin and vitamin E acetate are all relatively stable and they can be used as models to analyze the release behaviors of two drugs from wet-spun fibers and may provide reference for the development of multifunctional textiles in the biomedical material field and could find potential applications in health care underwear, surgical dressings and dialysis materials [46,47].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

A novel multifunctional biomedical material based on polyacrylonitrile: Preparation and characterization

Bremner

et al. 2016

Materials Science and Engineering: C

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Wet spun microfibers have great potential in the design of multifunctional controlled release materials. Curcumin (Cur) and vitamin E acetate (Vit. E Ac) were used as a model drug system to evaluate the potential application of the drug-loaded microfiber system for enhanced delivery. The drugs and polyacrylonitrile (PAN) were blended together and spun to produce the target drug-loaded microfiber using an improved wet-spinning method and then the microfibers were successfully woven into fabrics. Morphological, mechanical properties, thermal behavior, drug release performance characteristics, and cytocompatibility were determined. The drug-loaded microfiber had a lobed "kidney" shape with a height of 50-100 μm and width of 100-200 μm. The addition of Cur and Vit. E Ac had a great influence on the surface and cross section structure of the microfiber, leading to a rough surface having microvoids. X-ray diffraction and Fourier transform infrared spectroscopy indicated that the drugs were successfully encapsulated and dispersed evenly in the microfilament fiber. After drug loading, the mechanical performance of the microfilament changed, with the breaking strength improved slightly, but the tensile elongation increased significantly. Thermogravimetric results showed that the drug load had no apparent adverse effect on the thermal properties of the microfibers. However, drug release from the fiber, as determined through in-vitro experiments, is relatively low and this property is maintained over time. Furthermore, in-vitro cytocompatibility testing showed that no cytotoxicity on the L929 cells was found up to 5% and 10% respectively of the theoretical drug loading content (TDLC) of curcumin and vitamin E acetate. This study provides reference data to aid the development of multifunctional textiles and to explore their use in the biomedical material field.

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“…Curcumin analogue is a versatile lead molecule in the pharmaceutical development and has a wide range of biological activities, especially in the 3,5-diarylidene-4-piperidone system, such as anti-microbial, 4,5 topoisomerase IIα inhibition, 6 cytotoxic activity, 7,8 HIV-I multiplication, 9 anti-carcinogenic and anti--angiogenesis agents, 10 anti-malarial, 11 anti-oxidant, 12 anti-inflammatory, 13 anti--cancer 14 and anti-mycobacterium tuberculosis. 15 In the present study, the 3,5--diarylidene-4-piperidone function with sulphonamide and peptide substitutions are introduced, which are quite stable, encouraging chemists to utilize this stable fragment in bioactive moieties to synthesize new compounds possessing biological activities.…”

Section: S I N G a R A M Et Almentioning

confidence: 99%

Synthesis and antimicrobial activity of new 3,5-diarylidene-4-piperidone derivatives

Singaram

Marimuthu

Baskaran³

et al. 2016

JSCS

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Three series of heteroaromatic analogues (twenty seven compounds) with monoketone linkers were synthesized and evaluated for their antimicrobial activity against six microbial strains. Among them, 3,5-dibenzylidene-1-[(3,5dichloro-2-hydroxyphenyl)sulfonyl]piperidin-4-one (5e) showed the best antifungal activity against Aspergillus niger and A. fumigatus. Structural elucidation of the synthesized compounds was realised based on various spectroscopic methods.

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Molecular interactions and antimicrobial activity of curcumin (Curcuma longa) loaded polyacrylonitrile films

Cited by 59 publications

References 26 publications

Curcumin delivered through bovine serum albumin/polysaccharides multilayered microcapsules

Curcumin delivered through bovine serum albumin/polysaccharides multilayered microcapsules

A novel multifunctional biomedical material based on polyacrylonitrile: Preparation and characterization

Synthesis and antimicrobial activity of new 3,5-diarylidene-4-piperidone derivatives

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