Molecular interaction and localization of tocotrienol-rich fraction (TRF) within the matrices of lipid nanoparticles: Evidence studies by Differential Scanning Calorimetry (DSC) and Proton Nuclear Magnetic Resonance spectroscopy (1H NMR)

Ali, Hazem; Elsayed, Khalid; Sylvester, Paul W.; Nazzal, Sami

doi:10.1016/j.colsurfb.2010.02.003

Cited by 56 publications

(33 citation statements)

References 37 publications

(64 reference statements)

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“…NE showed the smallest particle size as well as lowest PI value. These findings are in agreement with that reported by Garcia-Fuentes et al (2005) and Ali et al (2010). Our results are in contrast to the work of Lin et al (2007) who found that particle size of NLC prepared using monocaprate (solid lipid), and medium chain triglyceride (liquid lipid) depended on the content of liquid lipid loading.…”

Section: Physicochemical Characterisation Of Sln Nlc and Necontrasting

confidence: 57%

Development of nanostructured lipid carriers for controlled delivery of mefenamic acid

Khurana

Bedi

Jain

2012

IJBNN

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This study was aimed to develop nanostructured lipid carriers (NLC) for the possible delivery of mefenamic acid. This study describes the effect of liquid lipid concentration on the characteristics of NLC such as particle size, polydispersity index, zeta potential, drug entrapment efficiency, and occlusivity index. Transmission electron microscopy revealed nearly spherical shape NLC with negligible effect of liquid lipid content on the particle morphology. The differential scanning calorimetry demonstrated a depression in the melting point and crystallinity index of the NLC with an increase in the amount of liquid lipid. The in vitro drug release studies demonstrated that solid lipid nanoparticle (0% oil), and NLC possessed a biphasic release pattern characterised by a rapid initial release followed by a sustained release, in comparison to nanoemulsions (100% oil) of which a nearly constant release was observed. Compared to NE and SLN, the excellent physical stability of NLC against drug leakage was seen.

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Section: Physicochemical Characterisation Of Sln Nlc and Necontrasting

confidence: 57%

Development of nanostructured lipid carriers for controlled delivery of mefenamic acid

Khurana

Bedi

Jain

2012

IJBNN

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“…The drug molecules are tightly bound to the carrier matrix at low concentrations, but when present in excess, they adhere to the carrier surface as a liquid phase, thus lowering the crystallinity . Addition of liquid lipid leads to suppression of crystallization temperature in NLCs (Ali et al 2010;Awad et al 2009;Jenning et al 2000c). Incorporation of a drug and/or inclusion of liquid lipids also lead to a decreased melting point, however, the reduced melting temperature is usually lower than the crystallization temperature .…”

Section: Crystallinity and Polymorphismmentioning

confidence: 96%

“…Bunjes et al (2002) suggested induced crystallization of triglycerides at higher temperatures due to its interactions with the stabilizer. The presence of partial glycerides and/or residues of long fatty acids in glycerides may reduce the supercooling tendency (Ali et al 2010;Bunjes et al 1996;.…”

Section: Crystallinity and Polymorphismmentioning

confidence: 99%

Characterization

Shah¹,

Eldridge²,

Palombo³

et al. 2014

Lipid Nanoparticles: Production, Characterization and Stability

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Lipid nanoparticles are known to present three features-a solid nature, lipid matrix and colloidal (or smaller) particle size. These features are theorized to impart controlled drug release, biocompatibility and improved drug dissolution to the colloidal carriers. Appropriate characterization of lipid nanoparticle formulations is required to allow for the development of dispersions with the desired properties for the intended application. The structural complexity and the colloidal size of the lipid nanoparticle dispersions make characterization a difficult task. The colloidal size of the particles alters physical features (e.g., increasing solubility and the tendency to form supercooled melts). The properties of bulk materials such as polymorphism and crystallinity may drastically change when these materials are dispersed into nanoparticles. Further complicating characterization is the potential co-existence of other colloidal structures such as micelles, vesicles and emulsions in the dispersions. A detailed characterization scheme is required to investigate the structure and behavior of these complex colloidal carriers. This chapter introduces a number of methods commonly applied for characterization of lipid nanoparticle dispersions. The main focus of the chapter is lipid nanoparticles, however the methods are often generic and occasional mention of their use in other colloidal structures is made.

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“…NLCs are composed of a blend of lipids in which lowmelting-point lipids are entrapped in the form of oily nanocompartments within a solid matrix [29,30]. Additional studies were performed to evaluate the long-term stability of the TRF-NLCs with respect to particle size and to assess the antiproliferative effects of TRF containing NLCs against the highly malignant +SA mammary epithelial cells grown in culture [27,28].…”

Section: Novel Delivery Systems To Increase Tocotrienol Bioavailabilitymentioning

confidence: 99%

“…Other investigations were conducted to develop and optimize a systemic delivery of TRF using colloidal drug carriers classified as nanostructured lipid carriers (NLCs) [27,28]. NLCs are composed of a blend of lipids in which lowmelting-point lipids are entrapped in the form of oily nanocompartments within a solid matrix [29,30].…”

Section: Novel Delivery Systems To Increase Tocotrienol Bioavailabilitymentioning

confidence: 99%

The Value of Tocotrienols in the Prevention and Treatment of Cancer

Sylvester

Kaddoumi

Nazzal

et al. 2010

Journal of the American College of Nutrition

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Tocopherols and tocotrienols represent the 2 subgroups that make up the vitamin E family of compounds, but only tocotrienols display potent anticancer activity. Although in vitro experimental evidence has been very promising, oral supplementation of tocotrienols in animal and human studies has produced inconsistent results. However, recent studies have now clarified the reasons for these discrepancies observed between in vitro and in vivo studies. Oral absorption of tocotrienols into the circulation is mediated in large part by carrier transporter systems that display saturation and apparently down-regulation when exposed to high concentrations of tocotrienols. To circumvent these limitations in oral absorption of tocotrienols, investigators have developed novel prodrug derivatives and nanoparticle delivery systems that greatly enhance tocotrienol bioavailability and therapeutic responsiveness. Additional studies have also demonstrated that combined treatment of tocotrienols with other traditional chemotherapeutic agents results in a synergistic anticancer response, and this synergistic response was further enhanced when these agents were encapsulated in a nanoparticle delivery system. Taken together, these findings clarify the limitations of oral tocotrienol administration and provide novel alternative drug-delivery systems that circumvent these limitations and greatly enhance the therapeutic effectiveness of tocotrienols in the prevention and treatment of cancer.

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Molecular interaction and localization of tocotrienol-rich fraction (TRF) within the matrices of lipid nanoparticles: Evidence studies by Differential Scanning Calorimetry (DSC) and Proton Nuclear Magnetic Resonance spectroscopy (1H NMR)

Cited by 56 publications

References 37 publications

Development of nanostructured lipid carriers for controlled delivery of mefenamic acid

Development of nanostructured lipid carriers for controlled delivery of mefenamic acid

Characterization

The Value of Tocotrienols in the Prevention and Treatment of Cancer

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