Molecular insights into quality and authentication of sheep meat from proteomics and metabolomics

Zhang, Renyu; Paván, E.; Ross, Alastair B.; Deb‐Choudhury, Santanu; Dixit, Yash; Mungure, Tanyaradzwa E.; Realini, C.E.; Cao, Mingshu; Farouk, M.M.

doi:10.1016/j.jprot.2023.104836

Cited by 17 publications

(6 citation statements)

References 179 publications

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“…In this case, proteomics and metabolomics are useful approaches since they focus on the analysis of proteins and metabolites, rather than DNA, which may not always correlate with corresponding downstream protein expression and translation (Weckwerth, 2011a , 2011b ). Proteomics and metabolomics are gaining popularity among researchers who want to understand variations in FE and quality of carcass and meat (Zhang et al., 2023 ). Moreover, integrating genomics with proteomics and metabolomics can discover markers and underlying biological or biochemical mechanisms related with FE, carcass quality, and meat quality attributes without having to know anything about the production or processing conditions that generate differences in FE or meat qualities (Purslow et al., 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Insights into the influence of diet and genetics on feed efficiency and meat production in sheep

Chacko Kaitholil,

Mooney,

Aubry

et al. 2023

Animal Genetics

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Feed costs and carcass yields affect the profitability and sustainability of sheep production. Therefore, it is crucial to select animals with a higher feed efficiency and high‐quality meat production. This study focuses on the impact of dietary and genetic factors on production traits such as feed efficiency, carcass quality, and meat quality. Diets promote optimal sheep growth and development and provide sufficient protein can lead to higher‐quality meat. However, establishing an optimized production system requires careful consideration and balance of dietary parameters. This includes ensuring adequate protein intake and feeding diets with higher intestinal absorption rates to enhance nutrient absorption in the gut. The study identifies specific genes, such as Callipyge, Calpastatin, and Myostatin, and the presence of causal mutations in these genes, as factors influencing animal growth rates, feed efficiency, and meat fatty acid profiles. Additionally, variants of other reported genes, including PIGY, UCP1, MEF2B, TNNC2, FABP4, SCD, FASN, ADCY8, ME1, CA1, GLIS1, IL1RAPL1, SOX5, SOX6, and IGF1, show potential as markers for sheep selection. A meta‐analysis of reported heritability estimates reveals that residual feed intake (0.27 ± 0.07), hot carcass weight (0.26 ± 0.05), dressing percentage (0.23 ± 0.05), and intramuscular fat content (0.45 ± 0.04) are moderately to highly heritable traits. This suggests that these traits are less influenced by environmental factors and could be improved through genetic selection. Additionally, positive genetic correlations exist between body weight and hot carcass weight (0.91 ± 0.06), dressing percentage (0.35 ± 0.15), and shear force (0.27 ± 0.24), indicating that selecting for higher body weight could lead to favorable changes in carcass quality, and meat quality.

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Section: Resultsmentioning

confidence: 99%

Insights into the influence of diet and genetics on feed efficiency and meat production in sheep

Chacko Kaitholil,

Mooney,

Aubry

et al. 2023

Animal Genetics

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“…It has been shown that PKM2 protein can be inactivated by interaction with tyrosine-phosphorylated proteins or by post-translational modifications such as phosphorylation, acetylation, and oxidation, and its role in cancer and as a causative factor for PSE meat has been demonstrated ( Israelsen et al, 2013 ; Iqbal et al, 2014 ; Nath and Mukherjee, 2014 ). Differences in the expression levels of PKM2 in pectoral and hamstring muscles affected meat quality, and PKM2 expression was positively correlated with chicken meat quality( Ruiqi Fu et al, 2013 ).It has been shown that PGM1 is an enzyme that regulates glucose metabolism, which is associated with muscle development, while a deficiency of PGM1 results in congenital dysglycosylation and glycogen storage disease, manifested by short stature ( Pelletier et al, 2012 ; Bae et al, 2014 ); in terms of meat quality, PGM1 is negatively correlated with meat pH and positively correlated with L* and drip loss, while it is also associated with fat deposition and pork odor ( López-Pedrouso et al, 2020 ; Gagaoua et al, 2021 ; Zhang et al, 2023 ). The PurH gene is a bifunctional enzyme with the catalytic activity of aminoimidazolecarbamoyl ribonucleotide transcarboxylase and hypoxanthine ribonucleotide cyclization hydrolase.…”

Section: Discussionmentioning

confidence: 99%

Integrating proteomics and metabolomics to elucidate the molecular network regulating of inosine monophosphate-specific deposition in Jingyuan chicken

Huang,

Cai,

Zhang

et al. 2023

Poultry Science

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“…Recent strides in omics techniques have revolutionized the analysis of proteins and metabolites in sheep meat, elevating the precision of quality assessment and confirming meat authenticity at a molecular level. These advancements hold significant promise for augmenting sheep meat quality [75]. In similar environmental contexts, genetic background emerges as a critical determinant influencing meat production [76].…”

Section: Meat Traitsmentioning

confidence: 99%

Pan-Omics in Sheep: Unveiling Genetic Landscapes

Li,

Lu,

Gao

et al. 2024

Animals

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Multi-omics-integrated analysis, known as panomics, represents an advanced methodology that harnesses various high-throughput technologies encompassing genomics, epigenomics, transcriptomics, proteomics, and metabolomics. Sheep, playing a pivotal role in agricultural sectors due to their substantial economic importance, have witnessed remarkable advancements in genetic breeding through the amalgamation of multiomics analyses, particularly with the evolution of high-throughput technologies. This integrative approach has established a robust theoretical foundation, enabling a deeper understanding of sheep genetics and fostering improvements in breeding strategies. The comprehensive insights obtained through this approach shed light on diverse facets of sheep development, including growth, reproduction, disease resistance, and the quality of livestock products. This review primarily focuses on the application of principal omics analysis technologies in sheep, emphasizing correlation studies between multiomics data and specific traits such as meat quality, wool characteristics, and reproductive features. Additionally, this paper anticipates forthcoming trends and potential developments in this field.

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Molecular insights into quality and authentication of sheep meat from proteomics and metabolomics

Cited by 17 publications

References 179 publications

Insights into the influence of diet and genetics on feed efficiency and meat production in sheep

Insights into the influence of diet and genetics on feed efficiency and meat production in sheep

Integrating proteomics and metabolomics to elucidate the molecular network regulating of inosine monophosphate-specific deposition in Jingyuan chicken

Pan-Omics in Sheep: Unveiling Genetic Landscapes

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