Molecular Insight into Gut Microbiota and Rheumatoid Arthritis

Wu, Xiaohao; He, Bing; Liu, Jin; Feng, Hui; Ma, Yonghong; Li, Defang; Guo, Baosheng; Liang, Chao; Dang, Lei; Wang, Luyao; Tian, Jing; Zhu, Hailong; Xiao, Lianbo; Lü, Cheng; Lu, Aiping; Zhang, Ge

doi:10.3390/ijms17030431

Cited by 66 publications

(43 citation statements)

References 54 publications

(57 reference statements)

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“…For example, studies reported that in the RA patients, the levels of opportunistic pathogens such as Enterobacterium and Staphylococcus were increased while reduced levels were observed for the strains such as Lactobacillus, Bifidobacterium, Bacteroides [120]. Similarly, reduced Firmicutes/Bacteriodetes ratio has been reported in the intestinal microenvironment of patients with SLE [121]. Furthermore, studies were performed and it was found that probiotics interventions affect the various anti-inflammatory and immune-modulatory pathways by which various proteins like mucin, HSP-70, anti-inflammatory mediators have been released that help in the alleviation of the auto-immune disorders [122].…”

Section: Role Of Metabiotics In Protecting Auto-immunitymentioning

confidence: 99%

Metabiotics: The Functional Metabolic Signatures of Probiotics: Current State-of-Art and Future Research Priorities—Metabiotics: Probiotics Effector Molecules

Singh¹,

Vishwakarma²,

Singhal³

2018

ABB

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The intricate "orchestered molecular conversation" between the host and gut microbiome is one of the most dynamic research areas in recent years. The rhythmic chemical cross talk in the form of bioactive metabolites and signalling molecules synthesized by gut microbiome plays a significant role for the modulation of human health in diversified ways. They are recognized as low molecular weight (LMW) molecules having versatile chemical attributes. They possess magnificent capability of interacting with surrounding environment and controlling the genes for various genetic, biochemical and physiological functions for maintaining the homeostasis that is now-a-days termed as "small molecules microbes originated (SMOM) homeostasis" in the host. These metabolic signatures have close structural and functional resemblance with small molecules synthesized by host eukaryotic cells and dietary components. Therefore, they may be considered as universalized metabolites contributing to the remarkable phenomenon of epigenetic regulation, cell to cell communication and stability of genome manifesting the overall growth and development of the host and known as "metabiotics". The wide panorama of utilization of probiotics is continuously expanding and conferring the major health benefits through metabiotic components are gaining tremendous momentum therefore recognized as "hidden soldiers" of the body. Therefore firstly, we outline the need and types of metabiotic molecules and depicting their role in human health. Then, we summarize their preventive and therapeutic avenues in various diseases and finally, we propose the current technological interventions, bottlenecks and future perspectives in this field that are implied for accelerating their comprehensive understanding and utilization at industrial scale.

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Section: Role Of Metabiotics In Protecting Auto-immunitymentioning

confidence: 99%

Metabiotics: The Functional Metabolic Signatures of Probiotics: Current State-of-Art and Future Research Priorities—Metabiotics: Probiotics Effector Molecules

Singh¹,

Vishwakarma²,

Singhal³

2018

ABB

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“…The interaction between the digestive tract microbes and the host is one of the factors which, to a great extent, determine the patient's condition [8,9]. The analyses carried out so far show that changes in gut microbiota composition account for many metabolic disorders, including obesity [10][11][12], inflammatory bowel diseases [13,14], rheumatoid arthritis [15,16] or type 2 diabetes [17,18]. The World Microbiome Project provided information on how race, place of residence, and diet affect gut microbiota composition [19].…”

Section: Introductionmentioning

confidence: 99%

Gut microbiome as a biomarker of cardiometabolic disorders

Gózd-Barszczewska¹,

Kozioł-Montewka²,

Barszczewski³

et al. 2017

Ann Agric Environ Med.

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Introduction and objective. Cardiovascular diseases are the leading cause of death in Europe and worldwide. One of the most important risk factors for atherosclerosis are lipid metabolism disorders, in particular hipercholesterolaemia. The aim of the study was to determine the correlation between gut microbiota composition and atherosclerosis risk factors, so in order that it might be used as a biomarker for coronary artery disease diagnosis. Material and method. The study involved middle-aged men in eastern Poland with central obesity (n=20), subjects with atherosclerosis (n=15) and those with no cardiovascular diseases (n=5). The gut microbiota composition was determined using tag-encoded 16S rRNA gene using Illuminal MiSeq. Data were analyzed with the use of t-test. Results. Firmicutes (49.26%) and Bacteroidetes (44.46%) were the dominant Phyla in the middle-aged men in eastern Poland. Subjects with improper levels of total cholesterol were enriched in Prevotella (p=0.03) and decreased level of Clostridium (p=0.02). They also showed a falling tendency in Faecalibacterium (p=0.07). An upward trend was observed in Prevotella (p=0.07) in subjects with improper LDL-C values. Conclusions. The study showed that intestinal microbiome is likely to play a role in the pathogenesis of atherosclerosis through its role in lipid metabolism. Bacterial genera of particular importance were Prevotella, Bacteroides, Clostridium, Faecalibacterium. However, further studies involving larger groups of subjects are required to confirm these observations.

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“…Эта проблема детально рассмотрена в серии обзоров [156][157][158]. Обратимся лишь к некоторым данным, касаю-щимся потенциальной роли кишечной микробиоты в раз-витии РА.…”

Section: фак торы внешней средыunclassified

Problems of Rheumatoid Arthritis Immunopathology: Evolution of the Disease

Насонов¹

2017

rsp

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Molecular Insight into Gut Microbiota and Rheumatoid Arthritis

Cited by 66 publications

References 54 publications

Metabiotics: The Functional Metabolic Signatures of Probiotics: Current State-of-Art and Future Research Priorities—Metabiotics: Probiotics Effector Molecules

Metabiotics: The Functional Metabolic Signatures of Probiotics: Current State-of-Art and Future Research Priorities—Metabiotics: Probiotics Effector Molecules

Gut microbiome as a biomarker of cardiometabolic disorders

Problems of Rheumatoid Arthritis Immunopathology: Evolution of the Disease

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