Molecular imprinting of protein in Pickering emulsion

Shen, Xiantao; Zhou, Tongchang; Ye, Lei

doi:10.1039/c2cc33572g

Cited by 99 publications

(59 citation statements)

References 30 publications

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“…Using seeded suspension polymerization, MIP microspheres with a narrow size distribution can be obtained, although the synthetic process is more complicated due to the multistage swelling process. More recently, Ye and coworkers reported the use of Pickering emulsion polymerization to synthesize MIP microspheres [55][56][57]. In these Pickering emulsion systems, solid particles are used as stabilizers to replace the surfactants used in conventional suspension polymerization.…”

Section: Preparation Of Mip Nanoparticles and Microspheresmentioning

confidence: 98%

Synthetic Strategies in Molecular Imprinting

2015

Molecularly Imprinted Polymers in Biotechnology

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This chapter introduces the basic principle and the synthetic aspects of molecular imprinting. First, the use of a molecular template to guide the location of functional groups inside molecularly imprinted cavities is explained. Three different mechanisms that ensure a molecular template associates with functional monomers or the imprinted polymers, that is, through reversible covalent, noncovalent, and sacrificial covalent bonds, are then described. The main focus is put on noncovalent molecular imprinting using free radical polymerization. The merits of using classical radical polymerization and more sophisticated, controlled radical polymerization are analyzed. After these synthetic chemistry aspects, the chapter continues to discuss the different polymerization processes that can be used to prepare well-defined polymer monoliths, microspheres, and nanoparticles. New top-down processing techniques that produce micro- and nanopatterns of imprinted polymers are also reviewed. The chapter finishes with a brief introduction to using imprinted polymers as building blocks to construct new functional materials and devices, which we consider as one important direction for further development.

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Section: Preparation Of Mip Nanoparticles and Microspheresmentioning

confidence: 98%

Synthetic Strategies in Molecular Imprinting

2015

Molecularly Imprinted Polymers in Biotechnology

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“…The effects of the solvent polarity on porosity were also reported in other studies [55][56][57][58][59][60]. Use of the Pickering radical polymerization scheme to increase the MI polymer porosity has also been reported [61][62][63][64][65][66][67]. Also polymers can be used as porogens [37,38].…”

Section: Key Termsmentioning

confidence: 64%

Molecularly Imprinted Polymeric Micro- and Nano-Particles for the Targeted Delivery of Active Molecules

Gagliardi

Mazzolai

2015

Future Med. Chem.

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Molecular imprinting (MI) represents a strategy to introduce a 'molecular memory' in a polymeric system obtaining materials with specific recognition properties. MI particles can be used as drug delivery systems providing a targeted release and thus reducing the side effects. The introduction of molecular recognition properties on a polymeric drug carrier represents a challenge in the development of targeted delivery systems to increase their efficiency. This review will summarize the limited number of drug delivery MI particles described in the literature along with an overview of potential solutions for a larger exploitation of MI particles as targeted drug delivery carriers. Molecularly imprinted drug carriers can be considered interesting candidates to significantly improve the efficiency of a controlled drug treatment.

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“…To investigate the influence of template and monomer dimerization on final MIP-template recognition, studies on, for example, nicotine dimerization during the pre-polymerization stage helped to explain the unusual behavior observed in final MIP-template rebinding [107,108]. To investigate the influence of template and monomer dimerization on final MIP-template recognition, studies on, for example, nicotine dimerization during the pre-polymerization stage helped to explain the unusual behavior observed in final MIP-template rebinding [107,108].…”

Section: Molecular Dynamics Simulationsmentioning

confidence: 99%

Molecularly Imprinted Polymers in Biotechnology

Mattìasson¹,

Ye²

2015

Advances in Biochemical Engineering/Biotechnology

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Aims and ScopeThis book series reviews current trends in modern biotechnology and biochemical engineering. Its aim is to cover all aspects of these interdisciplinary disciplines, where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, molecular biology, chemical engineering and computer science.Volumes are organized topically and provide a comprehensive discussion of developments in the field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification.In general, volumes are edited by well-known guest editors. The series editor and publisher will, however, always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.In references, Advances in Biochemical Engineering/Biotechnology is abbreviated as Adv. Biochem. Engin./Biotechnol. and cited as a journal.More information about this series at

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Molecular imprinting of protein in Pickering emulsion

Abstract: A new strategy of molecular imprinting to prepare spherical hydrogels via water-in-oil Pickering emulsion polymerization was developed. The imprinted hydrogels exhibited fast adsorption kinetics and significant selectivity for the target protein.

Cited by 99 publications

References 30 publications

Synthetic Strategies in Molecular Imprinting

Synthetic Strategies in Molecular Imprinting

Molecularly Imprinted Polymeric Micro- and Nano-Particles for the Targeted Delivery of Active Molecules

Molecularly Imprinted Polymers in Biotechnology

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