Molecular Imprinting of Biologically Active Steroidal Systems

Enhanced capacities and selectivities for cholesterol in aqueous media by molecular imprinting: role of novel cross-linkers

“…The importance of lowering cholesterol is well established [1][2][3]. In view of the problems associated with the administration of cholesterol lowering agents such as statins, there is an increasing emphasis on use of polymeric adsorbents as sequesterants for bile acids as well as cholesterol.…”

“…Further, for binding in aqueous media, only the later can be exploited. Imprinting using a covalent approach is reported to be more efficient than that using a non-covalent approach [3,6]. non-covalent imprinting methodology has also been extensively investigated for the imprinting of cholesterol and subsequent rebinding from non-aqueous media (Table 1).…”

“…The deleterious effect of cholesterol on human health is well documented [1][2][3]. Therefore attempts are being made to develop cholesterol or bile salt selective adsorbents that are biocompatible and clinically efficient [1,2].…”

Molecularly imprinted polymers for drug delivery

“…A comprehensive review about MIPs for steroids and, in particular, for cholesterol has been carried out by Davidson and Hayes [89]. Polymer networks containing imprinted cyclodextrins were found particularly useful to enhance their capability to form inclusion complexes with cholesterol [90].…”

Synthesis of Novel Triazole Derivatives of Methyl 3-Oxocholanate Using Microwave Irradiation

“…[7][8][9][10][11][12][13] Recently, steroidal building blocks have attracted the interest of research groups in many branches of science and technology, such as the medical and pharmacological fields, supramolecular chemistry and nanotechnology. [14][15][16][17] Microwave-assisted organic synthesis is an important technique in green synthetic chemistry. It possesses useful attributes, such as ease of manipulation, enhanced reaction rates, clean reaction outcomes and high yields.…”