Molecular imprinting of amino acid derivatives in macroporous polymers

Sellergren, Börje; Ekberg, Björn; Mosbach, Klaus

doi:10.1016/s0021-9673(01)95464-0

Cited by 153 publications

(59 citation statements)

References 17 publications

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“…The preparation of molecularly imprinted polymers (MIP) typically involves three steps: first, a monomer-template [M-T] complex is formed via self-assembly; next, the M-T complex is polymerized with an excess of cross-linker to form a rigid polymer; finally, the template is removed, leaving behind binding cavities which are complementary in shape and functional group to the template [2]. The vast majority of MIP is based on the use of organic acrylate-type polymers: a standard procedure using a methacrylate monomer, with a nearly optimal ratio to the template molecule and crosslinker, is described in numerous works [2][3][4][5][6][7][8]. The broad applicability of methacrylic acid (MAA) as a functional monomer in MIP production is related to the fact that the carboxylic acid group serves well as a hydrogen bond and proton donor as well as a hydrogen bond acceptor [9].…”

Section: Introductionmentioning

confidence: 99%

Imidazolium-based functional monomers for the imprinting of the anti-inflammatory drug naproxen: Comparison of acrylic and sol–gel approaches

Kadhirvel

Azenha

Shinde

et al. 2013

Journal of Chromatography A

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a b s t r a c tImidazolium-based monomers were, for the first time, employed in a comprehensive investigation of the molecular imprinting process of naproxen in both acrylic and sol-gel tridimensional networks. To this end, molecularly imprinted polymer (MIP) and xerogel (MIX) were both optimized for performance, by testing different porogen, template speciation and component ratios. The developed imprints were characterized for their pore properties (nitrogen adsorption analysis), site heterogeneity, binding properties and other performance parameters such as the imprinting factor, selectivity (HPLC column tests), column efficiency and mass transfer kinetics (frontal analysis study). MIP exhibited mesoporosity (D p 29 nm), whereas MIX did not, which was reflected in both the lower number of accessible imprinted sites (4.9 mol/g versus 3.7 mol/g) and the slower binding/dissociation in MIX. The naproxen/ibuprofen selectivity ratio was estimated as 6.2 for the MIX and 2.5 for the MIP. Given the high importance of capacity and fast mass transfer in typical applications of imprinted materials, and the satisfactory selectivity of MIP, it can be concluded that the acrylic approach was globally the most advantageous. Still, the remarkably high selectivity of MIX and its reasonable capacity demonstrate that future work devoted to further optimization of both formats is worthwhile.

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Section: Introductionmentioning

confidence: 99%

Imidazolium-based functional monomers for the imprinting of the anti-inflammatory drug naproxen: Comparison of acrylic and sol–gel approaches

Kadhirvel

Azenha

Shinde

et al. 2013

Journal of Chromatography A

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“…The use of conventional MI [1][2][3][4][5] techniques for providing a material with selective recognition for water-soluble ionic compounds is difficult, because in this technique the organic solvent is used as a porogenic solvent. Therefore, to overcome this difficulty, we used the interval immobilization technique in our previous studies.…”

Section: Introductionmentioning

confidence: 99%

Selective Adsorption of Water-soluble Ionic Compounds by an Interval Immobilization Technique Based on Molecular Imprinting

et al. 2008

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“…49,50 Esta última é misturada directamente com um ou mais monómeros funcionais, ocorrendo posteriormente a polimerização. Após esta etapa, a molécula-molde pode ser facilmente extraída do polímero e reciclada.…”

Section: Moldagem Não-covalenteunclassified

Polímeros com capacidade de reconhecimento molecular no controlo da libertação de fármacos. Parte 1: síntese e caracterização

Sousa¹,

Barbosa²

2009

Quím. Nova

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Recebido em 30/8/08; aceito em 20/1/09; publicado na web em 10/8/09MOLECULARLY IMPRINTED POLYMERS FOR CONTROLLING DRUG RELEASE. PART 1: SYNTHESIS AND CHARACTERIZATION. Molecularly imprinted polymers (MIPs) consist of synthetic macromolecular matrix, obtained through molecular imprinting-based methods that show ability to selectively recognize important biological molecules and its application in the drug delivery field is under development. In the present review the main aspects related to the synthesis and characterization of MIPs are studied. The fundamental variables participating in the synthesis process, such as template molecule, functional monomers, cross-linking agents, solvents and imprinting approaches are discussed. Moreover, the main available methods for MIPs chemical and morphological characterization are presented and the importance of the obtained information is discussed.Keywords: molecularly imprinted polymers (MIPs); imprinting approaches; MIPs characterization. INTRODUÇÃOO reconhecimento molecular é definido como a capacidade de uma molécula se ligar a outra que apresenta uma forma complementar com a primeira.1 Os polímeros com capacidade de reconhecimento molecular (designados na literatura anglo-saxónica molecularly imprinted polymers -MIPs) encontram-se actualmente bem definidos. Consistem em matrizes macromoleculares sintéticas, obtidas com base em métodos de moldagem molecular, que apresentam a capacidade de reconhecer selectivamente moléculas importantes do ponto de vista biológico, como fármacos, proteínas e biomoléculas.2-6 Com efeito, as tecnologias baseadas na moldagem molecular permitem disponibilizar sistemas poliméricos eficientes, com capacidade para reconhecer moléculas bioactivas específicas, em que a interacção depende das propriedades e da concentração da molécula-molde presente no meio circundante.O reconhecimento molecular constitui já uma ferramenta bem desenvolvida na área analítica, principalmente no que se refere à separação e quantificação de diferentes substâncias, como fármacos e moléculas bioactivas, presentes em matrizes mais ou menos complexas.7-10 Presentemente, encontram-se comercializados alguns produtos baseados nesta tecnologia.11,12 Embora estes materiais ainda não tenham alcançado uma aplicação clínica no domínio do controlo da libertação de fármacos, vários autores referem que esta tecnologia apresenta grande potencial no desenvolvimento de formas farmacêuticas mais adequadas.13-16 Outra razão que tem vindo a promover o interesse pelos MIPs reside no facto de estes poderem mimetizar receptores biológicos em estudos de desenvolvimento de novas substâncias com actividade farmacológica e também poderem detectar substâncias específicas em fluidos biológicos (como, por exemplo, nos testes de detecção de drogas de abuso).12,17 De acordo com Mosbach e Ramström, 18 esta especificidade é comparável à dos anticorpos monoclonais utilizados em técnicas imunológicas. O presente trabalho constitui uma revisão de conjunto relativa à síntese e caracterização de MIPs. No ...

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Molecular imprinting of amino acid derivatives in macroporous polymers

Cited by 153 publications

References 17 publications

Imidazolium-based functional monomers for the imprinting of the anti-inflammatory drug naproxen: Comparison of acrylic and sol–gel approaches

Imidazolium-based functional monomers for the imprinting of the anti-inflammatory drug naproxen: Comparison of acrylic and sol–gel approaches

Selective Adsorption of Water-soluble Ionic Compounds by an Interval Immobilization Technique Based on Molecular Imprinting

Polímeros com capacidade de reconhecimento molecular no controlo da libertação de fármacos. Parte 1: síntese e caracterização

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