1998
DOI: 10.1021/bk-1998-0703.ch002
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Molecular Imprinting for the Preparation of Enzyme-Analogous Polymers

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Cited by 17 publications
(12 citation statements)
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“…For successful imprinting, high affinity between the functional monomer and the template is necessary. In addition, complex stability constants log K higher than 3 are preferred to reach stoichiometric noncovalent imprinting whereby over 95% of template is complexed in the prepolymerization mixture. ,, Stronger ion-pairing and enhanced ternary complex formation in the prepolymerization mixture might in turn have an adverse effect on designated cavity formation during the polymerization step. Moreover, since the features reported for low concentrations in Table are retained at higher concentrations under prepolymerization conditions (Table ; see also Figure ), though to a lesser extent, we set out to prepare a series of MIPs and studied in detail their rebinding behavior as a function of the chain length on the ammonium-N of the TXA cations.…”
Section: Resultsmentioning
confidence: 99%
“…For successful imprinting, high affinity between the functional monomer and the template is necessary. In addition, complex stability constants log K higher than 3 are preferred to reach stoichiometric noncovalent imprinting whereby over 95% of template is complexed in the prepolymerization mixture. ,, Stronger ion-pairing and enhanced ternary complex formation in the prepolymerization mixture might in turn have an adverse effect on designated cavity formation during the polymerization step. Moreover, since the features reported for low concentrations in Table are retained at higher concentrations under prepolymerization conditions (Table ; see also Figure ), though to a lesser extent, we set out to prepare a series of MIPs and studied in detail their rebinding behavior as a function of the chain length on the ammonium-N of the TXA cations.…”
Section: Resultsmentioning
confidence: 99%
“…However, the latter problems can be largely overcome by the design and synthesis of ªsecond generationº functional monomers which are capable of much stronger interaction with particular functional groups of the template. Examples of such ªdesignerº monomers include polymerizable amidines (2), [13] amides of nitrogen heterocycles (3) [14] and (4), [15] 5-(4-vinyl)benzyloxy-1,3-bis[2-(3,3,4,4-tetramethyl-2,5-dioxaborolanyl)-phenylcarbomoyl]benzene (5) and 2-(4vinylphenyloxy)-3,5,6-trichlorobenzoquinone (6), [16] 2,6-diamidopyridines (7), [17] designed to form strong (in some cases stoichiometric) interactions with carboxylates and phospho- Table 1. Advantages and disadvantages of the main imprinting methodologies.…”
Section: Preparation Of Imprinted Polymersmentioning
confidence: 99%
“…These attributes compare favorably with other strategies for producing materials capable of molecular recognition including synthetic antibodies and rationally designed small molecule receptors . Consequently, MIPs have been utilized in a wide range of applications requiring binding and selectivity including as catalysts, enzyme models, chemical sensors, and supports for enantioselective separations 1 Schematic Representation of the Imprinting Process …”
Section: Introductionmentioning
confidence: 99%