Molecular Imprinted Polymer of Methacrylic Acid Functionalised β-Cyclodextrin for Selective Removal  of 2,4-Dichlorophenol

Surikumaran, Hemavathy; Mohamad, Sharifah; Sarih, Norazilawati Muhamad

doi:10.3390/ijms15046111

Cited by 46 publications

(30 citation statements)

References 65 publications

(63 reference statements)

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“…used a two‐step process of bulk polymerization . First, the authors effectively constructed the functional monomer of methacrylic acid functionalized β‐Cyclodextrin (MAA‐β‐CD) by bridging a methacrylic acid (MAA) and β‐CD using toluene‐2,4‐diisocyanate (TDI) by reacting the –OH group of MAA and one of the primary –OH groups of β‐CD; the similar studies of methacrylic acid functionalized β‐Cyclodextrin (MAA‐β‐CD) monomers were also described elsewhere . Second, the authors started fabricating the molecularly imprinted polymers for recognition of benzylparaben (BzP) in dimethylacetamide (DMAC) solvent with MAA‐β‐CD monomers along with trimethylolpropane trimethacrylate (TRIM) as a cross‐linking agent, benzyol peroxide (BPO) as initiator, and 2,2‐phenyl‐2‐propyl benzodithioate (PPDT) as a reversible addition fragmentation chain transfer polymerization (RAFT) agent.…”

Section: Introductionmentioning

confidence: 99%

State‐of‐the‐art applications of cyclodextrins as functional monomers in molecular imprinting techniques: a review

Lay

et al. 2016

J of Separation Science

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As a versatile tool in separation science, cyclodextrins and their derivatives, known as emerging functional monomers, have been used extensively in molecular imprinting techniques. The attributes of cyclodextrins and their derivatives are widely known to form host-guest inclusion complex processes between the polymer and template. The exploitation of the imprinting technique could produce a product of molecularly imprinted polymers, which are very robust with long-term stability, reliability, cost-efficiency, and selectivity. Hence, molecularly imprinted polymers have gained popularity in chemical separation and analysis. Molecularly imprinted polymers containing either cyclodextrin or its derivatives demonstrate superior binding effects for a target molecule. As noted in the previous studies, the functional monomers of cyclodextrins and their derivatives have been used in molecular imprinting for selective separation with a wide range of chemical compounds, including steroidals, amino acids, polysaccharides, drugs, plant hormones, proteins, pesticides, and plastic additives. Therefore, the main goal of this review is to illustrate the exotic applications of imprinting techniques employing cyclodextrins and their derivatives as single or binary functional monomers in synthesizing molecularly imprinted polymers in areas of separation science by reviewing some of the latest studies reported in the literature.

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Section: Introductionmentioning

confidence: 99%

State‐of‐the‐art applications of cyclodextrins as functional monomers in molecular imprinting techniques: a review

Lay

et al. 2016

J of Separation Science

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“…Mass and viscoelastic sensing of the haemostasis at non-molecular scales are the most substantial measures for brin polymerization in coagulation, platelets brinogen interactions and brinolytic processes. 37 Aer achieving completely hardened gel and template washing step, the surface imprinted cavities from heparin ultimately lead to fast kinetics, highly sensitive and accurate. As demonstrated in introduction Fig.…”

Section: Resultsmentioning

confidence: 99%

Ultra-sensitive detection of heparin via aPTT using plastic antibodies on QCM-D platform

Hussain

2015

RSC Adv.

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One of the challenges faced by today's clinics is unavailability of practical, precise and accurate determination of the most commonly used anti-coagulant 'heparin' in human blood/plasma in surgery. This is the first report of the application of a heparin imprinted thin film on a Quartz Crystal Microbalance with Dissipation (QCM-D) platform. Based on a novel, straight-forward and robust imprinting approach, a lowest volume consumption of 2 mL of real sample (of human plasma) has been demonstrated. This is a leap for launching spot testing for heparin sensing in laboratory practice. This approach could shorten the coagulation times to 48% and 45% for clinically important sensing range of heparin doses of 0.75 and 0.50 IU mL À1 respectively and could improve precision 3-fold (n ¼ 20 samples) compared to that of today's 'gold standard'. Activated partial thromboplastin time (aPTT) on the plastic antibodies based QCM-D platform for plasma with doses of heparin 0.75 IU mL À1 and 0.50 IU mL À1 yielded 6.5% and 5% lower %RSD respectively as compared to that of the 'gold standard'. The present studies could provide a launch pad to laboratory methods for ultra-refining of point of care (POC) settings in the perspectives of coagulation time shortening, precision of the method and sample volume consumption.

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“…where Co and Ce are the initial concentration and final concentration of cholesterol and β-sitosterol solution [4].…”

Section: Selectivity Of Mipmentioning

confidence: 99%

“…Currently, there is known polymeric material called smart material. The type of polymer is an adsorbent with high selectivity and can know the target compound selectively [4]. These polymers are molecularly imprinted polymers (MIPs) synthesized using molecular imprinting techniques that require template molecules as cavity printers in polymers [2].…”

Section: Introductionmentioning

confidence: 99%

Adsorption Capacity and Selectivity of Molecularly Imprinted Polymers towards β-Sitosterol

et al. 2019

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Molecularly imprinted polymers (MIP) as an adsorbent has been synthesized using β-sitosterol as molecule template on free radical polymerization reaction. The capacity and selectivity of the adsorption from MIP to β-sitosterol was studied in this study. The β-sitosterol concentration in the adsorption-desorption test and the MIP selectivity test were analyzed by UV-visible and HPLC. The MIP obtained from the synthesis results in a high adsorption capacity. Based on the Freundlich adsorption isothermal equation, the adsorption capacity (k) was found to be 1.24 mg/g. The MIP can adsorb 100 % β-sitosterol while cholesterol was only 3 %. The MIP is most selective to β-sitosterol, therefore, has high potential to apply as adsorbent at solid phase extraction method to isolate β-sitosterol from sample extract.

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Molecular Imprinted Polymer of Methacrylic Acid Functionalised β-Cyclodextrin for Selective Removal of 2,4-Dichlorophenol

Cited by 46 publications

References 65 publications

State‐of‐the‐art applications of cyclodextrins as functional monomers in molecular imprinting techniques: a review

State‐of‐the‐art applications of cyclodextrins as functional monomers in molecular imprinting techniques: a review

Ultra-sensitive detection of heparin via aPTT using plastic antibodies on QCM-D platform

Adsorption Capacity and Selectivity of Molecularly Imprinted Polymers towards β-Sitosterol

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