Molecular imaging of cannabis leaf tissue with MeV-SIMS method

Jenčič, Boštjan; Jeromel, Luka; Ogrinc, Nina; Vogel‐Mikuš, Katarina; Kovačec, Eva; Regvar, Marjana; Siketić, Zdravko; Vavpetič, Primož; Rupnik, Zdravko; Bučar, K.; Kelemen, Mitja; Kovač, Janez; Pelicon, Primož

doi:10.1016/j.nimb.2015.10.047

Cited by 20 publications

(12 citation statements)

References 13 publications

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“…The distribution of organic molecules with masses between 200 and 1000 Da in the grains and in the plant tissue sections are measured with a newly developed MeVSIMS method (Jenčič et al, 2016). This procedure is used to investigate secondary metabolites in plant samples for the first time, and the dedicated sample preparation method is under development for different types of plant material.…”

Section: Chemical Imaging By Mev-simsmentioning

confidence: 99%

New Insights Into Structures and Composition of Plant Food Materials

Kreft¹,

Pongrac²,

Zhou³

et al. 2017

J microb biotech food sci

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The aim of this paper is to review principles and potential application of micro-proton induced X-ray emission (micro-PIXE), synchrotron-based micro-X-ray fluorescence (micro-XRF) and inductively coupled plasma-mass spectrometry (ICP-MS) hyphenated with pulsed laser ablation (LA) for analysing plants and plant materials to elucidate feature of constituensts of nutritional value. These are required in order to develop novel high-quality functional and other food products in view of the variability of properties of plant tissues and products.

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Section: Chemical Imaging By Mev-simsmentioning

confidence: 99%

New Insights Into Structures and Composition of Plant Food Materials

Kreft¹,

Pongrac²,

Zhou³

et al. 2017

J microb biotech food sci

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“…For irradiation effect, there are some detailed studies on whether analysis with ion beams lead to sample damage. To illustrate, in secondary ion mass spectrometry analysis at MeV energies (MeV-SIMS) and at low beam fluences-meaning the number of primary ions hitting the target area unit-the analysis should be nondestructive [60]. Over time, the yield of secondary molecules should also exponentially decrease as a function of beam flu- 12 ions/cm 2 is the commonly accepted static limit of MeV-SIMS corresponding to 3 hours of measurement that agrees to approximately 8% of the target surface undergoing chemical alteration due to ion-induced damage.…”

Section: Ion Beam Methods and Synchrotron-based Techniques In Hair Elmentioning

confidence: 99%

“…Recently, the technique has, however, also been tested with primary ions at MeV energies in a method termed MeV-SIMS [60,70]. A schematic overview of the technique is provided in Figure 6.…”

Section: Time-of-flight Mev Secondary Ion Mass Spectrometrymentioning

confidence: 99%

“…In MeV-SIMS, the interactions between primary ions and sample molecules are based on electronic energy loss, which creates a softer sputtering process and a 1000 times greater yield of larger and intact ionized molecules than conventional SIMS in the keV energy range. A pulse of specific primary ions at MeV energy-depending on the molecules of interest-is focused and rastered over the sample surface under ultrahigh vacuum to generate position-dependent mass spectra [60,70]. Various charged ions, also termed secondary ions, are released by the impact of the MeV primary ions with the sample surface.…”

Section: Time-of-flight Mev Secondary Ion Mass Spectrometrymentioning

confidence: 99%

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Ion Beam, Synchrotron Radiation, and Related Techniques in Biomedicine: Elemental Profiling of Hair

Cloete¹

2018

Accelerator Physics - Radiation Safety and Applications

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Elements play an imperative role in the physiological and metabolic processes of the human body. When elemental levels deviate from physiologically accepted levels due to for example poor nutrition, the body's intricate elemental and metabolic balance is disturbed. Over time, disease may develop as a result of elemental dyshomeostasis or alternatively, disease may trigger elemental dyshomeostasis as an adaptive metabolic response to an unhealthy environment. There is now a growing interest in screening human tissue to identify and quantify elemental changes as biomarkers of disease or alternatively, as outcomes of disease. The unique properties of human hair brand it the ideal substrate for the quantitative identification of elements in the body. Hair bioaccumulates elements, provides a historical overview of elemental status depending on length, and is easy and economical to sample and store. The fundamental outcome and application of hair elemental screening, however, are strongly influenced by a range of factors, including choice of analytical method. This chapter will provide a background summary of ion beam and synchrotron radiation techniques and its diverse applications for unraveling the elemental signature of hair in various fields.

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“…As a result, its use is limited to carefully selected biological problems. 44,45 One of the major limitations of SIMS is its low sensitivity to larger molecules and very high ion suppression, which prevents separating and identifying small isobaric compounds. The latter limitation has been overcome with some new advances, such as a parallel tandem MS (MS/MS) system on the TRIFT II nano-TOF 46 and fusion with the Thermo Orbitrap.…”

Section: State Of the Art In Msimentioning

confidence: 99%

Mass Spectrometry Imaging in Nanomedicine: Unraveling the Potential of MSI for the Detection of Nanoparticles in Neuroscience

Barré

Heeren

Ogrinc

2017

CPD

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Mass spectrometry imaging (MSI) can uniquely detect thousands of compounds allowing both their identification and localization within biological tissue samples. MSI is an interdisciplinary science that crosses the borders of physics, chemistry and biology, and enables local molecular analysis at a broad range of length scales: From the subcellular level to whole body tissue sections. The spatial resolution of some mass spectrometers now allows nano-scale research, crucial for studies in nanomedicine. Recent developments in MSI have enabled the optimization and localization of drug delivery with nanoparticles within the body and in specific organs such as kidney, liver and brain. Combining MSI with nanomedicine has vast potential, specifically in the treatment of neurological disorders, where effective drug delivery has been hampered by the blood-brain barrier. This review provides an introduction to MSI and its different technologies, with the application of MSI to nanomedicine and the different possibilities that MSI offers to study molecular signals in the brain. Finally, we provide an outlook for the future and exciting potential of MSI in nanoparticle-related research.

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Molecular imaging of cannabis leaf tissue with MeV-SIMS method

Cited by 20 publications

References 13 publications

New Insights Into Structures and Composition of Plant Food Materials

New Insights Into Structures and Composition of Plant Food Materials

Ion Beam, Synchrotron Radiation, and Related Techniques in Biomedicine: Elemental Profiling of Hair

Mass Spectrometry Imaging in Nanomedicine: Unraveling the Potential of MSI for the Detection of Nanoparticles in Neuroscience

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