Mass Spectrometry Imaging in Nanomedicine: Unraveling the Potential of MSI for the Detection of Nanoparticles in Neuroscience

Barré, Florian P.Y.; Heeren, Ron M. A.; Ogrinc, Nina

doi:10.2174/1381612823666170111112550

Cited by 10 publications

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References 134 publications

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“…In situ imaging techniques would be extremely helpful to better understand the dynamic interaction of NPs with biota, such as delineating the time-dependent biodistribution. While this level of analysis is possible to some extent for NPs that provide contrast for certain imaging techniques (e.g., fluorescence imaging, 4 magnetic resonance imaging (MRI), 5 computed tomography (CT), 6 single photon emission computed tomography (SPECT), 7 mass spectrometry imaging (MSI), 8 etc. ), there are clear limitations in terms of the type of NPs that can be used, in imaging specimens with macroscopic dimensions, and in the potential damage to or destruction of the sample during measurements.…”

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confidence: 99%

Size- and Ligand-Dependent Transport of Nanoparticles in Matricaria chamomilla as Demonstrated by Mass Spectroscopy and X-ray Fluorescence Imaging

Liu

Körnig

et al. 2022

ACS Nano

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Matricaria chamomilla flowers were incubated with gold nanoparticles of different sizes ranging from 1.4 to 94 nm. After different incubation times of 6, 12, 24, and 48 h, the gold distribution in the flowers was destructively measured by inductively coupled plasma mass spectrometry (ICP-MS) and non-destructively measured by X-ray fluorescence imaging (XFI) with high lateral resolution. As a control, the biodistribution of iodine ions or iodine-containing organic molecules (iohexol) was determined, in order to demonstrate the feasibility of mapping the distribution of several elements in parallel. The results show a clear size-dependent transport of the nanoparticles. In addition, the surface chemistry also plays a decisive role in disposition. Only the 1.6 nm nanoparticles coated with acetylcysteine could be efficiently transported through the stem of the flowers into the petals. In this case, almost 80% of the nanoparticles which were found within each flower were located in the petals. The study also highlights the potential of XFI for in situ recording of in vivo analyte biodistribution.

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confidence: 99%