Molecular imaging in musculoskeletal infections with 99mTc-UBI 29-41 SPECT/CT

Sathekge, Mike; García-Perez, Osvaldo; Páez, Diana; El-Haj, Noura; Kain-Godoy, Taylor; Lawal, Ismaheel; Estrada-Lobato, Enrique

doi:10.1007/s12149-017-1219-7

Cited by 24 publications

(22 citation statements)

References 15 publications

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“…Conducting research has been shown to facilitate the adoption of new techniques in small-scale initiatives [28]. Given the recent development of infection-specific radiopharmaceuticals such as 99mTc-UBI [29], advances in SPECT quantification and standardisation of imaging procedures [30], the approaches to raise awareness about NM infection imaging and its potential adoption are needed.…”

Section: Discussionmentioning

confidence: 99%

Underutilisation of nuclear medicine scans at a regional hospital in Nigeria: need for implementation research

Orunmuyi¹,

Lawal²,

Omofuma³

et al. 2020

ecancer

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Background: Nuclear medicine needs better integration into the Nigerian health system. To understand the relevant public health initiatives that will be required, this study assessed the pattern of nuclear medicine imaging services at the first nuclear medicine centre in Nigeria from January 2010 to December 2018. Methods: The data of consecutive nuclear medicine (NM) scans performed between 1st January 2010 and 31st December 2018 at the NM department in a tertiary hospital in Nigeria were extracted from patient records and analysed using SAS version 9.4 (SAS Institute, Cary, NC). The National Cancer Institute's Joinpoint software and QCIS (QGIS project) were used to estimate imaging trends and geographical spread of patients. Results: An average of 486 scans per year was performed during the study period. Patients travelled from 32 of Nigeria's 36 states, and the majority (65%) travelled more than 100 km to obtain NM scans. Bone scans accounted for 88.1% of the studies. The remainder were renal scintigraphy (7.3%), thyroid scans (2.5%), whole-body iodine scans (1.7%) and others (0.4%). Conclusions: NM in Nigeria appears underutilised. Furthermore, the studies to characterise the access gaps and implementation needs will contribute to the design of practical strategies to strengthen NM services in Nigeria.

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Section: Discussionmentioning

confidence: 99%

Underutilisation of nuclear medicine scans at a regional hospital in Nigeria: need for implementation research

Orunmuyi¹,

Lawal²,

Omofuma³

et al. 2020

ecancer

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“…While diagnosis of an infectious process is based on clinical and laboratory data, localization can be difficult. Infectionseeking tracers labelled with single-photon-emitting radionuclides include autologous leukocytes [white blood cells (WBC)] labelled with 99m Tc-hexamethylpropyleneamine oxime (HMPAO) or 111 In-oxine [127] and, to a lesser extent, radiolabelled antibiotics, antibodies [128,129], and 99m Tcubiquicidin 29-41 [130]. 67 Ga-citrate is still used in a few scenarios such as osteomyelitis (OM) of the spine or sternum [131][132][133][134].…”

Section: Infectionmentioning

confidence: 99%

Two decades of SPECT/CT – the coming of age of a technology: An updated review of literature evidence

Israel

Pellet

Biassoni

et al. 2019

Eur J Nucl Med Mol Imaging

163

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Purpose Single-photon emission computed tomography (SPECT) combined with computed tomography (CT) was introduced as a hybrid SPECT/CT imaging modality two decades ago. The main advantage of SPECT/CT is the increased specificity achieved through a more precise localization and characterization of functional findings. The improved diagnostic accuracy is also associated with greater diagnostic confidence and better inter-specialty communication. Methods This review presents a critical assessment of the relevant literature published so far on the role of SPECT/CT in a variety of clinical conditions. It also includes an update on the established evidence demonstrating both the advantages and limitations of this modality. Conclusions For the majority of applications, SPECT/CT should be a routine imaging technique, fully integrated into the clinical decision-making process, including oncology, endocrinology, orthopaedics, paediatrics, and cardiology. Large-scale prospective studies are lacking, however, on the use of SPECT/CT in certain clinical domains such as neurology and lung disorders. The review also presents data on the complementary role of SPECT/CT with other imaging modalities and a comparative analysis, where available.

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“…99m Tc-UBI 29-41 scintigraphy has an excellent diagnostic performance in the evaluation of musculoskeletal infection. The addition of CT morphologic imaging to planar and SPECT-only imaging led to an increase in diagnostic performance and an improvement in diagnostic confidence in differentiating soft tissue from bone infection, as well as a higher inter-observer agreement [26].…”

Section: Imaging Bacteria In Humansmentioning

confidence: 99%

“…Ubiquicidin (UBI) is a cationic human antimicrobial peptide fragment. However, radiolabelled UBI 29-41 is not widely used as a clinical agent due to the lack of a commercial kit approved worldwide for human studies (only available in Mexico), however, there are over 30 clinical studies performed underlying its usefulness in imaging infections [ 25 , 26 ]. Radiolabelled ciprofloxacin, after promising results in animals, when tested in humans, showed very discordant results in terms of specificity and sensibility [ 24 ].…”

Section: Imaging Bacteria In Animal Modelsmentioning

confidence: 99%

Imaging Bacteria with Radiolabelled Probes: Is It Feasible?

Artiko

Conserva

Ferro-Flores

et al. 2020

JCM

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Bacterial infections are the main cause of patient morbidity and mortality worldwide. Diagnosis can be difficult and delayed as well as the identification of the etiological pathogen, necessary for a tailored antibiotic therapy. Several non-invasive diagnostic procedures are available, all with pros and cons. Molecular nuclear medicine has highly contributed in this field by proposing several different radiopharmaceuticals (antimicrobial peptides, leukocytes, cytokines, antibiotics, sugars, etc.) but none proved to be highly specific for bacteria, although many agents in development look promising. Indeed, factors including the number and strain of bacteria, the infection site, and the host condition, may affect the specificity of the tested radiopharmaceuticals. At the Third European Congress on Infection/Inflammation Imaging, a round table discussion was dedicated to debate the pros and cons of different radiopharmaceuticals for imaging bacteria with the final goal to find a consensus on the most relevant research steps that should be fulfilled when testing a new probe, based on experience and cumulative published evidence.

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Molecular imaging in musculoskeletal infections with 99mTc-UBI 29-41 SPECT/CT

Cited by 24 publications

References 15 publications

Underutilisation of nuclear medicine scans at a regional hospital in Nigeria: need for implementation research

Underutilisation of nuclear medicine scans at a regional hospital in Nigeria: need for implementation research

Two decades of SPECT/CT – the coming of age of a technology: An updated review of literature evidence

Imaging Bacteria with Radiolabelled Probes: Is It Feasible?

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