Molecular Imaging in Early Detection of Cancer

Lin, Xin; Xie, Jin; Chen, Xiaoyuan

doi:10.1142/9789814293686_0031

Cited by 2 publications

(1 citation statement)

References 92 publications

(116 reference statements)

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“…Positron emission tomography (PET) is a powerful non-invasive imaging technique, which allows the detection of early stage tumors, in vivo brain functions like Alzheimer and Parkinson diseases, blood flow and cardiac disorders, such as coronary artery disease, receptor binding and metabolism of drugs [1,2]. PET imaging is based on the direct detection of a subpharmacological compound labeled with b-emitting radionuclides which must have high specific activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and biological distribution study of a new carbon-11 labeled porphyrin for PET imaging. Photochemical and biological characterization of the non-labeled porphyrin

Gonçalves

Simões

Abreu

et al. 2015

J. Porphyrins Phthalocyanines

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Ideal reaction conditions were found to promote the "cold" monomethylation of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin with CH 3 I, at minute time scale, in the presence of base. The photophysical characterization, cellular uptake and dark cytotoxicity of the resulting monomethylated porphyrin were appraised. Moreover, the syntheses of the corresponding labeled porphyrin, using short-lived carbon-11, prepared in the automated radiolabeling system were efficiently performed. The purification of the labeled product was achieved via preparative HPLC with high radiochemical purity and specific radioactivity. Preliminary studies on the biodistribution of 5,10,15-tris(3-hydroxyphenyl)-20-(3-[ 11 C]methoxyphenyl)porphyrin carried out in a BALB/C normal mouse, using PET imaging, showed that the liver is the main pathway for excretion.

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Section: Introductionmentioning

confidence: 99%