Tetrapyrrolic Macrocycles: Potentialities in Medical Imaging Technologies

Synthesis and biological distribution study of a new carbon-11 labeled porphyrin for PET imaging. Photochemical and biological characterization of the non-labeled porphyrin

“…So, the high affinity of tetrapyrrolic macrocycles for accumulation in tumor cells makes them promising compounds also for development of contrast agents like radiolabeled agents for cancer imaging. In this way, tetrapyrrolic macrocycles are a class of agents with upmost interest for the development of theranostic probes due to their flexibility to synthetic modulation, low dark toxicity and high biocompatibility [14][15][16][17]. The application of labeled tetrapyrrolic macrocycles as PET probes has already been described in recent literature, namely through radionuclides with long semi-disintegration periods but with lower positron emission decays, such as 64 Cu [18,19], 68 Ga [20,21], and 62 Zn [22].…”

A New Tool in the Quest for Biocompatible Phthalocyanines: Palladium Catalyzed Aminocarbonylation for Amide Substituted Phthalonitriles and Illustrative Phthalocyanines Thereof

“…Molecules of the tetrapyrrole family (e.g., porphyrin and phthalocyanine derivatives) are probably the most appealing chromophores for a vast array of photoactivated processes, such as phototherapy [1][2][3], photodiagnosis [4][5][6], photocatalysis [7,8], solar energy conversion [9,10], and also as photomaterials [11][12][13]. In particular, phthalocyanines largely fulfil a crucial optical requisite, necessary for photomedicinal applications, which is a strong absorption in near-infrared (NIR) spectral region (600-900 nm), as light in this region affords the deepest penetration in soft tissue.…”

Halogenated meso-phenyl Mn(III) porphyrins as highly efficient catalysts for the synthesis of polycarbonates and cyclic carbonates using carbon dioxide and epoxides

“…Halides, quaternary salts and ionic liquids are known to produce preferentially cyclic carbonates, which are the most stable thermodynamic products [9], while metal complexes can catalyze the formation of polymers and/or cyclic carbonate products, depending from the co-catalyst, substrate and reaction conditions [9]. It should be mentioned that most of the metal based complexes, of which tetrapyrrolic macrocycles are privileged compounds for many applications [13,14,15,16,17,18,19,20,21], require the presence of a co-catalyst, acting as nucleophile, whether added to the reaction (binary catalytic systems) [22,23,24,25] or already included in the structure of the complex (bifunctional catalytic systems) [26].…”