Molecular identification of emergent GII.P17-GII.17 norovirus genotype, Romania, 2015

Dinu, Sorin; Nagy, Mariana; Negru, Dana; Popovici, Emilian Damian; Zota, Lavinia; Oprişan, Gabriela

doi:10.2807/1560-7917.es.2016.21.7.30141

Cited by 31 publications

(14 citation statements)

References 16 publications

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“…According to global trends, it was expected that HuNoV GII.17 would be detected more consistently than GII.4 in Korea. While HuNoV GII.17 was detected during 2013−2014, similar to the results for China, the US and Europe, HuNoV GII.4 was detected in 2015 [13][14][15][16][17], and was also detected along with HuNoV GII.17 in 2016 (Table 2 and Fig. 2).…”

supporting

confidence: 58%

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Prevalence of Human Norovirus by Genotype in Contaminated Groundwater in Korea Over the Last Decade (2007-2016)

Lee¹,

Park²,

Kim³

et al. 2017

Preprint

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This study investigated the presence of human Norovirus (HuNoV) by genotype in 1,486 groundwater samples, collected from 843 groundwater wells suspected of contamination during 2007−2016, in Republic of Korea. We identified and genotyped 186 HuNoV sequences in 178HuNoV-positive samples using the RIVM-NoroNet norovirus genotyping tool (NGT) and phylogenetic tree analysis based on RIVM-NoroNet reference sequences. HuNoV GII was more prevalent than GI. The major genotypes detected were HuNoV GII.4 (43.0%), GII.22 (15.6%), GI.5 (10.2%) and GI.1 (8.6%); 14 genotypes accounted for < 5.0%. Increasing HuNoV Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 5

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supporting

confidence: 58%

“…One sample contained both GI.3 and GI.7, and both were included in the overall count (Table 2) HuNoV GI and GII genotypes (GII. 2,5,7,9,11,12,14,15,16,18,19,20, and 21) were not found ( Table 2). …”

mentioning

confidence: 94%

Prevalence of Human Norovirus by Genotype in Contaminated Groundwater in Korea Over the Last Decade (2007-2016)

Lee¹,

Park²,

Kim³

et al. 2017

Preprint

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“…Secondly, in the last phase, other, novel GII.P17-GII.17 viruses have replaced the previously dominant GII.4 in China since 2014 [ 51 ]. The novel GII.17 is also the predominant genotype in other countries [ 52 , 53 ], while in Japan, a sharp increase in the number of cases caused by this novel virus has been observed during 2014–2015 [ 54 ]. However, in 2015, its genetic diversity, adaptation and fitness were also found in China, especially in high incidence areas.…”

Section: Discussionmentioning

confidence: 99%

Genotypic and Epidemiological Trends of Acute Gastroenteritis Associated with Noroviruses in China from 2006 to 2016

Qin

Chan

Cai

et al. 2017

IJERPH

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There are periodical norovirus-associated acute gastroenteritis outbreaks around the world. This study aimed to analyze the molecular and epidemiological features of norovirus infections in China during 2006–2016. We extracted epidemiological data from 132 norovirus outbreaks and the norovirus genotyping for 1291 sequences in China over the past ten years. A total of 132 norovirus outbreaks (8133 cases) were reported in China, where the east and south regions were most affected [47.7% (63/132)]. The highest number of outbreaks occurred in 2015. A seasonal pattern has been observed, with a peak from November to the following March. Most of the outbreaks occurred in middle and primary schools, accounting for 28.8% (38/132), and 28.0% (37/132) of outbreaks, respectively. The dominant age group was 10 to 19 years old, responsible for 75.7% (933/1232) of cases. Generally, the dominant genotypes was GII, for 81.9% (1058/1291) of sequences. G II.4 was the predominant genotype in China from 2004 to 2014. However, the GII.17 became more prevalent starting in 2014. Norovirus-associated acute gastroenteritis increased sharply in recent years caused by the emergence of GII.17, but epidemiological features have not changed during 2006–2016. Vigilant surveillance should be strengthened to promptly detect any variation.

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“…A newly emerging HuNoV GII.17 isolate, first identified in China, seems to be outcompeting the HuNoV GII.4 in some parts of Asia, resulting in increased outbreaks since the winter season of 2014 to 2015 ( 22 ). Recent studies suggest that this novel variant may be spreading globally, which could lead to the replacement of the pandemic genotype GII.4 by GII.17 ( 22 – 26 ). Fitting with the hypothesis that fidelity is linked to rapid emergence of norovirus isolates, the GII.17 isolate displays evolutionary rates at least 1 order of magnitude higher than those seen with GII.4 ( 25 ).…”

Section: Introductionmentioning

confidence: 99%

Norovirus Polymerase Fidelity Contributes to Viral Transmission In Vivo

Arias

Thorne

Ghurburrun

et al. 2016

mSphere

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Virus replication fidelity and hence the intrahost genetic diversity of viral populations are known to be intricately linked to viral pathogenesis and tropism as well as to immune and antiviral escape during infection. In this study, we investigated whether changes in replication fidelity can impact the ability of a virus to transmit between susceptible hosts by the use of a mouse model for norovirus. We show that a variant encoding a high-fidelity polymerase is transmitted less efficiently between mice than the wild-type strain. This constitutes the first experimental demonstration that the polymerase fidelity of viruses can impact transmission of infection in their natural hosts. These results provide further insight into potential reasons for the global emergence of pandemic human noroviruses that display alterations in the replication fidelity of their polymerases compared to nonpandemic strains.

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Molecular identification of emergent GII.P17-GII.17 norovirus genotype, Romania, 2015

Cited by 31 publications

References 16 publications

Prevalence of Human Norovirus by Genotype in Contaminated Groundwater in Korea Over the Last Decade (2007-2016)

Prevalence of Human Norovirus by Genotype in Contaminated Groundwater in Korea Over the Last Decade (2007-2016)

Genotypic and Epidemiological Trends of Acute Gastroenteritis Associated with Noroviruses in China from 2006 to 2016

Norovirus Polymerase Fidelity Contributes to Viral Transmission In Vivo

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