Molecular Identification of a Human Carcinoma‐associated Glycoprotein Antigen Recognized by Mouse Monoclonal Antibody FU‐MK‐1

Tomita, Yoshihiro; Yamamoto, Takafumi; Kuwahara, Maki; Watanabe, Ryoji; Iwasaki, Hiroshi; Kikuchi, Masahiro; Kuroki, Masahide

doi:10.1111/j.1349-7006.2000.tb00936.x

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…We examined the expression of MK-1 in 81 patients. MK-1 expression was demonstrated in 43.2% of the patients; this finding was in agreement with the results of Tomita et al (7), who reported MK-1 expression in 2 of 5 bladder carcinomas. Some of the MK-1-positive cases exhibited heterogeneity in MK-1 immunoreactivity with regard to the number of stained cells and the intensity of staining.…”

Section: Discussionsupporting

confidence: 92%

“…Because it is overexpressed in most carcinomas, MK-1 has been used as a target for the diagnosis and therapy of cancer (3). Only a few papers, however, have described the expression and distribution of MK-1 in urological cancers (7). In the present study, in order to investigate whether MK-1 can be used as a prognostic marker in SCC of the bladder, we examined the expression of MK-1 in 81 cases of bladder SCC associated with bilharziasis.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic value of Carcinoma-associated Antigen MK-1 in Urinary Bladder Carcinoma

et al. 2006

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Background The present study has been performed to evaluate the expression of MK-1 in schistosomiasis-associated squamous cell carcinoma of the urinary bladder and to correlate this new marker with the conventional histopathological parameters. Patients and methods Paraffin sections of 5-μm thickness from 81 cases were prepared for hematoxylin and eosin staining and immunohistochemical analysis of MK-1 expression was carried out. Results Forty-six cases (56.8%) were positive for MK-1 protein expression. Significant correlations between MK-1 expression and tumor grade (p=0.004), schistosoma (p=0.031), DNA ploidy (p=0.001), and tumor recurrence (p<0.001) were observed. MK-1, sex, tumor grade, stage, schistosoma, DNA ploidy, and recurrence were evaluated in relation to outcome. Univariate and multivariate analysis of survival were performed. The overall 5-year survival was 51.85%. In univariate analysis, MK-1 expression, tumor grade, DNA ploidy, and recurrence had a significant impact on the survival of these patients. In a Cox proportional hazards model, recurrence maintained its significant impact on survival. Conclusions These findings suggest that MK-1 is a prognostic marker for recurrence: 34 (87.2%) of 39 recurrent cases were positive for MK-1 expression. However, only recurrence was an independent prognostic factor in patients with schistosomiasis-associated squamous cell carcinoma of the bladder.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Prognostic value of Carcinoma-associated Antigen MK-1 in Urinary Bladder Carcinoma

et al. 2006

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“…Watanabe et al [13] obtained it from the carcinoma cells of a poorly differentiated gastric adenocarcinoma. Tomita et al [14] found that MK-1, the target molecule of FU-MK-1, is encoded by the GA733-2 gene, which is currently being used as a target in clinical trials with monoclonal antibodies.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of p53 protein and MK-1 (a tumor-associated antigen) expression in gastric carcinoma

Deveci̇

Deveci

2007

Gastric Cancer

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Preparation of recombinant MK-1/Ep-CAM and establishment of an ELISA system for determining soluble MK-1/Ep-CAM levels in sera of cancer patients

Abe

Imakiire

Yamauchi

et al. 2002

Journal of Immunological Methods

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Molecular Identification of a Human Carcinoma‐associated Glycoprotein Antigen Recognized by Mouse Monoclonal Antibody FU‐MK‐1

Cited by 6 publications

References 31 publications

Prognostic value of Carcinoma-associated Antigen MK-1 in Urinary Bladder Carcinoma

Prognostic value of Carcinoma-associated Antigen MK-1 in Urinary Bladder Carcinoma

Prognostic value of p53 protein and MK-1 (a tumor-associated antigen) expression in gastric carcinoma

Preparation of recombinant MK-1/Ep-CAM and establishment of an ELISA system for determining soluble MK-1/Ep-CAM levels in sera of cancer patients

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