Prognostic value of p53 protein and MK-1 (a tumor-associated antigen) expression in gastric carcinoma

Deveci̇, Mustafa; Deveci, Güzin

doi:10.1007/s10120-007-0418-7

Cited by 15 publications

(12 citation statements)

References 19 publications

(48 reference statements)

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“…In gastric carcinomas, MK-1 is more frequently expressed in cardiac tumors (with 50% expression rate), in large (> 3 cm) tumors, and in specimens from patients with more than five metastatic lymph nodes [2]. In urinary bladder carcinoma, 56.8% were positive for MK-1 protein expression and significant correlations were observed between MK-1 expression and tumor grade, schistosoma, DNA ploidy and tumor recurrence [3].…”

Section: Discussionmentioning

confidence: 99%

Subtype distribution of lymphomas in Southwest China: Analysis of 6,382 cases using WHO classification in a single institution

et al. 2011

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BackgroundThe subtype distribution of lymphoid neoplasms in Southwest China was analyzed according to WHO classifications. This study aims to analyze subtype distribution of lymphomas in southwest China.MethodsLymphoid neoplasms diagnosed within 9 years in a single institution in Southwest China were analyzed according to the WHO classification.ResultsFrom January 2000 to December 2008, a total number of 6,382 patients with lymphoma were established, of which mature B-cell neoplasms accounted for 56%, mature T- and NK-cell neoplasms occupied 26%, and precursor lymphoid neoplasms and Hodgkin lymphomas were 5% and 13%, respectively. Mixed cellularity (76%) was the major subtype of classical Hodgkin lymphoma; and the bimodal age distribution was not observed. The top six subtypes of non-Hodgkin lymphoma were as follows: diffuse large B-cell lymphoma, extranodal NK/T-cell lymphoma, nasal type, extranodal marginal zone lymphoma of mucosa associated lymphoid tissue, follicular lymphoma, precursor lymphoid neoplasms, and chronic lymphocytic leukemia/small lymphocytic lymphoma. Extranodal lymphomas comprised about half of all cases, and most frequently involved Waldeyer's ring, gastrointestinal tract, sinonasal region and skin.ConclusionsThe lymphoid neoplasms of Southwest China displayed some epidemiologic features similar to those reported in literature from western and Asian countries, as well as other regions of China, whereas some subtypes showed distinct features. The high frequency of mature T/NK cell neoplasms and extranodal lymphomas, especially for extranodal NK/T-cell lymphoma, nasal type, is the most outstanding characteristic of this series.

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Section: Discussionmentioning

confidence: 99%

Subtype distribution of lymphomas in Southwest China: Analysis of 6,382 cases using WHO classification in a single institution

et al. 2011

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“…10 In GC patients, the clinicopathologic characteristics and prognostic roles of MSI and p53 expression have been reported in several studies. 11 – 15 However, considering of the majority of HPIP-GC in GC patients, the results of the previous reports could represent the role of MSI and p53 expression in HPIP-GC. To our knowledge, there is no study evaluating the molecular prognostic markers such as MSI and p53 expression, confined to HPIN-GC.…”

Section: Introductionmentioning

confidence: 94%

Helicobacter pylori and Molecular Markers as Prognostic Indicators for Gastric Cancer in Korea

et al. 2014

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Background: The prognosis of H. pylori infection-negative gastric cancer (HPIN-GC) has been rarely investigated. Applying a strict definition of H. pylori status, the prognosis and molecular prognostic markers in HPIN-GC were evaluated. Methods: A combination of multiple methods was carried out to strictly evaluate H. pylori infection in gastric cancer (GC) patients between June 2003 and October 2012 at Seoul National University Bundang Hospital. H. pylori infection was defined as negative if histology, a rapid urease test, culturing, serology and history of H. pylori eradication were all negative. Patients with severe gastric atrophy by the serum pepsinogen test or histology were assumed to have had a previous H. pylori infection. Epstein-Barr virus (EBV) in situ hybridization, PCR-based microsatellite instability (MSI) testing, and p53 immunohistochemistry were performed. Results: Compared to 509 H. pylori infection-positive gastric cancer (HPIN-PC) patients, 24 HPIN-GC patients showed a significantly higher frequency of cardia location (P=0.013), and the depth of invasion in HPIN-GC was more advanced, although there was no statistical significance (pT3-pT4, 37.5% for HPIN-GC vs. 28.5% for HPIP-GC, P=0.341). In multivariate analysis, depth of invasion and lymph node metastasis were identified as the most important prognostic factors for relapse-free survival and overall survival (P＜0.001). However, the status of H. pylori infection was not an independent prognostic factor for relapse-free survival and overall survival. The positivity of EBV in both groups was low, and the survivals according to MSI and p53 status in HPIN-GC patients were not significantly different. Conclusions:The status of H. pylori infection was not a prognostic factor for survival in GC patients when applying the strict definition of H. pylori infection. The prognostic implication of MSI and p53 on survival in HPIN-GC patients was not clear. (J Cancer Prev 2014;19:56 -67)

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“…Much effort has been made for a long time to identify prognostic biomarkers in gastric cancer patients. Although genes associated with metastasis ( e.g., MMP9), growth ( e.g., EGF), apoptosis ( e.g., p53) and angiogenesis ( e.g., VEGF) have been investigated in recent studies, to identify an established marker possessing the predicative value for survival of gastric cancer patients remains a topic that needs to be explored 3–6. E‐cadherin is the prototype of the cadherin family that links to catenins to form E‐cadherin/catenin complex which is further linked to the actin cytoskeleton 7.…”

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confidence: 99%

The prognostic value of E‐cadherin in gastric cancer: A meta‐analysis

Xing

Tang

Yuan

et al. 2012

Intl Journal of Cancer

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The prognostic impact of E-cadherin downregulation in gastric cancer has been assessed for years while the results are controversial and heterogeneous. We thus comprehensively reviewed the evidence for evaluation of E-cadherin expression in gastric cancer to determine this effect. We searched PubMed and Embase to identify eligible studies, and 26 studies comprising 4,383 gastric cancer patients were included to assess the association between E-cadherin immunohistochemical expression and overall survival (OS) and clinicopathological characteristics. Summary hazard ratios (HRs) or odds ratios (ORs) with 95% confidence interval (95% CI) were calculated to estimate the effect. We also performed meta-regression and subgroup analysis according to study location, publication year, number of patients, quality score of studies and cut-off value. Reduced E-cadherin expression was significantly correlated with poor OS of gastric cancer patients (HR 1.62, 95% CI 1.34-1.96). Subgroup analysis indicated that E-cadherin low-expression had an unfavorable impact on OS in Asian patients (HR 1.87, 95% CI 1.45-2.41). Moreover, downregulation of E-cadherin was significantly associated with TNM stage (OR 2.52, 95% CI 1.85-3.43), the depth of invasion (OR 2.01, 95% CI 1.39-2.90), lymph node metastasis (OR 2.39, 95% CI 1.68-3.40), distant metastasis (OR 2.23, 95% CI 1.21-4.11), grade of differentiation (OR 2.26, 95% CI 1.60-3.21), vascular invasion (OR 1.86, 95% CI 1.10-3.13) and histological type of gastric cancer (OR 4.22, 95% CI 2.96-6.02). This meta-analysis revealed that E-cadherin expression might be a predicative factor of poor prognosis for gastric cancer particularly in Asia.Despite the recent reduction in incidence, gastric cancer is still the second most frequent cause of cancer-related death worldwide, leading to 738,000 deaths worldwide in 2008. Much effort has been made for a long time to identify prognostic biomarkers in gastric cancer patients. Although genes associated with metastasis (e.g., MMP9), growth (e.g., EGF), apoptosis (e.g., p53) and angiogenesis (e.g., VEGF) have been investigated in recent studies, to identify an established marker possessing the predicative value for survival of gastric cancer patients remains a topic that needs to be explored.3-6 E-cadherin is the prototype of the cadherin family that links to catenins to form E-cadherin/catenin complex which is further linked to the actin cytoskeleton.7 Recent studies have shown that E-cadherin not only acts in infiltration and metastasis, but also has an important role of tumorsuppressor in numerous cancers comprising gastric cancer, providing the evidence that E-cadherin plays a vital role in the development and progression of gastric cancer and might be significantly associated with the prognosis of patients. 8,9 Low or absent E-cadherin expression, implicated in the pathogenesis of gastric cancer, was caused by several molecular mechanisms. Promoter hypermethylation is an import mechanism silencing tumor suppressors and has been found to be significa...

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Prognostic value of p53 protein and MK-1 (a tumor-associated antigen) expression in gastric carcinoma

Cited by 15 publications

References 19 publications

Subtype distribution of lymphomas in Southwest China: Analysis of 6,382 cases using WHO classification in a single institution

Subtype distribution of lymphomas in Southwest China: Analysis of 6,382 cases using WHO classification in a single institution

Helicobacter pylori and Molecular Markers as Prognostic Indicators for Gastric Cancer in Korea

The prognostic value of E‐cadherin in gastric cancer: A meta‐analysis

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