Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease

Fu, Yuan; Ito, Mikako; Fujita, Yasunori; Ito, Masafumi; Ichihara, Masatoshi; Matsubara, Akio; Suzuki, Yumi; Maesawa, Satoshi; Kajita, Yasukazu; Hirayama, Masaaki; Ohsawa, Ikuroh; Ohta, Shigeo; Ohno, Kinji

doi:10.1016/j.neulet.2009.02.016

Cited by 189 publications

(131 citation statements)

References 38 publications

Supporting

Mentioning

124

Contrasting

Unclassified

Order By: Relevance

“…At present, H 2 and hydrogen-rich saline (HS) have been certified as providing protection against many kinds of illnesses, including ischemia-reperfusion injury (Huang et al, 2011), sepsis (Xie et al, 2010a), multiple organ dysfunction syndrome (Xie et al, 2010b), type II diabetes mellitus (Kajiyama et al, 2008), and neurodegenerative disorders (Fu et al, 2009). Furthermore, our previous tests have shown that H 2 can provide protection for mice with sepsis and suppress apoptosis , while its effects on the integrity of junctions between endothelial cells require further research.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin

Yu¹,

Wang²,

Han³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT.We observed the effect of hydrogen-rich medium on lipopolysaccharide (LPS)-induced human umbilical vein endothelial cells (HUVECs), hyaline leukocyte conglutination, and permeability of the endothelium. Endotheliocytes were inoculated on 6-well plates and randomly divided into 4 groups: control, H 2 , LPS, LPS+H 2 , H 2 , and LPS+H 2 in saturated hydrogen-rich medium. We applied Wright's staining to observe conglutination of hyaline leukocytes and HUVECs, flow cytometry to determine the content of vascular cell adhesion protein 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1), enzymelinked immunosorbent assay to measure the E-selectin concentration in the cell liquor, the transendothelial electrical resistance (TEER) to test the permeability of endothelial cells, and Western blot and im- munofluorescence to test the expression and distribution of vascular endothelial (VE)-cadherin. Compared with control cells, there was an increase in endothelium-hyaline leukocyte conglutination, a reduction in VCAM-1, ICAM-1, and E-selectin, and the TEER value increased obviously. Compared with LPS, there was an obvious reduction in the conglutination of LPS+H 2 cells, a reduction in VCAM-1, ICAM-1, and E-selectin levels, and a reduction in the TEER-resistance value, while the expression of VE-cadherin increased. Fluorescence results showed that, compared with control cells, the VE-cadherin in LPS cells was incomplete at the cell joints. Compared with LPS cells, the VE-cadherin in LPS+H 2 cells was even and complete at the cell joints. Liquid rich in hydrogen could reduce LPS-induced production of adhesion molecules and endothelium-hyaline leukocyte conglutination, and influence the expression and distribution of VE-cadherin to regulate the permeability of the endothelium.

show abstract

Section: Introductionmentioning

confidence: 99%

Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin

Yu¹,

Wang²,

Han³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…It has been demonstrated that H 2 exerted preventive or therapeutic effects on cerebral, myocardial and hepatic ischemia-reperfusion injuries, intestinal, lung, renal and heart transplantation, and acute graft-versus-host disease post-allogeneic hematopoietic stem cell transplantation (20,21). Recent basic and clinical research revealed that hydrogen is an important physiological regulatory factor with antioxidant, anti-inflammatory and anti-apoptotic protective effects on cells and organs (22)(23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy

Qing-xi

Pan

et al. 2017

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Abstract. The present study was conducted to investigate the protective effect of hydrogen-rich water on the liver function of colorectal cancer (CRC) patients treated with mFOLFOX6 chemotherapy. A controlled, randomized, single-blind clinical trial was designed. A total of 152 patients with CRC were recruited by the Department of Oncology of Taishan Hospital (Taian, China) between June 2010 and February 2016, among whom 146 met the inclusion criteria. Subsequently, 144 patients were randomized into the treatment (n=80) and placebo (n=64) groups. At the end of the study, 76 patients in the hydrogen treatment group and 60 patients in the placebo group were included in the final analysis. The changes in liver function after the chemotherapy, such as altered levels of alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase, indirect bilirubin (IBIL) and direct bilirubin, were observed. The damaging effects of the mFOLFOX6 chemotherapy on liver function were mainly represented by increased ALT, AST and IBIL levels. The hydrogen-rich water group exhibited no significant differences in liver function before and after treatment, whereas the placebo group exhibited significantly elevated levels of ALT, AST and IBIL. Thus, hydrogen-rich water appeared to alleviate the mFOLFOX6-related liver injury.

show abstract

“…Up to now, hydrogen-rich water has proven to be effective for various disease models, including atherosclerosis , nephrotoxicity induced by an anti-cancer drug cisplatin (Nakashima-Kamimura et al, 2009), Parkinson's disease (Fu et al, 2009), colon inflammation ) and cognitive impairment (Gu et al, 2010). It is detected that H 2 can be dissolved in water up to 0.8 mM under atmospheric pressure at room temperature (Ohta, 2011).…”

Section: Oral Intake Of Hydrogen-rich Watermentioning

confidence: 99%

Hydrogen: From a Biologically Inert Gas to a Unique Antioxidant

Liu¹,

Sun²,

Tao³

2012

Oxidative Stress - Molecular Mechanisms and Biological Effects

View full text Add to dashboard Cite

Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease

Cited by 189 publications

References 38 publications

Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin

Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin

Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy

Hydrogen: From a Biologically Inert Gas to a Unique Antioxidant

Contact Info

Product

Resources

About