Molecular Genetics and Epidemiology of Prostate Carcinoma

Ruijter, Emiel; Kaa, Christina van de; Miller, Gary J.; Ruiter, Dirk J.; Debruyne, F.M.J.; Schalken, Jack A.

doi:10.1210/edrv.20.1.0356

Cited by 141 publications

(94 citation statements)

References 201 publications

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“…More reliable estimates for AR mutation is anticipated when non-neoplastic tissue is carefully removed from the sample by microdissection. 28 Androgen receptors contain N-terminal, DNA-and steroid-binding domains which are important for androgen action. Amino acid alterations in the ligand-binding domain of the AR have been described previously in hormone refractory prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

Expression and somatic mutation on androgen receptor gene in prostate cancer

et al. 2002

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Background : Lack of androgen receptor (AR) expression or mutation on the AR gene creates the tendency for androgen independence and progression of prostate cancer. However, the association between the progression and AR expression or mutations is still controversial. In this study, we evaluated the prognostic significance of AR expression and mutations in prostate cancers. Methods : Forty-two prostate adenocarcinomas and three lymph node metastatic lesions sampled prior to hormonal therapy were included in this study; AR expression was analyzed immunohistochemically using an antibody against AR and the result was scored as the percentage of AR-positive tumor cells in the total tumor cells. Polymerase chain reaction-single-strand conformational polymorphism (PCR-SSCP) analysis and DNA sequencing were used to detect AR mutations. Results : Our study revealed the average AR expression in the prostate adenocarcinoma was 52.2 ± 27.1%, which was significantly lower than that in the adjacent non-tumorous prostate tissue (68.3 ± 18.3% in average) ( P < 0.001). A significant correlation was obtained between progressionfree survival and AR expression ( P < 0.01). By SSCP analysis, three silent mutations (T649T, E709E and E711E) were detected in three separate prostate carcinomas. Conclusion : We conclude that AR expression is a useful prognostic indicator for tumor progression. Androgen receptor mutation may be an uncommon molecular event in untreated prostate cancer in Japanese men.

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Section: Discussionmentioning

confidence: 99%

Expression and somatic mutation on androgen receptor gene in prostate cancer

et al. 2002

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“…1,25(OH)2D, therefore, plays an important role in the growth and function of the normal prostate, as well as in prostate carcinogenesis. 10 The reason is that most of the actions of vitamin D are mediated through an intracellular receptor in the prostate that has a much higher affinity for 1,25(OH)2D than for other metabolites. In addition to the antiproliferative action of 1,25(OH)2D, it can cause apoptosis, 39 induce differentiation, 83 inhibit telomerase expression, 84 inhibit tumor cell invasiveness 45 and suppress tumor-induced angiogenesis.…”

Section: Hypovitaminosis Dmentioning

confidence: 99%

“…5 Prostate cancer is the second leading cause of cancer death among US men after lung cancer. 6,10 Similar to most other cancer types, prostate cancer epidemiology is not fully known. The available information does not completely explain the causation and pathogenesis of the disease.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and prostate cancer risk: a review of the epidemiological literature

Gupta

Lammersfeld

Trukova

et al. 2009

Prostate Cancer Prostatic Dis

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Prostate cancer is the most commonly diagnosed cancer in the United States. Prostate cells contain vitamin D receptors as well as enzymes necessary for vitamin D metabolism. Vitamin D metabolites have an antiproliferative and a pro-differentiating effect on prostate cancer cell lines in vitro and in vivo. As a result, there has been an emerging interest in the potential role of vitamin D in the etiology of prostate cancer. This review summarizes all available epidemiological literature on the association between dietary vitamin D, circulating levels of vitamin D and sunlight exposure in relation to prostate cancer risk. To place these studies in context, we also provide some background information on vitamin D, such as its dietary sources, metabolism, optimal levels, hypovitaminosis and relationship with the prostate.

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“…The role of testosterone in regulating the growth and differentiation of prostate cells is still unclear. Although testosterone is an essential factor for prostate gland development, it is not clear whether testosterone is a direct mitogen for prostate acinar cells (Griffiths et al, 1997;Lee et al, 1997;Lin et al, 1998;Ruijter et al, 1999).…”

Section: P Rostate Cancer Is the Most Common Cancer Inmentioning

confidence: 99%

Variations of Proline-Rich Kinase Pyk2 Expression Correlate with Prostate Cancer Progression

Stanzione

Picascia

Chieffi

et al. 2001

Laboratory Investigation

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SUMMARY:Proline-rich kinase 2 (Pyk2), also known as CAK␤ (cell adhesion kinase ␤), is a cytoplasmic tyrosine kinase that is structurally related to focal adhesion kinase. Pyk2 is expressed in different cell types including brain cells, fibroblasts, platelets, and other hemopoietic cells. Pyk2 is rapidly tyrosine phosphorylated in response to diverse extracellular signals acting via different post receptor pathways. We have investigated whether this protein kinase is functionally expressed in normal and neoplastic prostate tissues. In this study, we demonstrate that Pyk2 is expressed only in normal epithelial prostate tissue and in benign prostatic hyperplasia, whereas its expression progressively declines with an increasing grade of malignancy of prostate cancer. (Lab Invest 2001, 81:51-59).

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Molecular Genetics and Epidemiology of Prostate Carcinoma

Cited by 141 publications

References 201 publications

Expression and somatic mutation on androgen receptor gene in prostate cancer

Expression and somatic mutation on androgen receptor gene in prostate cancer

Vitamin D and prostate cancer risk: a review of the epidemiological literature

Variations of Proline-Rich Kinase Pyk2 Expression Correlate with Prostate Cancer Progression

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