Molecular genetic basis of antimicrobial agent resistance inMycobacterium tuberculosis: 1998 update

Ramaswamy, Srinivas V.; Musser, James M.

doi:10.1054/tuld.1998.0002

Cited by 969 publications

(1,072 citation statements)

References 260 publications

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“…This is consistent with the observation that unusually high proportion of Ser315Thr mutation is characteristic of INH-resistant strains in Russia [31][32][33]. As previously reported, mutations in codons 531, 526 and 516 of rpoB are responsible for 86-100% of RIF-resistant TB cases in Russia in agreement with other global reports originating from regions with high rates of MDR-TB [34]. This was also seen in Murmansk, where mutations in codon rpoB531 accounted for 91.2 % (n=104) of the RIF resistance among the primary MDR isolates.…”

Section: Discussionsupporting

confidence: 92%

Extremely high prevalence of multidrug resistant tuberculosis in Murmansk, Russia: a population-based study

Mäkinen¹,

Marjamäki²,

Haanperä-Heikkinen³

et al. 2011

Eur J Clin Microbiol Infect Dis

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Section: Discussionsupporting

confidence: 92%

Extremely high prevalence of multidrug resistant tuberculosis in Murmansk, Russia: a population-based study

Mäkinen¹,

Marjamäki²,

Haanperä-Heikkinen³

et al. 2011

Eur J Clin Microbiol Infect Dis

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“…Foram encontradas mutações em múltiplos códons que resultaram em dois, três ou quatro aminoácidos diferentes na proteína EmbB. 28 Para a total compreensão dos mecanismos utilizados pela micobactéria para aquisição de resistência ao EMB, ainda se faz necessária a identificação de outros locais ou mutações que podem ocorrer nesses organismos resistentes, possibilitando estudos bioquímicos e de variantes moleculares envolvidas nesse processo.…”

Section: Resistência Ao Etambutolunclassified

Tuberculose resistente: revisão molecular

et al. 2002

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ResumoO progresso na compreensão dos mecanismos de resistência aos fármacos usados no tratamento da tuberculose tem permitido o desenvolvimento de novos métodos para a detecção da tuberculose resistente. A resistente aos fármacos representa uma ameaça para os programas de controle da tuberculose. Para tanto, é necessário conhecer o padrão de sensibilidade das linhagens para fornecer o tratamento adequado. Os estudos moleculares dos mecanismos de ação dos fármacos antituberculose têm elucidado as bases genéticas da resistência aos fármacos em Mycobacterium tuberculosis. Os mecanismos de resistência aos fármacos na tuberculose são causados por mutações cromossomais em diferentes genes da bactéria. Durante a exposição aos fármacos, há uma pressão seletiva favorecendo o desenvolvimento de linhagens resistentes. A tuberculose multirresistente é um problema nacional e internacional que traz sérias dificuldades para o controle global da doença. Realizou-se uma revisão sobre os mecanismos moleculares associados à resistência aos fármacos com ênfase nas novas perspectivas para detectar os isolados resistentes. AbstractProgress to understanding the basis of resistance to antituberculous drugs has allowed molecular tests for detection of drug-resistant tuberculosis to be developed. Drug-resistant tuberculosis poses a threat to tuberculosis control programs. It is necessary thus to know drug susceptibilities of individual patient's strain to provide the appropriate drug combinations. Molecular studies on the mechanism of action of antituberculous drugs have elucidated the genetic basis of drug resistance in M. tuberculosis. The mechanisms of drug resistance in tuberculosis are a result of chromosomal mutations in different genes of the bacteria. Upon drug exposure there is a selective pressure for such resistant mutants. Multidrug-resistant tuberculosis is a health problem of increasing significance for the whole global community. This paper reviews the molecular mechanisms associated with drugresistance as well the new perspectives for detecting resistant isolates. Current Comments Atualização

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“…The above mentioned serious concerns has leads to the development of new anti-tubercular drugs. The internal resistance of M.tuberculosis is due to several factors such as active drug efflux mechanism, highly permeable mycolic acid containing cell wall and the production of drug modifying and drug inactivating enzymes (Ramaswamy S, et al, 1998). M.tuberculosis contains unique signature fatty acids and mycolic acids that are unusually long chain α-alkyl and β-hydroxy fatty acids of 60-90 carbons (Takayama K, et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…The replacement of an amino acid in the NADH binding site of InhA apparently results in INH resistance, preventing the inhibition of mycolic acid biosynthesis (Zhang YM, et al, 2006). Various genetic mutations have been observed to occur usually between codons 138 and 328 (Ramaswamy S, et al, 1998). The Ser-315-Thr mutation is most frequent and found in about 40% of all INH-resistant strains (Marttila HJ, et al, 1998, Zhang YM, et al, 2006.…”

mentioning

confidence: 99%

Insilico Analysis of Phytoconstituents from Allium sativum as Potential Inhibitors of Inha in Mycobacterium tuberculosis

Kannan

Alharbi

Kadaikunnan

et al. 2016

Braz. arch. biol. technol.

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Molecular genetic basis of antimicrobial agent resistance inMycobacterium tuberculosis: 1998 update

Cited by 969 publications

References 260 publications

Extremely high prevalence of multidrug resistant tuberculosis in Murmansk, Russia: a population-based study

Extremely high prevalence of multidrug resistant tuberculosis in Murmansk, Russia: a population-based study

Tuberculose resistente: revisão molecular

Insilico Analysis of Phytoconstituents from Allium sativum as Potential Inhibitors of Inha in Mycobacterium tuberculosis

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