Molecular Genetic Alterations and Clinical Features in Early-Onset Colorectal Carcinomas and Their Role for the Recognition of Hereditary Cancer Syndromes

Losi, Lorena; Gregorio, Carmela Di; Pedroni, Monica; Ponti, Giovanni; Roncucci, Luca; Scarselli, A; Genuardi, Maurizio; Baglioni, Silvana; Marino, Massimiliano; Rossi, Giuseppina; Benatti, Piero; Maffei, Stefania; Menigatti, Mirco; Roncari, Barbara; Leòn, Maurizio Ponz de

doi:10.1111/j.1572-0241.2005.00223.x

Cited by 64 publications

(50 citation statements)

References 40 publications

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“…Our results showed that the immunohistochemical analysis of MMR proteins and confirmation by using four monomorphic markers (BAT25, BAT26, NR21, and CAT25) revealed a rate of 15% instability (10/70 (18). Whatever the origin of this MSI, testing for MSI is important.…”

Section: Discussionmentioning

confidence: 98%

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Clinical and molecular characterization of colorectal cancer in young Moroccan patients

Benmoussa¹,

Badre²,

Pedroni³

et al. 2012

Turk J Gastroenterol

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Section: Discussionmentioning

confidence: 98%

“…The MSI status was evaluated using 4 mononucleotide markers (BAT25, BAT26, NR24 and CAT25) (13). Using this panel of monomorphic markers, a tumor was defined as MSI-positive when at least 2 markers showed instability.…”

Section: Microsatellites Analysismentioning

confidence: 99%

Clinical and molecular characterization of colorectal cancer in young Moroccan patients

Benmoussa¹,

Badre²,

Pedroni³

et al. 2012

Turk J Gastroenterol

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“…In comparison to elder CRC, EOCRC cases have some distinguishing clinical and pathological features [11,12] . These tumors are pathologically recognized with lowgrade tumor differentiation, mucinous component and high signet ring cells frequency [11,13] .…”

Section: Molecular Pathogenesis Of Eocrcmentioning

confidence: 99%

“…These tumors are pathologically recognized with lowgrade tumor differentiation, mucinous component and high signet ring cells frequency [11,13] . Polyp development is contently observed during the follow-up period of EOCRC [10] .…”

Section: Molecular Pathogenesis Of Eocrcmentioning

confidence: 99%

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Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer

Tezcan

Tunca

et al. 2016

WJGO

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Colorectal cancer (CRC) is the third most frequent cancer type and the incidence of this disease is increasing gradually per year in individuals younger than 50 years old. The current knowledge is that early-onset CRC (EOCRC) cases are heterogeneous population that includes both hereditary and sporadic forms of the CRC. Although EOCRC cases have some distinguishing clinical and pathological features than elder age CRC, the molecular mechanism underlying the EOCRC is poorly clarified. Given the significance of CRC in the world of medicine, the present review will focus on the recent knowledge in the molecular basis of genetic and epigenetic mechanism of the hereditary forms of EOCRC, which includes Lynch syndrome, Familial CRC type X, Familial adenomatous polyposis, MutYH-associated polyposis, Juvenile polyposis syndrome, Peutz-Jeghers Syndrome and sporadic forms of EOCRC. Recent findings about molecular genetics and epigenetic basis of EOCRC gave rise to new alternative therapy protocols. Although exact diagnosis of these cases still remains complicated, the present review paves way for better predictions and contributes to more accurate diagnostic and therapeutic strategies into clinical approach.

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Early‐onset colorectal cancer in young individuals

et al. 2018

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Treatment of young adults with colorectal cancer (CRC) represents an unmet clinical need, especially as diagnosis in this population might lead to the greatest loss of years of life. Since 1994, CRC incidence in individuals younger than 50 years has been increasing by 2% per year. The surge in CRC incidence in young adults is particularly alarming as the overall CRC frequency has been decreasing. Early‐onset CRC are characterized by a more advanced stage at diagnosis, poorer cell differentiation, higher prevalence of signet ring cell histology, and left colon‐sided location of the primary tumor. Among EO‐CRC, approximately 30% of patients are affected by tumors harboring mutations causing hereditary cancer predisposing syndromes, and 20% have familial CRC. Most notably, the remaining 50% of EO‐CRC patients have neither hereditary syndromes nor familial CRC, thus representing a formidable challenge for research. In this review article we summarize epidemiology, clinical and molecular features, heredity and outcome of treatments of EO‐CRC, and provide considerations for future perspectives.

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Molecular Genetic Alterations and Clinical Features in Early-Onset Colorectal Carcinomas and Their Role for the Recognition of Hereditary Cancer Syndromes

Cited by 64 publications

References 40 publications

Clinical and molecular characterization of colorectal cancer in young Moroccan patients

Clinical and molecular characterization of colorectal cancer in young Moroccan patients

Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer

Early‐onset colorectal cancer in young individuals

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