Molecular evolution of human respiratory syncytial virus attachment glycoprotein (G) gene of new genotype ON1 and ancestor NA1

Hirano, Eiko; Kobayashi, Miho; Tsukagoshi, Hiroyuki; Yoshida, Lay‐Myint; Kuroda, Makoto; Noda, Masahiro; Ishioka, Taisei; Kozawa, Kunihisa; Ishii, Haruyuki; Yoshida, Ayako; Oishi, Kazunori; Ryo, Akihide; Kimura, Hirokazu

doi:10.1016/j.meegid.2014.09.030

Cited by 64 publications

(84 citation statements)

References 49 publications

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“…Rapid evolution of this gene may account for the ability of this virus to reinfect hosts by gaining advantageous mutations in this region (Botosso et al, 2009). The evolutionary rates we obtained for group A genotypes are similar to corresponding values calculated by others: 7.2 × 10 − 3 for ON1 (Ren et al, 2014) and 4.61 × 10 −3 for NA1 (Hirano et al, 2014). An expansion of the ON1 population size concurrent with its diversification was detected since its introduction, and it was accompanied with a decreasing population size trend observed for NA1.…”

Section: Discussionsupporting

confidence: 88%

“…In addition to intra-genotype diversity, p-distances were calculated between all HRSV A genotypes detected: GA5 had a mean p-distance of 0.128 and 0.134 compared to NA1 and ON1, respectively. ON1 and NA1 had much a lower mean p-distance (0.044), which is in accordance with the fact that ON1 emerged from NA1 (Hirano et al, 2014).…”

Section: Intra-and Inter-genotype Diversitysupporting

confidence: 80%

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A molecular epidemiological study of human respiratory syncytial virus in Croatia, 2011–2014

Slović

Ivancic-Jelecki

Ljubin‐Sternak

et al. 2016

Infection, Genetics and Evolution

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Section: Discussionsupporting

confidence: 88%

Section: Intra-and Inter-genotype Diversitysupporting

confidence: 80%

A molecular epidemiological study of human respiratory syncytial virus in Croatia, 2011–2014

Slović

Ivancic-Jelecki

Ljubin‐Sternak

et al. 2016

Infection, Genetics and Evolution

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“…The HRSVA genotype ON1 was first detected with a 72-nucleotide duplication in the HVR2 region encoded by the G gene in Canada in 2010. Moreover, a lineage of the ON1 genotype was identified as a new genotype (ON2) in Italy in 2015 21, 22 .…”

Section: Introductionmentioning

confidence: 99%

Emergence of ON1 genotype of human respiratory syncytial virus subgroup A in China between 2011 and 2015

Song

Zhang

Wang

et al. 2017

Sci Rep

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A molecular epidemiological study of human respiratory syncytial virus (HRSV) was conducted to examine the distribution of its subgroups and genotypes, as well as to identify its transmission pattern in China. A total of 705 samples collected from 9 provinces in China between January 2008 and February 2015 were identified as HRSV-positive and were subsequently sequenced. Of these, 336 samples were HRSV subgroup A (HRSVA), 368 samples were HRSV subgroup B (HRSVB), and 1 sample contained both HRSVA and HRSVB. These 705 HRSV sequences, together with 766 HRSV sequences downloaded from GenBank, were analyzed to understand the recent circulation patterns of HRSV in China. HRSVB predominated in the 2008/2009 and 2009/2010 seasons, whereas HRSVA predominated in the 2010/2011 and 2011/2012 seasons; HRSVA and HRSVB co-circulated during 2012/2013 and 2014/2015. Phylogenetic analysis showed most of the HRSVA sequences clustered into 2 genotypes, namely, NA1 and ON1. The ON1 genotype was first detected in China in 2011, and it quickly replaced the NA1 genotype to become the most prevalent HRSVA genotype circulating in China between 2013 and 2015. Continuous epidemiological surveillance and molecular characterization of HRSV should be conducted to monitor the evolution of HRSV in China.

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“…The ON1 genotype has been reported from 21 countries [11] including Thailand [9], China [10], Canada [5], Japan [14,15], USA [16], Kenya [17], South Africa [18], Malaysia [7], Latvia [19], India [20], Korea [21,22], Italy [23], Cyprus [24], Germany [25,26], Spain [2]. Similarly, the BA viruses were also described from various countries including Brazil [27], Belgium [28,29], Spain [30], Argentina [12,31,32,33], India [34,35], South Africa [36], Japan [37], China [38], Kenya [39,40], Saudi Arabia [41], Italy, Germany, Mexico, Argentina, USA [42] and Japan [43].…”

Section: Introductionmentioning

confidence: 99%

Co-Circulation of 72bp Duplication Group A and 60bp Duplication Group B Respiratory Syncytial Virus (RSV) Strains in Riyadh, Saudi Arabia during 2014

et al. 2016

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Respiratory syncytial virus (RSV) is an important viral pathogen of acute respiratory tract infection (ARI). Limited data are available on molecular epidemiology of RSV from Saudi Arabia. A total of 130 nasopharyngeal aspirates were collected from children less than 5 years of age with ARI symptoms attending the Emergency Department at King Khalid University Hospital and King Fahad Medical City, Riyadh, Saudi Arabia between October and December, 2014. RSV was identified in the 26% of the hospitalized children by reverse transcriptase PCR. Group A RSV (77%) predominated during the study as compared to group B RSV (23%). The phylogenetic analysis of 28 study strains clustered group A RSV in NA1 and ON1 genotypes and group B viruses in BA (BA9) genotype. Interestingly, 26% of the positive samples clustered in genotypes with duplication in the G protein gene (ON1 for group A and BA for group B). Both the genotypes showed enhanced O-linked glycosylation in the duplicated region, with 10 and 2 additional sites in ON1 and BA respectively. Selection pressure analysis revealed purifying selection in both the ON1 and BA genotypes. One codon each in the ON1 (position 274) and BA genotypes (position 219) were positively selected and had high entropy values indicating variations at these amino acid positions. This is the first report describing the presence of ON1 genotype and the first report on co-circulation of two different genotypes of RSV with duplication in the G protein gene from Saudi Arabia. The clinical implications of the simultaneous occurrence of genotypes with duplication in G protein gene in a given population especially in the concurrent infections should be investigated in future. Further, the ongoing surveillance of RSV in this region will reveal the evolutionary trajectory of these two genotypes with duplication in G protein gene from largest country in the Middle East.

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Molecular evolution of human respiratory syncytial virus attachment glycoprotein (G) gene of new genotype ON1 and ancestor NA1

Cited by 64 publications

References 49 publications

A molecular epidemiological study of human respiratory syncytial virus in Croatia, 2011–2014

A molecular epidemiological study of human respiratory syncytial virus in Croatia, 2011–2014

Emergence of ON1 genotype of human respiratory syncytial virus subgroup A in China between 2011 and 2015

Co-Circulation of 72bp Duplication Group A and 60bp Duplication Group B Respiratory Syncytial Virus (RSV) Strains in Riyadh, Saudi Arabia during 2014

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