Molecular evidence of human papillomaviruses in the retinoblastoma tumor

Javanmard, Davod; Moein, M; Esghaei, Maryam; Naseripour, Masood; Monavari, Seyed Hamidreza; Bokharaei‐Salim, Farah; Sadeghipour, Alireza

doi:10.1007/s13337-019-00540-7

Cited by 7 publications

(12 citation statements)

References 38 publications

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“…In the Central region of Brazil, screening head, neck and breast cancer patients for high-risk and low-risk HPV type gene sequences, HPV type 70 (low-risk type) was detected by the Real Time PCR (Table 1), in a patient with oral cancer (head and neck cancer group) that previously yielded negative result by the hybrid capture assay [82,83]. As stated before, findings of any viral gene sequence claimed to be enrolled in the cancer etiology is not a definitive proof, as evidences reported by Ciccarese et al [88] of HPV positivity of 51 % and 43 % among subjects with genital lesions and apparently healthy subjects, respectively; Sontakke et al [85] found 44.23 % and 5.76 % positivity for HPV type 16 and HPV type 18 respectively, in a group of asymptomatic women with normal cervix, while women with benign cervical lesion had 38.46% and 3.84% HPV type 16 and HPV type 18 positivity respectively, and 62.5 % and 22.5% HPV type 16 and 18 positivity respectively, in a group of women with cervical malignancy. As observed, HPV positivity ratio is elevated among cancer patients, anyway healthy subjects harbor HPV genome.…”

Section: Discussionmentioning

confidence: 93%

Putative oncogenic viruses: Some data on Brazilian subjects

Tenorio¹,

Bretas²,

Bernardes³

et al. 2021

Integr Cancer Sci Therap

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The concepts of cancer etiology have changed over the years, mainly based on molecular epidemiology studies and bioinformatics approaches. Until relatively recently the most accepted theory of cancer etiology has dealt with the accumulation of gene mutations and the consequent cognate proteins dysfunction, but now some authors have argued against the proposed theory. The additional role of noncellular genes in the cause of malignancy, associated to environmental factors and host genetic background, has been proposed and mostly accepted by the scientific community. Some of our data from human populations in Brazil concerning cancer epidemiology, molecular and serological surveys, were conducted looking for the detection of putative oncogenic viruses, as the Human T-cell Lymphotropic virus/ HTLV-1/2, Human Papillomavirus/HPV, the Mouse or Human Mammary Tumor Virus/MMTV, the Human Endogenous Retrovirus/HERVs and the Hepatitis C virus/HCV, in human, healthy and malignized, tissues. Generally, research work around the world suggests that 10 to 20 % of all human cancers are etiologically linked to oncogenic viruses, so if the presence of exogenous or endogenous virus sequences in the human DNA has any significancy in the cancer etiology, it deserves further and continuous research work and discussion.

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Section: Discussionmentioning

confidence: 93%

Putative oncogenic viruses: Some data on Brazilian subjects

Tenorio¹,

Bretas²,

Bernardes³

et al. 2021

Integr Cancer Sci Therap

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“…The scientists claimed that their finding may suggest a presumptive link between infection with HPV and incidence of sporadic RB. 31 …”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, they found out that the HPV‐positive RB cases all had unilateral and unfamiliar sporadic RB tumors. The scientists claimed that their finding may suggest a presumptive link between infection with HPV and incidence of sporadic RB 31 …”

Section: Discussionmentioning

confidence: 99%

“…The scientists claimed that their finding may suggest a presumptive link between infection with HPV and incidence of sporadic RB. 31 Also, Anand et pRB, which is the main target of the HPV-E7 oncogene, also revealed that the protein is not expressed in the majority of the HPV-positive cases. Finally, they observed a statistically significant association between HPV and pRB expression status.…”

Section: Javanmard Et Al Assessed the Prevalence Of Hpv-dna Amongmentioning

confidence: 99%

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HPV infections in retinoblastoma: a systematic review

Soltani

Tabibzadeh

Yousefi

et al. 2021

Clinical Laboratory Analysis

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Background: Retinoblastoma is the most common primary intraocular malignancy in children less than 4 years. Retinoblastoma (RB) contains about 3%-5% of all childhood cancers. Recent studies demonstrated that interacting between RB tumor suppressor and oncoproteins of DNA tumor viruses such as human papillomavirus (HPV). The objective of the current systematic review study was to present conducted studies in the field of HPV infection and its possible role in retinoblastoma.Methods: For this systematic review, all relevant original research studies were assessed by searching in electronic databases include PubMed, Embase, Scopus, Google Scholar, and Web of Science by using relevant keywords. The study was designed based on the PRISMA criteria. All publications with English literature and original researches are considered for screening. Results:Conducted search results lead to 4070 studies. The title and abstract screening lead to 11 studies. Data extraction was performed on 8 included studies. The prevalence of the HPV was ranged from 0 to 69%, and HPV genotype 16 and 18 were the most detected types. The most used method for the detection of the viruses was PCR, and the most assessed sample was formalin-fixed, paraffin-embedded tissue blocks. Conclusion:The association between HPV and retinoblastoma is still inconsistent.The prevalence of the HPV in RB was ranged from 0 to 69%, which indicates a wide range and highlights the importance of further investigation for more accurate statistical of HPV prevalence in RB. Thus, further worldwide studies of larger sample sizes of cohorts should be investigated to clarify this uncertainty.

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“…The prevalence of HPV in retinoblastoma has been shown with wide variations in different populations (4.6% - 69.7%) with the use of molecular methods for viruses detection (Antoneli et al, 2011; Bhuvaneswari et al, 2012; Espinoza et al, 2005; Gillison et al, 2007; Javanmard et al, 2019; Mohan et al, 2009; Montoya-Fuentes et al, 2003; Orjuela et al, 2000; Palazzi et al, 2003; Shetty et al, 2012; Shukla et al, 2009). Additionally, techniques such as in situ hybridization and immunohistochemistry have been performed and allowed possible causal relationship between HPV and RB development (Antoneli et al, 2011; Bhuvaneswari et al, 2012; Espinoza et al, 2005; Gillison et al, 2007; Palazzi et al, 2003; Shetty et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Detection of early and late Human Papillomaviruses (HPV) proteins in Retinoblastoma tumors

Pessoa

Melo

Araldi

et al. 2020

Preprint

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In this study, we evaluated the presence of early and late Human Papillomavirus (HPV) proteins in retinoblastoma Brazilian patients. For this, 8 formalin-fixed paraffin-embedded retinoblastoma tissue blocks were used. HPV DNA presence was determined by in situ hybridization (ISH). Immunohistochemistry were performed to verify HPV16/18 E6, E1^E4, and L1 proteins. HPV was detected in all retinoblastoma tumors and viral DNA was labeled in tumor cells, retinal layers and optical nerve structures. In addition, E1^E4, E6 and L1 proteins were detected in all samples in the same areas where HPV DNA was detected. Our data showed the presence and expression of early and late HPV proteins in retinoblastoma tumors from Brazilian children. However, further studies should be performed to clarify the role of HPV infection in retinoblastoma tumor.

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Molecular evidence of human papillomaviruses in the retinoblastoma tumor

Cited by 7 publications

References 38 publications

Putative oncogenic viruses: Some data on Brazilian subjects

Putative oncogenic viruses: Some data on Brazilian subjects

HPV infections in retinoblastoma: a systematic review

Immunohistochemical Detection of early and late Human Papillomaviruses (HPV) proteins in Retinoblastoma tumors

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