HPV infections in retinoblastoma: a systematic review

Abstract

Background: Retinoblastoma is the most common primary intraocular malignancy in children less than 4 years. Retinoblastoma (RB) contains about 3%-5% of all childhood cancers. Recent studies demonstrated that interacting between RB tumor suppressor and oncoproteins of DNA tumor viruses such as human papillomavirus (HPV). The objective of the current systematic review study was to present conducted studies in the field of HPV infection and its possible role in retinoblastoma.Methods: For this systematic review, all relevant original research studies were assessed by searching in electronic databases include PubMed, Embase, Scopus, Google Scholar, and Web of Science by using relevant keywords. The study was designed based on the PRISMA criteria. All publications with English literature and original researches are considered for screening. Results:Conducted search results lead to 4070 studies. The title and abstract screening lead to 11 studies. Data extraction was performed on 8 included studies. The prevalence of the HPV was ranged from 0 to 69%, and HPV genotype 16 and 18 were the most detected types. The most used method for the detection of the viruses was PCR, and the most assessed sample was formalin-fixed, paraffin-embedded tissue blocks. Conclusion:The association between HPV and retinoblastoma is still inconsistent.The prevalence of the HPV in RB was ranged from 0 to 69%, which indicates a wide range and highlights the importance of further investigation for more accurate statistical of HPV prevalence in RB. Thus, further worldwide studies of larger sample sizes of cohorts should be investigated to clarify this uncertainty.

Human Papillomavirus Infection during Pregnancy and Childhood: A Comprehensive Review

“…The E7 protein produced by the high-risk HPV types 16 and 18 bind more avidly to the RB protein than those encoded by low-risk types [ 152 ]. The binding, interaction, and subsequent inhibition of the RB protein by E7 is the suggested theory for the carcinogenesis of high-risk HPV types [ 153 ]. As RB tumor suppressor gene inactivation has been linked to a range of malignancies, including RB, the hypothesis of the possible role of HPV in RB development has strengthened.…”

“…As RB tumor suppressor gene inactivation has been linked to a range of malignancies, including RB, the hypothesis of the possible role of HPV in RB development has strengthened. Therefore, several studies have evaluated the prevalence of HPV in the intraocular samples of patients with RB [ 150 , 153 , 154 , 155 ]. HPV has been detected in RB samples from 0% to 82% of the study participants in different investigations [ 150 , 153 ].…”

Advances in early diagnosis of cervical cancer based on biosensors

“…On the other hand, the main disadvantage of the liquid‐based cytology method is that it is not an economical test, as it is more costly than the pap smear test. Also, only a trained person can conduct this test, and it is also not appropriate for use on a sample with limited resources (Karnon et al, 2004; León‐Ordóñez et al, 2019; Soltani et al, 2021). Visual inspection with acetic acid is the third most commonly used conventional technique that is carried out in low‐resource settings; in addition, its specificity is limited (Mahmoodi et al, 2019).…”

Retinoblastoma Em Pacientes Pediátricos: Uma Visão Geral

“…Nas causas genéticas, uma alteração do gene do retinoblastoma (RB1), que codifica uma proteína supressora tumoral relevante no ciclo celular, pode desencadear uma proliferação celular desordenada e, consequentemente, promover o desenvolvimento do tumor (KAEWKHAW & ROJANAPORN, 2020). Nos fatores de riscos ambientais, a presença do papiloma vírus oncogênico humano (HPV) pode inativar a proteína retinoblastoma (pRB) através de sua oncoproteína HPV-16 e HPV-18 e isso sugere que esse vírus atue como um agente do desenvolvimento de retinoblastomas (SOLTANI et al, 2021). Para mais, há relatos que associam a etiologia do retinoblastoma a baixa ingesta de folato durante a gravidez (AERTS et al, 2006).…”