Molecular epidemiology of human and animal tuberculosis in Ibadan, Southwestern Nigeria

Jenkins, Akinbowale Olajide; Cadmus, Simeon; Venter, Estelle Hildegard; Pourcel, Christine; Hauk, Y.; Vergnaud, Gilles; Godfroid, Jacques

doi:10.1016/j.vetmic.2011.02.037

Cited by 60 publications

(57 citation statements)

References 24 publications

(36 reference statements)

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“…We observed that infections by M. bovis and M. tuberculosis were prevalent in cattle and humans, respectively. This is generally in agreement with what has been observed regarding the host preference of these two members of MTC [33]. However, two isolates of M. bovis were recovered from human sputum, suggesting human exposure to zoonotic TB.…”

Section: Discussionsupporting

confidence: 91%

Characterization ofMycobacterium bovisfrom Humans and Cattle in Namwala District, Zambia

Malama

Johansen

Muma

et al. 2014

Veterinary Medicine International

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Tuberculosis remains a major public health problem in Zambia. While human to human transmission of Mycobacterium tuberculosis is of major importance in driving the tuberculosis epidemic, the impact of Mycobacterium bovis transmission from infected cattle is largely unknown. This cross-sectional study aimed at molecular characterization of M. bovis in humans and cattle. A total of 100 human sputum samples and 67 bovine tissues were collected and analyzed for the presence of mycobacteria. Of 65 human samples that harbored acid fast bacteria (AFB), 55 isolates were obtained of which 34 were identified as M. tuberculosis and 2 as M. bovis. AFB-positive bovine samples (n = 67) yielded 47 mycobacterial isolates among which 25 were identified as M. bovis and no M. tuberculosis was found. Among the M. bovis isolates, spoligotyping revealed a high homogeneity in genotypes circulating in Namwala district. Human and cattle isolates shared identical MIRU-VNTR genotypes, suggesting that transmission between the two hosts may occur. Therefore, this study has documented zoonotic TB in human patients in Namwala district of Zambia. However, further molecular epidemiological studies in the study area are recommended.

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Section: Discussionsupporting

confidence: 91%

Characterization ofMycobacterium bovisfrom Humans and Cattle in Namwala District, Zambia

Malama

Johansen

Muma

et al. 2014

Veterinary Medicine International

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“…This result was lower than previous reports of prevalence of BTB in neighbouring Nasarawa State where prevalence of 15.08% was reported among cattle population [29], in Taraba State was 2.8% [30], and in other parts of the country such as in abattoirs in Oyo State was 4.47% [15]. Lower prevalence was reported in Ogbomosho, 0.54% [28].…”

Section: Discussioncontrasting

confidence: 62%

“…Bovine tuberculosis was first reported in Nigeria by Manley [14]; since then a lot of information on bovine tuberculosis had been reported [7, 8, 15–19], but no information on the economic losses due to condemnation of meat resulting from detection of tuberculosis lesions has been reported. Furthermore, there is no active national bovine tuberculosis surveillance and control at herd level and farms in Nigeria [20].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Direct Economic Losses from Bovine Tuberculosis in Makurdi, Nigeria

Ejeh

Raji

Bellò

et al. 2014

Veterinary Medicine International

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A retrospective study was conducted to investigate the prevalence of bovine tuberculosis and direct economic losses (DEL) from tuberculosis in cattle slaughtered in Makurdi abattoirs from 2008 to 2012, using abattoir records obtained from the Ministry of Agriculture and Natural Resources. Out of 61654 cattle slaughtered during the study period 1172 (1.90%) were positive for tuberculosis lesions. The annual prevalence of bovine tuberculosis ranges from 0.90% in 2008 to 4.04% in 2012. There was significant (P < 0.05) difference in annual prevalence of bovine tuberculosis. It was also observed that there was no seasonal difference in the prevalence of bovine tuberculosis. A total of 1935 affected organs by BTB weighing 3046.50 kg, amounting to 2.91 × 106 Naira (1.82 × 104 USD), were condemned within the study period. Seasonal variation in organ condemnation due to bovine tuberculosis was significantly different (Mann-Whitney U statistics = 774 × 103, P = 0.034). It was concluded that bovine tuberculosis is prevalent in Makurdi and accounts for heavy economic losses due to condemnation of edible organs.

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“…The fact that all the M. tuberculosis isolates obtained from the cattle with granulomatous lesion detection after the slaughtering belonged to the T1 family in this study matches up with the results of Jenkins et al [21] . It is stated in the studies related to the molecular epidemiology of the M. tuberculosis belonging to the people in our country that the M. tuberculosis Beijing strains have started to be observed at growing rates [17,22,23] .…”

Section: Discussionsupporting

confidence: 92%

Türkiye’de Sığırlardan İzole Edilen M. tuberculosis Suşlarının Spoligotiplendirmesi

Tuzcu¹,

Kayar²,

Uysal³

et al. 2015

Kafkas Univ Vet Fak Derg

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Although it is generally accepted that M.bovis leads to tuberculosis in cattle, there are statements given from the different regions of the world, referring to the fact that M. tuberculosis, which is known as the human tuberculosis agent, causes tuberculosis in cattle as well. The material of the study consisted of 13 M. tuberculosis isolates which were isolated and identified from the organ pieces of 95 cattle with the culture methods; these organ pieces had been taken from the cattle with granulomatous lesion detection after the slaughtering in slaughterhouses located in Çukurova region and brought to the laboratory under sterile conditions. It was determined in the genotyping conducted by using the Spoligotyping method that 13 of the 55 isolates were M. tuberculosis and they belonged to the T1 family (SIT53) by becoming dense in one cluster (100%). Consequently, it was shown with this study that M. tuberculosis, which leads to tuberculosis in humans, could be transmitted from humans to animals and from animals to humans again, and researching the human and epidemiological tuberculosis cases by using molecular epidemiology-based methods such as spoligotyping might provide useful information about explaining the ways of transmission of tuberculosis. Türkiye'de Sığırlardan İzole Edilen M. tuberculosis Suşlarının Spoligotiplendirmesi Özet Tüberkülozise sığırlarda, M. bovis'in sebep olduğu genel olarak kabul edilmesine rağmen insan tüberkülozis etkeni olarak bilinen M. tuberculosis'in de sığırlarda tüberkülozise neden olduğuna dair dünyanın farklı bölgelerinden yapılmış bildirimler bulunmaktadır. Çalışmanın materyalini Çukurova bölgesinde bulunan mezbahalarda kesim sonrası granülamatöz lezyon tespit edilen sığırlardan alınan ve steril şartlarda laboratuvara ulaştırılan 95 adet sığıra ait organ parçalarından kültür yöntemleri ile izole ve identifiye edilen 13 adet M. tuberculosis izolatı oluşturdu. Spoligotyping yöntemi ile yapılan genotiplendirmede 55 izolattan 13 tanesinin M. tuberculosis olduğu ve bunların tek bir küme içerisinde yoğunlaşarak (%100) T1 ailesine (SIT53) ait olduğu belirlendi. Sonuç olarak bu çalışma ile insanlarda tüberkülozise neden olan M. tuberculosis'in insanlardan hayvanlara, hayvanlardan da tekrar insanlara bulaşabileceği, insan ve hayvan kaynaklı tüberkülozis vakalarının spoligotyping gibi moleküler epidemiyolojik temelli yöntemlerle araştırılmasının tüberkülozisin bulaş yollarının açıklanması konusunda faydalı bilgiler verebileceği gösterilmiştir.

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Molecular epidemiology of human and animal tuberculosis in Ibadan, Southwestern Nigeria

Cited by 60 publications

References 24 publications

Characterization ofMycobacterium bovisfrom Humans and Cattle in Namwala District, Zambia

Characterization ofMycobacterium bovisfrom Humans and Cattle in Namwala District, Zambia

Prevalence and Direct Economic Losses from Bovine Tuberculosis in Makurdi, Nigeria

Türkiye’de Sığırlardan İzole Edilen M. tuberculosis Suşlarının Spoligotiplendirmesi

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