Molecular epidemiology of Hepatitis B virus in Córdoba, Argentina

Gallego, Fernando Martín; Pisano, María Belén; Torres, Carolina; Caeiro, Luciana; Wassaf, Maribel Graciela Martínez; Balangero, Marcos; Campos, Rodolfo Héctor; Ré, Viviana Elizabeth

doi:10.1016/j.jcv.2014.06.030

Cited by 12 publications

(22 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have described the circulation of this gt in Argentina, particularly in the metropolitan area of Buenos Aires and the Central region. However the prevalence reported in this areas were lower than that found in Misiones (Barbini et al, 2013;Gallego et al, 2014;González López Ledesma et al, 2015;Piñeiro y Leone et al, 2008). On the contrary, a higher prevalence has been reported in the Southern region of Brazil (Bertolini et al, 2012;Carrilho et al, 2004;Mello et al, 2007;Reis et al, 2011), suggesting that the HBV epidemiology of Misiones resembles that found in this neighboring area more than that described for other regions of Argentina.…”

Section: Discussioncontrasting

confidence: 58%

“…Nonetheless, in 2011 a national prevalence study in blood donors was carried out showing a prevalence of 0.198% for HBsAg and 2.007% for Anti-HBc; in particular, significantly higher prevalences have been found for the Northwestern and Northeastern regions (Flichman et al, 2014). Previous studies described the HBV molecular epidemiology in the metropolitan area of Buenos Aires, and Central and Northwest regions of the country (Gallego et al, 2014;Pezzano et al, 2011;Piñeiro y Leone et al, 2008). However, there is a paucity of data in regard to the circulating viral gts in the Northeast region, where a higher HBV prevalence and singular demographic characteristics are noticed.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Molecular epidemiology of hepatitis B virus in Misiones, Argentina

Mojsiejczuk

Torres

Sevic

et al. 2016

Infection, Genetics and Evolution

Self Cite

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Molecular epidemiology of hepatitis B virus in Misiones, Argentina

Mojsiejczuk

Torres

Sevic

et al. 2016

Infection, Genetics and Evolution

Self Cite

View full text Add to dashboard Cite

“…All genotype F strains were F1b of the subgenotype. The high similarity of Uruguayan genotype F strains (based on complete and partial genome sequences) has also been reported by other authors [62,63]. The Uruguayan HBV genotypes identified in this study reflect the three main origins of the Uruguayan population (European, African and Amerindian).…”

Section: Discussionsupporting

confidence: 87%

“…The following genotypes were identified: 8 genotype F1b (47 %), 3 genotype A3 (17.6 %), 2 genotype A2 (11.7 %) and 4 genotype D (23.5 %). This pattern of HBV genotype prevalence has also been reported in other countries in South and Central America [27,37,39,62,63]. All genotype F strains were F1b of the subgenotype.…”

Section: Discussionsupporting

confidence: 84%

“…Subgenotype F1 has been found in Alaska, El Salvador, Guatemala, Costa Rica, and Nicaragua [25,29,40], whereas the F1b genotype has been reported in Peru, Chile and Argentina [27,30,34,[40][41][42][43]. Subtype 2 is the most common in Venezuela and Brazil [31,32,35,[37][38][39][40][41][42][43][44], particularly F2a. Subgenotype F3 has been described in Venezuela, Colombia, and Panama [45,46].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants

López¹,

Flichman

Mojsiejczuk

et al. 2015

Arch Virol

View full text Add to dashboard Cite

Hepatitis B virus (HBV) infection is a serious global health problem. Approximately 2 billion people worldwide have been infected, and approximately 350 million individuals currently suffer from HBV-induced chronic liver infection, which causes 600,000 deaths annually from chronic hepatitis, cirrhosis and hepatocellular carcinoma. HBV is classified in eight genotypes (A-H), and two more have been proposed (I-J). In this paper, complete genome sequences of nine Uruguayan HBV are reported. Five samples belong to genotype F1b and one to genotype A2. Three HBV recombinants were detected: A1/F1b, A2/F1b and D3/F1b. The following mutations were detected: a G1896A substitution, a 33-nucleotide deletion from position 2896 to 2928 in the Pre-S1 region involving Pre-S1 residues 3-13, a 33-nt deletion in the Pre-S1 region involving nt 2913-2945 and Pre-S1 residues 9-19. More F genotypes strains than expected were detected in this study, supporting the hypothesis that there are more people of indigenous origin than declared in our population. Also, one third of the samples analyzed were recombinants. This cannot be explained by the low HBV prevalence in Uruguay, but a high HBV infection rate in drug addicts and dialysis patients could act in favor of multiple-genotype HBV infections that could lead to recombination.

show abstract

Hepatitis B virus in Mar del Plata, Argentina: Genomic characterization and evolutionary analysis of subgenotype F1b

Torres¹,

Civetta²,

D'Amico

et al. 2019

Journal of Medical Virology

View full text Add to dashboard Cite

The aim is to describe the molecular epidemiology and perform a genomic characterization of hepatitis B virus (HBV) circulating in Mar del Plata and to identify the origin and diversification patterns of the most prevalent genotype. The S gene and the region encompassing the X gene, basal core promoter (BCP), and precore (preC) was analyzed in 56 samples. They were genotyped as: 80% F1b, 9% A2, 7% D3, and 2% D1. A recombinant F4/D2 genome was detected. The double substitution G1764A/A1762T at the BCP (reduced HBeAg expression) was found in 20% F1b, 2% A2, 2% D1, and 2% D3 samples. A unique D3 presented the G1896A substitution at the preC (HBeAg negative phenotype). A 13% of the samples showed mutations at the HBsAg “a” immunodeterminant (escape from neutralizing antibodies). Mutations at the polymerase (antiviral resistance) were found in 52% of the samples. Coalescent analysis of subgenotype F1b, the most prevalent in the city, showed that viral diversification in Mar del Plata started by year 2000. F1b was the most prevalent genotype detected, being a characteristic of actual HBV infections in Mar del Plata. Local HBV exhibit clinically relevant mutations, but a minority of them was shown to be associated to potential vaccination escape or antiviral resistance. Nevertheless, further studies are needed to determine whether any of these mutants could pose a threat to prevention, diagnosis, or treatment.

show abstract

Molecular epidemiology of Hepatitis B virus in Córdoba, Argentina

Cited by 12 publications

References 43 publications

Molecular epidemiology of hepatitis B virus in Misiones, Argentina

Molecular epidemiology of hepatitis B virus in Misiones, Argentina

Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants

Hepatitis B virus in Mar del Plata, Argentina: Genomic characterization and evolutionary analysis of subgenotype F1b

Contact Info

Product

Resources

About