Molecular epidemiology of hepatitis B virus in Misiones, Argentina

Mojsiejczuk, Laura; Torres, Carolina; Sevic, Ina; Badano, Inés; Malan, Richard; Flichman, Diego Martín; Liotta, Domingo Javier; Campos, Rodolfo Héctor

doi:10.1016/j.meegid.2016.06.032

Cited by 17 publications

(13 citation statements)

References 59 publications

(82 reference statements)

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“…However, in this study, subgenotype F1b was notably present in 57% of the native cases (NOaxaca and NMichoacan) showing a closely genetic relatedness with other Latin American F1b strains. Other than the F1b cluster recently reported in Italy, this subgenotype that is more common among the western South American countries of Argentina and Chile has also been found in natives of Colombia and in Venezuela . Despite that HBV genotype H is most predominant in native Mexicans, the F1b strains found in Oaxaca were isolated from descendants of the ancient Mesoamerican Mixtecos.…”

Section: Discussionmentioning

confidence: 68%

“…Thereby, the endemic genotype H in Mexico and the F1‐F4 subgenotypes of Central and South America correspondingly circulate among natives, rural, or urban, low‐income class Mestizo subpopulations. Likewise, genotypes A, D, or B, C that circulate among urban populations of European descendants and Asian immigrants, respectively have been related to liver damage . However, the features aforementioned have not been thoroughly studied among Mexican risk groups.…”

Section: Introductionmentioning

confidence: 99%

“…Likewise, genotypes A, D, or B, C that circulate among urban populations of European descendants and Asian immigrants, respectively have been related to liver damage. [18][19][20] However, the features aforementioned have not been thoroughly studied among Mexican risk groups.…”

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confidence: 99%

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High prevalence of HBV infection, detection of subgenotypes F1b, A2, and D4, and differential risk factors among Mexican risk populations with low socioeconomic status

José-Ábrego

Panduro

Fierro

et al. 2017

Journal of Medical Virology

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Hepatitis B virus (HBV) infection may be underestimated among high-risk individuals in regions of low HBs antigenemia. This study aimed to assess HBV serological markers, genotypes, and risk factors in Mexican patients with risk of HBV infection and low socioeconomic status. Demographics, clinical, and risk factor data were collected in patients with HIV (n = 289), HCV (n = 243), deferred blood donors (D-BD) (n = 83), and two native populations, Mixtecos (n = 57) and Purepechas (n = 44). HBV infection was assessed by HBsAg, anti-HBc, and HBV-DNA testing. Overall, patients had low education and very-low income. Totally, HBsAg prevalence was 16.5% (113/684) ranging from 0.7% (HCV) to 37.3% (D-BD), while anti-HBc was 30.2% (207/684). Among 52 sequences, genotypes H (n = 34, 65.4%), G (n = 4, 7.7%), subgenotypes F1b (n = 7, 13.5%), A2 (n = 6, 11.5%), and D4 (n = 1, 1.9%) were detected. Surgeries, sexual promiscuity, and blood transfusions had a differential pattern of distribution. In HCV patients, single (OR = 5.84, 95%Cl 1.91-17.80, P = 0.002), MSM (OR = 4.80, 95%Cl 0.75-30.56, P = 0.097), and IDU (OR = 2.93, 95%CI 1.058-8.09, P = 0.039) were predictors for HBV infection. While IDU (OR = 2.68, 95%CI 1.08-6.61, P = 0.033) and MSM (OR = 2.64, 95%CI 1.39-5.04, P = 0.003) were predictors in HIV patients. In this group, MSM was associated with HBsAg positivity (OR = 3.45, 95%CI 1.48-8.07, P = 0.004) and IDU with anti-HBc positivity (OR = 5.12, 95%CI 2.05-12.77, P < 0.001). In conclusion, testing with a combined approach of three different HBV markers, a high prevalence of HBV infection, a differential distribution of HBV genotypes, including subgenotypes F1b, A2, and D4, as well as risk factors in low-income Mexican risk groups were detected.

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Section: Discussionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

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High prevalence of HBV infection, detection of subgenotypes F1b, A2, and D4, and differential risk factors among Mexican risk populations with low socioeconomic status

José-Ábrego

Panduro

Fierro

et al. 2017

Journal of Medical Virology

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“…Between amerindian groups in the Americas it is almost exclusively the unique circulating gt, being considered, therefore, the indigenous representative of HBV in this continent . Northern Argentina, particularly, has a strong native population background and thus a high prevalence of gt F …”

Section: Discussionmentioning

confidence: 99%

“…26 Between amerindian groups in the Americas it is almost exclusively the unique circulating gt, being considered, therefore, the indigenous representative of HBV in this continent. 32 Northern Argentina, particularly, has a strong native population background and thus a high prevalence of gt F. 33,34 Since its foundation in 1874, the city of Mar del Plata was the high-rise prevalence of sgt F1b in the city and supports the idea that many people arrived to the city harboring the autochthonous HBV gt from Latin America. 5,27 Furthermore, sgt F1b is the main gt in anti-HBc IgM (+) samples of this cohort, suggesting that is the main responsible for HBV new infections in Mar del Plata.…”

Section: F1b Sgt Was Introduced Near Year 2000 and Since Then It Hamentioning

confidence: 93%

Hepatitis B virus in Mar del Plata, Argentina: Genomic characterization and evolutionary analysis of subgenotype F1b

Torres¹,

Civetta²,

D'Amico

et al. 2019

Journal of Medical Virology

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The aim is to describe the molecular epidemiology and perform a genomic characterization of hepatitis B virus (HBV) circulating in Mar del Plata and to identify the origin and diversification patterns of the most prevalent genotype. The S gene and the region encompassing the X gene, basal core promoter (BCP), and precore (preC) was analyzed in 56 samples. They were genotyped as: 80% F1b, 9% A2, 7% D3, and 2% D1. A recombinant F4/D2 genome was detected. The double substitution G1764A/A1762T at the BCP (reduced HBeAg expression) was found in 20% F1b, 2% A2, 2% D1, and 2% D3 samples. A unique D3 presented the G1896A substitution at the preC (HBeAg negative phenotype). A 13% of the samples showed mutations at the HBsAg “a” immunodeterminant (escape from neutralizing antibodies). Mutations at the polymerase (antiviral resistance) were found in 52% of the samples. Coalescent analysis of subgenotype F1b, the most prevalent in the city, showed that viral diversification in Mar del Plata started by year 2000. F1b was the most prevalent genotype detected, being a characteristic of actual HBV infections in Mar del Plata. Local HBV exhibit clinically relevant mutations, but a minority of them was shown to be associated to potential vaccination escape or antiviral resistance. Nevertheless, further studies are needed to determine whether any of these mutants could pose a threat to prevention, diagnosis, or treatment.

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