Molecular epidemiology of Coxsackievirus B3

Chu, Pei‐Yu; Ke, Guan-Ming; Chen, Yao-Shen; Lu, Po‐Liang; Chen, Hsiu-Lin; Lee, Min‐Sheng; Chen, Bao-Chen; Huang, Tsi-Shu; Li, Yuchen; Chou, Li-Chiu; Wang, Shengyu; Lin, Kuei-Hsiang

doi:10.1016/j.meegid.2010.04.004

Cited by 18 publications

(11 citation statements)

References 25 publications

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“…This implies that, unlike the 85% rule for amino acids, the 75% rule for nucleotides may not be universally applicable, especially in a long-term analysis of a viral lineage such as E-30, which has high genetic diversity and rapid turnover [5,14,29]. We reported similar results in our previous molecular epidemiology study of CVB3 [32]. A recent report proposed an even more stringent value for VP1 amino acid identity (88%) in the routine typing of HEV-C [33].…”

Section: Discussionsupporting

confidence: 67%

Molecular epidemiology of Echovirus 30 in Taiwan, 1988–2008

Lin

et al. 2011

Virus Genes

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To investigate the molecular epidemiology of Taiwanese Echovirus 30 (E-30) strains, we analyzed the 876 bp sequence of the VP1 gene from 32 Taiwanese strains isolated in 1988-2008, 498 reference sequences, and one Echovirus 21 strain as the out-group. Phylogenetic analysis detected six E-30 genotypes (designated GI-GVI) that had circulated globally during the past five decades. The genotypes varied widely in geographic distribution and circulation half-life. The GI, GII, and GV were ancient genotypes in which the first strains emerged in the 1950s. The GIII was a reemerging genotype, in which strains had first appeared in Colombia in 1995 before reemerging in the New Independent States (NIS) in 2003. The GIV, an emerging genotype that recently appeared in Asia in 2003, was closely related to the ancient genotypes. The GVI was the circulating genotype, which included eight clusters (A-H) that had circulated since 1967. No GVI-A, C, D, or E strains have been identified during the past 10 years. The GVI-B first appeared in China in 1984 and later in Russia and Asia in the 2000s. The GVI-F, G, and H strains, which comprised the prevalent clusters, had been dominant in Asia Pacific area, globally, and Europe, respectively. Taiwanese strains were classified into GVI-D (1988-1989), GVI-F (1993-2004), and GVI-G (1993-2008). The quiescence period of E-30 is longer in Taiwan (5-8 years) than in other countries (3-5 years).

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Section: Discussionsupporting

confidence: 67%

Molecular epidemiology of Echovirus 30 in Taiwan, 1988–2008

Lin

et al. 2011

Virus Genes

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“…The other two genotype A strains identified in Beijing and Heilongjiang were not known to have an association with HFMD. In contrast, the majority (over 80%) of the genotype G strains were isolated from patients with aseptic meningitis or myocarditis, and only a few were from HFMD patients (Chu et al, 2010;Tao et al, 2012Tao et al, , 2014Wong et al, 2011). These results indicated that the CVB3 infection is not only a pathogenic factor in heart and neurological diseases, but also in HFMD.…”

Section: Discussionmentioning

confidence: 85%

“…Coxsackievirus B3 (CVB3) is a pathogenic enterovirus that belongs to the genus Enterovirus of the family Picornaviridae (Lukashev and Vakulenko, 2017). It was previously divided into five genotypes by alphabetical (A-E) or Roman numeral (I-V) orders (Chu et al, 2010;Laxmivandana et al, 2016;Calderon et al, 2016;Tao et al, 2012;Tian et al, 2014;Wong et al, 2011), but lacked supporting evidence from both phylogenetic and distance analyses that are prerequisites for the genotyping of viruses (Smith et al, 2014). CVB3 has a global distribution and is one of the most common pathogens causing aseptic meningitis, encephalitis, myocarditis and acute flaccid paralysis (Henke et al, 2003;Kim and Nam, 2010); it can result in serious complications especially in neonates and immunocompromised patients (Bendig et al, 2003;Spanakis et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

High proportion of coxsackievirus B3 genotype A in hand, foot and mouth disease in Zhenjiang, China, 2011–2016

Mao

Wan

et al. 2019

International Journal of Infectious Diseases

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Background: Hand, foot and mouth disease (HFMD) is usually caused by EVA71 and CVA16 except for a few cases that are caused by non-EVA71 non-CAV16 enteroviruses. Coxsackievirus B3 (CVB3) is mostly associated with myocarditis, occasionally with HFMD. Methods: The partial VP1 gene of enteroviruses were amplified and sequenced from 610 throat swabs from clinically confirmed HFMD children. All available CVB3 near full-length genomic and VP1 sequences were downloaded from GenBank. Phylogenetic and distance analyses were performed using MEGA 7.0. Results: A total of 238 partial VP1 sequences were obtained, including 93 EVA71 (39%), 79 CAV16 (33%), 29 CVB3 (12%), 24 CVA6 (10%), and 13 other enterovirus serotypes (5.5%). CVB3 is classified into seven genotypes A-G according to phylogenetic and distance analyses. All CVB3 strains from Zhenjiang belonged to genotype A. In contrast to other genotypes that are prevalent in Europe and other regions of China, and often associated with aseptic meningitis and myocarditis, CVB3 genotype A strains identified in Zhenjiang were only detected among HFMD patients. Conclusions: This high prevalence of CVB3 genotype A among HFMD children has never been reported. This phenomenon has revealed a new epidemic trend of CVB3 among HFMD in China, and it has epidemiological implications for monitoring the epidemic risk of CVB3.

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“…5 Based on a previous study, five genogroups are identified among the CV-B3 strains. 8 This study analyzed more than 100 VP1 nucleotide sequences in CV-B3 strains isolated worldwide. Fifteen Taiwan isolates were separated in four different subgenogroups (i.e., GV-A, GV-B, GIII, and GIV).…”

Section: Discussionmentioning

confidence: 99%