Molecular epidemiology of Echovirus 30 in Taiwan, 1988–2008

Ke, Guan M.; Lin, Kuei Hsiang; Lu, Po Liang; Tung, Yi Chin; Wang, Chu Feng; Ke, Liang‐Yin; Lee, Min Sheng; Lin, Pei‐Chen; Su, Hui Ju; Lin, Yi; Huang, Tzu Ping; Wang, Jen Ren; Wang, Sheng Yu; Hsu, Li Ching; Chu, Pei Yu

doi:10.1007/s11262-010-0565-5

Cited by 7 publications

(4 citation statements)

References 40 publications

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“…In the ECHO30 study, we found the average length for VP1 amplification to be 877 bp, which coded for 292 amino acids. It was reported that F122L, found mainly in the E30_h group, was thought to be one of the conserved positions of the drug-binding pocket [23]. Amino acid position 285, which is located at the end of the C terminal of VP1, was identified as variable (T285A) in our sequences.…”

Section: Discussionmentioning

confidence: 79%

Molecular Epidemiology and Prevalence of Echovirus 30 in Zhejiang Province, China, from 2002 to 2015

Chen

Sun

Yan

et al. 2017

Journal of Microbiology and Biotechnology

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Echovirus serotype 30 (ECHO30) has been responsible for several recent worldwide outbreaks of viral meningitis. In Zhejiang Province, China, ECHO30 has been one of the main causes of viral meningitis for years. This study, using phylogenetic analysis of the VP1 gene, was performed to investigate the general molecular epidemiology and genetic patterns of ECHO30 circulating in Zhejiang Province between the years 2002 and 2015. The nucleotide sequences of ECHO30 VP1 showed that they were 64.8% identical with the prototype strain, Bastianni, while the amino acids were 84.9% identical. Phylogenetic analyses showed that ECHO30 in the Zhejiang area has diverged into two genotypes. Genotype I consists of strains isolated since 2002, whereas genotype II includes strains that were mainly isolated during the 2002 to 2004 outbreak. ECHO30 has been endemically circulating in both humans and the environment for a long period of time. Additionally, we evaluated the significance of recombination presented during the years 2005 to 2007 to demonstrate that recombination plays an important role in the prevalence of ECHO30 in the Zhejiang area.

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Section: Discussionmentioning

confidence: 79%

Molecular Epidemiology and Prevalence of Echovirus 30 in Zhejiang Province, China, from 2002 to 2015

Chen

Sun

Yan

et al. 2017

Journal of Microbiology and Biotechnology

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“…Using our sequencing data, we were able to successfully conduct a phylodynamic analysis on both the VP1 and 3D pol regions. The division of lineages into geographically or globally distributed tracts has also been reported in several other enteroviruses [ 38 , 39 ]. The analysis of VP1 revealed a stair-like (unbalanced) topology, which has also been observed in several other phylogenic investigations of enterovirus strains [ 13 , 40 ].…”

Section: Discussionmentioning

confidence: 76%

Transmission and Demographic Dynamics of Coxsackievirus B1

et al. 2015

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The infectious activity of coxsackievirus B1 (CV-B1) in Taiwan was high from 2008 to 2010, following an alarming increase in severe neonate disease in the United States (US). To examine the relationship between CV-B1 strains isolated in Taiwan and those from other parts of the world, we performed a phylodynamic study using VP1 and partial 3Dpol (414 nt) sequences from 22 strains of CV-B1 isolated in Taiwan (1989–2010) and compared them to sequences from strains isolated worldwide. Phylogenetic trees were constructed by neighbor-joining, maximum likelihood, and Bayesian Monte Carlo Markov Chain methods. Four genotypes (GI–IV) in the VP1 region of CV-B1 and three genotypes (GA–C) in the 3Dpol region of enterovirus B were identified and had high support values. The phylogenetic analysis indicates that the GI and GIII strains in VP1 were geographically distributed in Taiwan (1993–1994) and in India (2007–2009). On the other hand, the GII and GIV strains appear to have a wider spatiotemporal distribution and ladder-like topology A stair-like phylogeny was observed in the VP1 region indicating that the phylogeny of the virus may be affected by different selection pressures in the specified regions. Further, most of the GI and GII strains in the VP1 tree were clustered together in GA in the 3D tree, while the GIV strains diverged into GB and GC. Taken together, these data provide important insights into the population dynamics of CV-B1 and indicate that incongruencies in specific gene regions may contribute to spatiotemporal patterns of epidemicity for this virus.

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“…The present study provides phylogenetic evidence of earlier hypotheses suggesting that different lineages of a given EV type may have different transmission features and geographic distributions. The EV type E-30 genogroup VI (defined by Ke et al [ 52 ], also designated lineages d to h in [ 53 ]) has been reported in multiple worldwide outbreaks of acute meningitis over the last 15 years, in contrast to the re-emerging genogroup III (lineage a), which exhibited ‘endemic features’ in Russia [ 54 ]. Similar observations were derived from molecular epidemiology studies of two other infrequent EV types, E-3 and CV-B1.…”

Section: Discussionmentioning

confidence: 99%

Enterovirus Migration Patterns between France and Tunisia

et al. 2015

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The enterovirus (EV) types echovirus (E-) 5, E-9, and E-18, and coxsackievirus (CV-) A9 are infrequently reported in human diseases and their epidemiologic features are poorly defined. Virus transmission patterns between countries have been estimated with phylogenetic data derived from the 1D/VP1 and 3CD gene sequences of a sample of 74 strains obtained in France (2000–2012) and Tunisia (2011–2013) and from the publicly available sequences. The EV types (E-5, E-9, and E-18) exhibited a lower worldwide genetic diversity (respective number of genogroups: 4, 5, and 3) in comparison to CV-A9 (n = 10). The phylogenetic trees estimated with both 1D/VP1 and 3CD sequence data showed variations in the number of co-circulating lineages over the last 20 years among the four EV types. Despite the low number of genogroups in E-18, the virus exhibited the highest number of recombinant 3CD lineages (n = 10) versus 4 (E-5) to 8 (E-9). The phylogenies provided evidence of multiple transportation events between France and Tunisia involving E-5, E-9, E-18, and CV-A9 strains. Virus spread events between France and 17 other countries in five continents had high probabilities of occurrence as those between Tunisia and two European countries other than France. All transportation events were supported by BF values > 10. Inferring the source of virus transmission from phylogenetic data may provide insights into the patterns of sporadic and epidemic diseases caused by EVs.

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Molecular epidemiology of Echovirus 30 in Taiwan, 1988–2008

Cited by 7 publications

References 40 publications

Molecular Epidemiology and Prevalence of Echovirus 30 in Zhejiang Province, China, from 2002 to 2015

Molecular Epidemiology and Prevalence of Echovirus 30 in Zhejiang Province, China, from 2002 to 2015

Transmission and Demographic Dynamics of Coxsackievirus B1

Enterovirus Migration Patterns between France and Tunisia

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