Molecular Epidemiology of Acute Gastroenteritis Caused by Subgenus F (40, 41) Enteric Adenoviruses in Inpatient Children

Rezaei, Maryam; Sohrabi, Amir; Edalat, Rosita; Siadat, Seyed Davar; Gomari, Hosna; Rezaei, Marziyeh; Gilani, Shahab Modarres

doi:10.1309/lmjg3uebibwbjph4

Cited by 14 publications

(14 citation statements)

References 23 publications

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“…We found HAdV in around 5% of children with acute gastroenteritis. Our findings were consistent with the detection rate of HAdV among acute gastroenteritis cases in earlier studies in Iran and other countries, which ranged from 2% to 9% and 1% to 31%, respectively. Three species and five types of HAdV were detected to be circulating during the study period.…”

Section: Discussionsupporting

confidence: 92%

Section: Introductionsupporting

confidence: 85%

“…In Iran, previous studies from 2002 to 2016 have been reported the prevalence of HAdV ranging from 2% to 9% among children, while AdV‐40 and AdV‐41 have been the most predominantly reported circulating types . Moreover, few reports have shown that AdV‐41 was the dominant type associated with acute gastroenteritis among children, which were similar to the findings of other studies . Considering rotavirus vaccine introduction as a high priority in the future years for countries like Iran, as well as the limited studies on the detection and genetic analysis of HAdVs associated with acute gastroenteritis, it is crucial to provide exact epidemiological data on main circulating viruses such as HAdVs causing gastroenteritis in Iranian children.…”

Section: Introductionsupporting

confidence: 81%

“…The HAdV‐41 was the most predominant, followed by HAdV‐1, HAdV‐2, HAdV‐3, and HAdV‐6. Previous studies in Iran have demonstrated that HAdV‐40 and 41 were the only types found in children with gastroenteritis, while present study indicated the existence of “non‐EAdV” types 1, 2, 3, and 6, which might be responsible for gastroenteritis, and have also been reported frequently in other countries . However, coinfections with other acute gastroenteritis infectious agents cannot be ruled out in this case.…”

Section: Discussioncontrasting

confidence: 45%

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Molecular analysis of human adenoviruses in hospitalized children <5 years old with acute gastroenteritis in Tehran, Iran

Arashkia

Bahrami

Farsi

et al. 2019

Journal of Medical Virology

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Human adenoviruses (HAdVs), especially AdV-40 and 41, are common causes of nonbacterial sporadic and outbreak gastroenteritis in children. The present study aimed to describe the frequency and genetic analysis of HAdVs in hospitalized children <5 years old with acute gastroenteritis. A total of 376 stool samples obtained from June 2015 to December 2017 were investigated for the presence of HAdVs by polymerase chain reaction. The HAdV DNA was detected in 16 (4.3%) out of 376 stool samples. Based on the hexon hypervariable region (HVR), B, C, and F HADV species including five types HAdV-1, 2, 3, 6, and 41 were identified, among which enteric AdV species F (EAdV-41) was the most dominant. Moreover, our findingsshowed the presence of genomic type cluster 1 (GTC1) pattern in Iranian type 41 strains, which was closely similar to the D1 prototype strain (Tak) and D28. In this regard, a recombination was found in AdV-41 strains presenting the hexon sequence that belonged to GTC1, while fiber sequence clustered with GTC2.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionsupporting

confidence: 85%

Section: Introductionsupporting

confidence: 81%

Section: Discussioncontrasting

confidence: 45%

See 2 more Smart Citations

Molecular analysis of human adenoviruses in hospitalized children <5 years old with acute gastroenteritis in Tehran, Iran

Arashkia

Bahrami

Farsi

et al. 2019

Journal of Medical Virology

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“…These tests are highly specific and sensitive as compared to traditional diagnostics. PCR, RT-PCR [45,46]. Fluorescence in situ hybridization, loop-mediated isothermal amplification, microarray analysis and Q-PCR [47,48] is used in molecular biological assays [49].…”

Section: Conventional Methods For Isolation Of Causative Organismsmentioning

confidence: 99%

Eco-Epidemiology and Control of Waterborne Gastroenteritis: A Review

A¹

2015

J Food Process Technol

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Viral and bacterial pathogens appear to be the causative agents of water-borne gastroenteritis globally. Waterborne gastroenteritis is the primary cause of loss of productivity and morbidity in developed and underdeveloped nations. Lack of extensive epidemiological surveillance and data analysis of viral and bacterial waterborne gastroenteritis is a major hindrance in the control of this disease. The burden of gastroenteritis is highest in the children and immunocompromised persons as compared to the elderly population. Essentially, Rotavirus, Norovirus, Pestivirus, Escherichia coli, Listeria monocytogenese, Yersinia pestis, Clostridium difficile, Vibrio cholerae, Aeromonashydrophila are primary causative organisms of waterborne gastroenteritis globally. This review highlights the current knowledge of waterborne pathogens and their significance, epidemiological factors like worldwide prevalence, hosts, causative agents, associated risk factors, clinical signs and symptoms, conventional as well as molecular diagnostic tools to combat the disease and recent approaches to effective treatments and new innovative methods of controlling these infectious agents that cause gastroenteritis will be discussed.

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Genetic characterization and phylogenetic variations of human adenovirus‐F strains circulating in eastern India during 2017–2020

Chandra

Mitra

et al. 2021

Journal of Medical Virology

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Human adenovirus-F (HAdV-F) (genotype 40/41) is the second-most leading cause of pediatric gastroenteritis after rotavirus, worldwide, accounting for 2.8%-11.8% of infantile diarrheal cases. Earlier studies across eastern India revealed a shift in the predominance of genotypes from HAdV41 in 2007-09 to HAdV40 in 2013-14.Thus, the surveillance for HAdV-F genotypes in this geographical setting was undertaken over 2017-2020 to analyze the viral evolutionary dynamics. A total of 3882 stool samples collected from children (≤5 years) were screened for HAdV-F positivity by conventional PCR. The hypervariable regions of the hexon and the partial shaft region of long fiber genes were amplified, sequenced, and phylogenetically analyzed with respect to the prototype strains. A marginal decrease in enteric HAdV prevalence was observed (9.04%, n = 351/3882) compared to the previous report (11.8%) in this endemic setting. Children <2 years were found most vulnerable to enteric HAdV infection. Reduction in adenovirus-rotavirus coinfection was evident compared to the sole adenovirus infection. HAdV-F genotypes 40 and 41 were found to co-circulate, but HAdV41 was predominant. HAdV40 strains were genetically conserved, whereas HAdV41 strains accumulated new mutations. On the basis of a different set of mutations in their genome, HAdV41 strains segregated into 2 genome type clusters (GTCs). Circulating HAdV41 strains clustered with GTC1 of the fiber gene, for the first time during this study period. This study will provide much-needed baseline data on the emergence and circulation of HAdV40/41 strains for future vaccine development.

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Molecular Epidemiology of Acute Gastroenteritis Caused by Subgenus F (40, 41) Enteric Adenoviruses in Inpatient Children

Cited by 14 publications

References 23 publications

Molecular analysis of human adenoviruses in hospitalized children <5 years old with acute gastroenteritis in Tehran, Iran

Molecular analysis of human adenoviruses in hospitalized children <5 years old with acute gastroenteritis in Tehran, Iran

Eco-Epidemiology and Control of Waterborne Gastroenteritis: A Review

Genetic characterization and phylogenetic variations of human adenovirus‐F strains circulating in eastern India during 2017–2020

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