Molecular analysis of human adenoviruses in hospitalized children &lt;5 years old with acute gastroenteritis in Tehran, Iran

Arashkia, Arash; Bahrami, Ferial; Farsi, Mahsa; Nejati, Behrooz; Jalilvand, Somayeh; Nateghian, Alireza; Rahbarimanesh, A A; Shoja, Zabihollah

doi:10.1002/jmv.25539

Cited by 14 publications

(7 citation statements)

References 53 publications

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“…This AdV41 had been reported from children acute gastroenteritis in previous studies of India, Thailand, Iraq, and many other countries. AdV5, AdV7, and AdV8 had also been reported from nearby countries of Bangladesh 1,36,37 . Our study found AdV41 was the most prevalent in children stool samples which is in agreement with previous studies of India, Thailand, and Iraq 38,39 …”

Section: Discussionsupporting

confidence: 92%

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Molecular and epidemiological trends of human bocavirus and adenovirus in children with acute gastroenteritis in Bangladesh during 2015 to 2019

Sharif

Parvez

Haque

et al. 2020

Journal of Medical Virology

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Virus associated diarrhea remains one of the leading causes of children morbidity and mortality in Bangladesh. Human bocavirus (HBoV) has been reported as a potential pathogen of children's diarrhea worldwide. However, due to its frequent association with other gastroenteric pathogens, its role as diarrhea causative agent remains to be defined. This study focuses to detect the incidence of HBoV and adenovirus (AdV) and to determine the molecular and epidemiological characteristics of HBoV and AdV. Between January 2015 to January 2019, 290 fecal specimens were collected from diarrheal children in Bangladesh. All fecal specimens were tested for HBoV and AdV by conventional polymerase chain reaction and sequencing methods. HBoV was detected in 7.24% (21 of 290) of the stool samples, as a sole virus in 71.42% (15 of 21) of the positive samples. AdV was detected in 4.82% (14 of 290) of the samples. The most common clinical symptoms of HBoV infected patients were diarrhea (100%) and vomiting (57%). All of the isolates of HBoV were from HBoV1 and AdV were from AdV41, AdV5, AdV7, and AdV8. To the best of our knowledge, this is the first epidemiological and molecular analysis report of HBoV from clinical specimens in Bangladesh. In the future, more studies are needed to clarify the role of HBoV as diarrheal pathogens.

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Section: Discussionsupporting

confidence: 92%

“…AdV5, AdV7, and AdV8 had also been reported from nearby countries of Bangladesh. 1,36,37 Our study found AdV41 was the most prevalent in children stool samples which is in agreement with previous studies of India, Thailand, and Iraq. 38,39 In this study, most of the infants and children with AdV infection (64%) were aged less than 24 months.…”

Section: Discussionsupporting

confidence: 92%

Molecular and epidemiological trends of human bocavirus and adenovirus in children with acute gastroenteritis in Bangladesh during 2015 to 2019

Sharif

Parvez

Haque

et al. 2020

Journal of Medical Virology

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“…Infectious agents, particularly viruses are the main cause of GE worldwide ( 2 ). Before the implication of Rotavirus vaccination, Rotavirus was the leading cause of viral GE, while other enteric viruses, such as Noroviruses, Astroviruses, and Human adenoviruses, are now the most prevalent viruses causing GE ( 3 ). Besides the aforementioned enteric viruses, the list of enteric viruses is continuously growing due to the discovery of emerging viruses ( 4 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

Global Status of Bufavirus, Cosavirus, and Saffold Virus in Gastroenteritis: A Systematic Review and Meta-Analysis

2022

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Background: Bufavirus (BuV), Human Cosavirus (HCoSV), and Saffold (SAFV) virus are three newly discovered viruses and have been suggested as possible causes of gastroenteritis (GE) in some studies. The aim of the present study was to estimate the overall prevalence of viruses and their association with GE.Methods: A comprehensive systematic search was conducted in Scopus, Web of Science, PubMed, and Google scholar between 2007 and 2021 to find studies on the prevalence of BuV, HCoSV, and SAFV viruses.Result: Meta-analysis of the 46 included studies showed the low prevalence of BuV (1.%, 95% CI 0.6–1.5%), HCoSV (0.8%, 95% CI 0.4–1.5%), and SAFV (1.9%, 95% CI 1.1–3.1%) worldwide. Also, no significant association between these viruses and GE was observed. BuV was isolated from patients with GE in Africa, while SAFV was more common in Europe. BuV1 and BuV2 have the same prevalence between the three identified genotypes of BuV. HCoSV-C was the most prevalent genotype of HCoSV, and SAFV2 was the commonest genotype of SAFV. All of these viruses were more prevalent in children older than 5 years of age.Conclusion: This was the first meta-analysis on the prevalence and association of BuV, HCoSV, and SAFV with GE. While no significant association was found between infection with these viruses and GE, we suggest more studies, especially with case-control design and from different geographical regions in order to enhance our knowledge of these viruses.

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“…Species F is primarily associated with gastroenteric disorders. Initial epidemiological studies on the prevalence of HAdV-40 and HAdV-41 reported that the occurrence rates of these genotypes were approximately equal [51]. However, the pattern of occurrence of these genotypes has changed in recent years, with a reduction in HAdV-40 and an increase of HAdV-41.…”

Section: Discussionmentioning

confidence: 99%

Detection and molecular characterization of enteric adenovirus in treated wastewater in the Brazilian Federal District

et al. 2021

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Human enteric viruses, such as enteric adenoviruses (HAdV), are known to be involved with gastrointestinal disorders, especially acute gastroenteritis. Several studies have used HAdV as an indicator of water quality, since they are considered highly stable and widely distributed viruses in water matrices. The aim of this study was to detect and genotype HAdVs in water matrices impacted by discharges of treated effluents from wastewater treatment plants (WWTPs). Wastewater treatment plants from the sanitary system of the Brazilian Federal District were assessed in 2018 and 2019. Samples were collected upstream and downstream from discharge points for each WWTP. Viral concentration based on adsorption-elution and conventional PCR was used for molecular detection, and positive samples were sequenced for phylogenetic analysis. Pluviosity data for the period in which the samples were collected were obtained. Our results demonstrated the presence of HAdVs in 27.2% (61/224) of the samples. The positivity was significantly higher in downstream samples compared to upstream. Moreover, the HAdV positivity was higher in downstream samples collected from receiving water bodies impacted by secondary-level WWTPs in comparison with those impacted by tertiary-level WWTPs. Phylogenetic analysis demonstrated the presence of genotypes 40 and 41, with prevalence of HAdV genotype 41. Despite the predominance of HAdV-41, an increasing frequency of the HAdV-40 was associated with higher pluviosity. In conclusion, this study is the first documentation in the Brazilian Federal District dealing with the prevalence and diversity of HAdVs in several WWTP, along with their correlation with rainfall index.

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Molecular analysis of human adenoviruses in hospitalized children <5 years old with acute gastroenteritis in Tehran, Iran

Cited by 14 publications

References 53 publications

Molecular and epidemiological trends of human bocavirus and adenovirus in children with acute gastroenteritis in Bangladesh during 2015 to 2019

Molecular and epidemiological trends of human bocavirus and adenovirus in children with acute gastroenteritis in Bangladesh during 2015 to 2019

Global Status of Bufavirus, Cosavirus, and Saffold Virus in Gastroenteritis: A Systematic Review and Meta-Analysis

Detection and molecular characterization of enteric adenovirus in treated wastewater in the Brazilian Federal District

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