Molecular Epidemiology Features of HBV/HDV Co-Infection in Kyrgyzstan

Семенов, А В; Владимировна, Останкова Юлия; Ногойбаева, К.А.; Касымбекова, К. Т.; Лаврентьева, И. Н.; Тобокалова, С. Т.; Тотолян, Арег А.

doi:10.15789/2220-7619-2016-2-141-150

Cited by 9 publications

(6 citation statements)

References 28 publications

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“…Fragmentary studies suggested that Central Asia may also bear the brunt of hepatitis D, but these studies were usually published in the local press and went unnoticed by the global scientific community; so far the issue of hepatitis D in the area has not attracted international interest and was not comprehensively investigated …”

Section: Introductionmentioning

confidence: 99%

“…1 Despite the high endemicity of the HBV in Central Asia, the impact of HDV infection in this macro-area is largely unknown, in contrast to its major medical role in surrounding Iran, 2 Pakistan 3 and Mongolia. 4 Fragmentary studies suggested that Central Asia may also bear the brunt of hepatitis D, [5][6][7] but these studies were usually published in the local press and went unnoticed by the global scientific community; so far the issue of hepatitis D in the area has not attracted international interest and was not comprehensively investigated. 8 With a population of almost 32 million and an HBV prevalence of about 13%, 9 Uzbekistan is aggravated by the highest burden of hepatitis B surface antigen (HBsAg)-positive liver diseases in Central Asia.…”

Section: Introductionmentioning

confidence: 99%

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The medical impact of hepatitis D virus infection in Uzbekistan

Khodjaeva¹,

Ibadullaeva²,

Khikmatullaeva³

et al. 2019

Liver International

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Background & Aims The hepatitis B virus (HBV) is endemic in Uzbekistan but the medical impact of infection with the HBV‐dependent hepatitis D virus (HDV) is unknown in the Country. An Hepatology Center was recently established at the Institute of Virology in Tashkent, which has set up a database enlisting patients with chronic viral liver disorders from all over Uzbekistan; it provides an observatory on the current scenario of viral hepatitis in the Country. Methods The prevalence of HBV monoinfection, hepatitis C virus (HCV) infection and HDV superinfection on hepatitis B surface antigen (HBsAg)‐positive cirrhosis was determined in 6589 patients with viral cirrhosis collected in the last 3 years. Results Of 1089, 1150 and 1455 carriers of the HBsAg with cirrhosis recruited in 2016, 2017 and 2018, 834 (76.5%), 926 (80.5%) and 1224 (84%) respectively, had antibody to the HDV. In 2016, 2017 and 2018, the prevalence of HDV infection has been 41%, 45% and 49.1% respectively, largely exceeding the prevalence of HBV monoinfection (12.5%, 11% and 9.3% respectively) and surpassing the prevalence of HCV in 2017 and 2018 (44% and 41.5% respectively). The median age of the patients with HDV cirrhosis was 39 years, distinctly lower than that of HBV and HCV patients (46 and 55). Conclusions Superinfection with the HDV is present in over 80% of the HBsAg‐positive cirrhosis in Uzbekistan. The HDV appears to be the major cause of advanced viral liver disease and of juvenile cirrhosis in the Country.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The medical impact of hepatitis D virus infection in Uzbekistan

Khodjaeva¹,

Ibadullaeva²,

Khikmatullaeva³

et al. 2019

Liver International

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“…Kyrgyzstan is one of the WHO’s viral hepatitis focus countries; however, the country’s situation in terms of HBV and HCV prevalence is unknown due to the absence of population-based nationally representative studies [ 48 ]. A study conducted on thirty plasmas collected from chronic HBV and HDV patients across Kyrgyzstan [ 49 ] revealed that by using phylogenetic analysis that all of the included patients were HBV genotype D and dominated by HBV subtype D1 (73.34%). HDV genotype I was also identified with a highly variable delta antigen coding region [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

“…A study conducted on thirty plasmas collected from chronic HBV and HDV patients across Kyrgyzstan [ 49 ] revealed that by using phylogenetic analysis that all of the included patients were HBV genotype D and dominated by HBV subtype D1 (73.34%). HDV genotype I was also identified with a highly variable delta antigen coding region [ 49 ]. Importantly, this report suggested the occurrence of several independent genetic drifts in HDV strains into the territory of Kyrgyzstan with a high speed of HDV evolution in the region [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Global Distribution and Natural Recombination of Hepatitis D Virus: Implication of Kyrgyzstan Emerging HDVs in the Clinical Outcomes

Bahoussi

Wang²,

Guo³

et al. 2022

Viruses

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Discrepancies in human hepatitis delta virus (HDV) genotypes impact the virus’ biological behavior, clinical manifestation, and treatment response. Herein, this report aims to explore the role of recombination in the worldwide genotypic distribution and genetic diversity of HDV. Three-hundred-forty-eight human HDV full-length genomic sequences of ~1678 nt in length, isolated in twenty-eight countries worldwide between 1986 and 2018, were analysed. Similarity analysis and recombination mapping were performed, and forty-eight recombination events were identified, twenty-nine of which were isolated from Kyrgyzstan and determined to be involved in the diversity and extension of HDV sub-genotypes. HDV recombination occurred only between the genetically close genotypes (genotype 5 and genotype 2) or mainly within genotype 1, suggesting the complex replicative molecular mechanisms of HDV-RNA. The global distribution and classification of HDV genotypes have been updated, indicating that HDV recombination is one of the driving forces behind the biodiversity and the evolution of human HDV genomes. The outcome analysis suggests that the expansion of HDV sub-genotypes and the complex recombination networks might be related to the genomic character of Kyrgyzstan circulating strains and extensive mobility within countries and across borders. These findings will be of great importance in formulating more effective public health HDV surveillance strategies and guiding future molecular and epidemiological research to achieve better clinical outcomes.

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“…The data by Khodjaeva et al represent an important contribution to the epidemiology of HDV in a geographical region that has been historically overlooked. Data on the prevalence and health burden of hepatitis D from Central Asia are scarce, with reports often published in Russian, and thus of difficult access to the Western public . It is encouraging to observe the increasing number of studies focusing on liver disease burden in Uzbekistan, especially promoted by the team at the Tashkent Research Institute of Virology.…”

mentioning

confidence: 99%