Molecular Epidemiology and Phylogenetic Analyses of Influenza B Virus in Thailand during 2010 to 2014

Tewawong, Nipaporn; Suwannakarn, Kamol; Prachayangprecha, Slinporn; Korkong, Sumeth; Vichiwattana, Preeyaporn; Vongpunsawad, Sompong; Poovorawan, Yong

doi:10.1371/journal.pone.0116302

Cited by 43 publications

(58 citation statements)

References 41 publications

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“…Thirteen relevant articles were identified for Thailand that reported for seasons between 1998 and 2014. One large laboratory‐based surveillance study detected influenza viruses in 18.4%‐25.5% of samples collected from patients with ILI between 2007 and 2011 . The percentages of influenza‐positive samples that were influenza B ranged from 12.9% in 2009 to 42.9% in 2008 …”

Section: Resultsmentioning

confidence: 99%

Literature review of the epidemiology of influenza B disease in 15 countries in the Asia‐Pacific region

Jennings

Huang

Barr

et al. 2018

Influenza Resp Viruses

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Influenza control strategies focus on the use of trivalent influenza vaccines containing two influenza A virus subtypes and one of the two circulating influenza type B lineages (Yamagata or Victoria). Mismatches between the vaccine B lineage and the circulating lineage have been regularly documented in many countries, including those in the Asia‐Pacific region. We conducted a literature review with the aim of understanding the relative circulation of influenza B viruses in Asia‐Pacific countries. PubMed and Western Pacific Region Index Medicus were searched for relevant articles on influenza type B published since 1990 in English language for 15 Asia‐Pacific countries. Gray literature was also accessed. From 4834 articles identified, 121 full‐text articles were analyzed. Influenza was reported as an important cause of morbidity in the Asia‐Pacific region, affecting all age groups. In all 15 countries, influenza B was identified and associated with between 0% and 92% of laboratory‐confirmed influenza cases in any one season/year. Influenza type B appeared to cause more illness in children aged between 1 and 10 years than in other age groups. Epidemiological data for the two circulating influenza type B lineages remain limited in several countries in the Asia‐Pacific, although the co‐circulation of both lineages was seen in countries where strain surveillance data were available. Mismatches between circulating B lineages and vaccine strains were observed in all countries with available data. The data suggest that a shift from trivalent to quadrivalent seasonal influenza vaccines could provide additional benefits by providing broader protection.

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Section: Resultsmentioning

confidence: 99%

Literature review of the epidemiology of influenza B disease in 15 countries in the Asia‐Pacific region

Jennings

Huang

Barr

et al. 2018

Influenza Resp Viruses

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“…Globally, influenza A viruses are more frequently incriminated in flu epidemics as compared with influenza B viruses. However, influenza B viruses are accountable for the non‐negligible burden of the disease worldwide, especially in children …”

Section: Introductionmentioning

confidence: 99%

Genetic characterization of influenza B virus in Cameroon and high frequency of reassortant strains

Monamele

Vernet

Njankouo

et al. 2018

Journal of Medical Virology

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Influenza B is broadly divided into B/Victoria and B/Yamagata lineages based on its genetic and antigenic properties. We describe in this study the first report on genome characterization of type B influenza virus in the Cameroon National Influenza Center (NIC) between 2014 and 2017. Respiratory samples were collected as part of the influenza surveillance activity in the NIC. RNA products were tested for the presence of influenza using the CDC Influenza A/B typing panel. Thirty-five samples positive for influenza B were selected for sequencing three gene segments (HA, NA, and M) and phylogenetic trees were generated by MEGA version 6.0. Nucleotide phylogenetic analysis of the HA gene revealed the presence of three major clades among Cameroonian strains. All Victoria lineages grouped into B/Victoria clade 1A, while, Yamagata lineages grouped into Yamagata clade 2 (2014 strains) and Yamagata clade 3 (2015-2017). We observed a high frequency of reassortant viruses with Yamagata-like HA gene and Victoria-like NA gene (27.4%; 23/84). The results from this study confirm variations in the genome composition of type B influenza virus and emphasize on the relevance of molecular surveillance for spotting peculiar genetic variants of public health and clinical significance.

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“…Influenza B‐confirmed ARI samples were genotyped by Haemagglutinin ( HA ) gene sequencing using BigDye Terminator ver.3.1 cycle sequencing kit (Applied Biosystem, Foster City, CA, USA) with 3730 DNA Analyzer (Applied Biosystem, Foster City, CA, USA). Influenza B reference sequences including WHO recommended vaccine strains for northern hemisphere from 2007 to 2014 (https://www.who.int/influenza/vaccines/virus/recommendations/en/) were obtained from GenBank (http://www.ncbi.nlm.nih.gov/genbank/) and EpiFlu database within Global Initiative on Sharing All Influenza Data (GISAID)(http://platform.gisaid.org) and included in phylogenetic analysis as previously described . These reference strains were used in order to further classify lineage into groups based on Worldwide Influenza Centre (WIC) (https://www.crick.ac.uk/partnerships/worldwide-influenza-centre).…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies from Cambodia, China, India, and Taiwan have reported the increase of influenza B‐associated ARI cases in the following seasons after the emergence of the pandemic A/H1N1pdm09 strain . Furthermore, some studies presented the circulation of Victoria lineage as a dominant type in the post‐A/H1N1pdm09 period, whereas others showed co‐circulation of both lineages . Regardless of a few epidemiological studies on influenza B lineage‐specific clinical presentation, the clinical aspect of two genetically distinct lineages has not been clearly understood up to date.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, some studies presented the circulation of Victoria lineage as a dominant type in the post‐A/H1N1pdm09 period, whereas others showed co‐circulation of both lineages . Regardless of a few epidemiological studies on influenza B lineage‐specific clinical presentation, the clinical aspect of two genetically distinct lineages has not been clearly understood up to date.…”

Section: Introductionmentioning

confidence: 99%

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Influenza B associated paediatric acute respiratory infection hospitalization in central vietnam

Yoshihara

Toizumi

et al. 2019

Influenza Resp Viruses

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Background Influenza B is one of the major etiologies for acute respiratory infections ( ARI ) among children worldwide; however, its clinical‐epidemiological information is limited. We aimed to investigate the hospitalization incidence and clinical‐epidemiological characteristics of influenza B‐associated paediatric ARI s in central Vietnam. Methods We collected clinical‐epidemiological information and nasopharyngeal swabs from ARI children hospitalized at Khanh Hoa General Hospital, Nha Trang, Vietnam from February 2007 through June 2013. Nasopharyngeal samples were screened for 13 respiratory viruses using Multiplex‐ PCR s. Influenza B‐confirmed cases were genotyped by Haemagglutinin gene sequencing. We analyzed the clinical‐epidemiological characteristics of influenza B Lineages (Victoria/Yamagata) and WHO Groups. Results In the pre‐A/H1N1pdm09 period, influenza B‐associated ARI hospitalization incidence among children under five was low, ranging between 14.7 and 80.7 per 100 000 population. The incidence increased to between 51.4 and 330 in the post‐A/H1N1pdm09. Influenza B ARI cases were slightly older with milder symptoms. Both Victoria and Yamagata lineages were detected before the A/H1N1pdm09 outbreak; however, Victoria lineage became predominant in 2010‐2013 (84% Victoria vs 16% Yamagata). Victoria and Yamagata lineages did not differ in demographic and clinical characteristics. In Victoria lineage, Group1 ARI cases were clinically more severe compared to Group5, presenting a greater proportion of wheeze, tachypnea, and lower respiratory tract infection. Conclusions The current results highlight the increased incidence of influenza B‐related ARI hospitalization among children in central Vietnam in the post‐A/H1N1pdm09 era. Furthermore, the difference in clinical severity between Victoria lineage Group1 and 5 implies the importance of influenza B genetic variation on clinical presentation.

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Molecular Epidemiology and Phylogenetic Analyses of Influenza B Virus in Thailand during 2010 to 2014

Cited by 43 publications

References 41 publications

Literature review of the epidemiology of influenza B disease in 15 countries in the Asia‐Pacific region

Literature review of the epidemiology of influenza B disease in 15 countries in the Asia‐Pacific region

Genetic characterization of influenza B virus in Cameroon and high frequency of reassortant strains

Influenza B associated paediatric acute respiratory infection hospitalization in central vietnam

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