Molecular epidemiology and clinical features of Hepatitis C Virus(HCV) in epidemic areas of Interior Sindh, Pakistan

Bhatti, Shameem; Manzoor, Sobia

doi:10.12669/pjms.325.10429

Cited by 8 publications

(7 citation statements)

References 14 publications

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“…HCV genotyping data of Sindhi patients published in 2014 resemble our findings (12). These analyses demonstrate 3a as most prevalent genotype, followed by untypable, 3b, and 1a in decreasing order (12,24). Conclusions drawn by Shaikh et al were in contrast with the analysis in this study, which showed 3a (50.8%) as most prevalent, and exceptionally high frequency of untypable (47%) was observed, followed by 2a (1.6%).…”

Section: Hcv Genotype Prevalence In Pakistan 409contrasting

confidence: 96%

Prevalence of Hepatitis C Virus Genotypes in Pakistan: Current Scenario and Review of Literature

Haqqi

Munir

Khalid³

et al. 2019

Viral Immunology

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Hepatitis C virus (HCV) is a major public health concern globally, resulting in liver-related complications. Approximately 6% population of Pakistan is infected with HCV. HCV is error prone, due to which it is classified into 7 genotypes and 67 subtypes. HCV genotype determination is critical for treatment and therapy response. In this study, 3,539 samples were collected from 2015 to 2019 from all over Punjab. RNA was extracted from samples using QIA Amp Viral RNA MINI kit (Qiagen, Germany) and viral genotyping was performed. Furthermore, a systemized literature search (2009-2018) was done to analyze the HCV genotype distribution pattern in Pakistan. In Punjab, genotype 3a (86.46%) is most prevalent, followed by untypable (7.17%) and genotype 1a (3.84%) and 3b (1.04%). Mixed genotype constitutes only 0.67% of total infections. Genotype 2a, 2b, 3c, and 4 were found to be rare. Data available from literature review when compiled showed that HCV genotype 3a (58.16%) was predominant in Pakistan, followed by genotypes 3b (9.05%), 2a (6.70%), 1a (6.22%), and 1b (2.39%). The frequency of mixed genotypes was found to be 4% and 12% of untypable HCV variants. This study highlights the HCV genotype distribution pattern in different regions of Pakistan. Therapy response and disease management depend on genotype, so HCV genotype determination is crucial. In Pakistan, the most prevalent genotype is 3a, followed by untypable genotype. Both interferon and sofosbuvir are effective against genotype 3a, but treatment with sofosbuvir has comparatively high sustained virological response, less adverse effects, and more tolerability.

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Section: Hcv Genotype Prevalence In Pakistan 409contrasting

confidence: 96%

Prevalence of Hepatitis C Virus Genotypes in Pakistan: Current Scenario and Review of Literature

Haqqi

Munir

Khalid³

et al. 2019

Viral Immunology

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“…Manzor 2016 reported higher prevalence of Hepatitis C among males as compared to females with the age range from 18 to 65 years (Bhatti and Manzoor 2016).…”

Section: Resultsmentioning

confidence: 99%

Frequency of Hepatitis B and C in Relation to Lifestyle and Socio-Demographic Characteristics Among Adults in Lahore

Raza¹,

Khan²,

Fatima³

et al. 2022

Preprint

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Hepatitis is the eighth highest cause of mortality globally and second-highest in Pakistan. The purpose of this study was to determine frequency of Hepatitis B and C and related lifestyle and socio-demographic risk factors among adults. The data were collected though questionnaire from Hepatitis B and C patients from Mayo and Jinnah hospital Lahore. The data was analyzed using SPSS version 18. There were 5095 patients with Hepatitis B and C out of which 146 patients (67 males and 79 females) filled questionnaire. The frequency of hepatitis C was higher than hepatitis B. The significant risk factors associated with hepatitis B and C were education, marital status, family history, household income, and type of food consumed. Therefore, socio-demographic and lifestyle risk factors related interventions are needed to reduce frequency of Hepatitis B and C.

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“…A few studies conducted in Karachi show dual HBV-HCV prevalence as 0.11% in household children26, 1.3% in viral hepatitis patients27 and 3.1% in patients of hepatitis B28. In one community based study Bhatti and Manzoor described 2.5% dual HBV-HCV prevalence in rural areas of Sindh29. A previous study by Junejo et al presented 3.9% co-prevalence of HBsAg and anti-HCV infection in the ocular patients of Hyderabad30.…”

Section: Introductionmentioning

confidence: 96%

Molecular surveillance of HCV mono-infection and HCV-HBV co-infection in symptomatic population at Hyderabad, Pakistan

Patoli

Balani

et al. 2018

Afr H. Sci.

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BackgroundPakistan is endemic to hepatitis B and C infections. Alarming rise in hepatitis C virus (HCV) infection has been noticed in some areas of Sindh with an increasing risk for co-infection frequency in this region.ObjectiveTo estimate the burden of HBV/HCV infection in Hyderabad Pakistan.MethodsELISA and Nucleic acid Amplification test were performed to detect viruses. SPSS and online calculator were used for statistical analysis.ResultsFrom a total of 108 seropositive hepatitis patients, 36.1% (n=39) were found HCV RNA-positive. Non-significant differences were observed in the frequencies of HCV infection for both genders [OR=0.735, CI (95%) 0.307–1.761, p<0.05]. The percentage of HBV DNA detection among 108 HCV-seropositive cases was 17.9% (n=19). However, HCV-HBV co-infection in HCV-RNA positive cases was determined in 48.7% (n=19) cases with non-significant difference in both genders [OR=1.51, CI (95%) = 0.38 - 5.96, p< 0.05]. Analysis suggested weakly positive correlation between HCV mono-infection and HCV-HBV co-infection and age (r =0.184, and r =0.1231), respectively.ConclusionThe study demonstrates a high prevalence of HBV co-infection among active hepatitis C patients of Hyderabad.

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Molecular epidemiology and clinical features of Hepatitis C Virus(HCV) in epidemic areas of Interior Sindh, Pakistan

Cited by 8 publications

References 14 publications

Prevalence of Hepatitis C Virus Genotypes in Pakistan: Current Scenario and Review of Literature

Prevalence of Hepatitis C Virus Genotypes in Pakistan: Current Scenario and Review of Literature

Frequency of Hepatitis B and C in Relation to Lifestyle and Socio-Demographic Characteristics Among Adults in Lahore

Molecular surveillance of HCV mono-infection and HCV-HBV co-infection in symptomatic population at Hyderabad, Pakistan

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