Molecular docking, theoretical calculations and potentiometric studies of some azo phenols

El-Bindary, A.A.; Hussein, Mouayed A.; El-Boz, R.A.

doi:10.1016/j.molliq.2015.06.070

Cited by 18 publications

(5 citation statements)

References 35 publications

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“…Isopentyl alcohol (Fisher Corporation, USA) was used. ACDP and/or ATDP used in the present investigation was prepared according to the procedure described previously [41]. A stock 2 × 10 -3 M solution of ACDP and/or ATDP was prepared by dissolving an appropriate weight of the reagent in a minimum amount of pure ethanol and brought to 100 ml in a calibrated flask with ethanol.…”

Section: Reagentsmentioning

confidence: 99%

Solid Phase Extraction Utilization for Colorimetric Determination of Zinc in Waters, Food, Milk, and Biological Samples

S¹,

MN²,

AG³

2019

Int J Analyt Bioanalyt Methods

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A highly rapid, sensitive, and selective method for the determination of zinc based on the reaction of zinc(II) with 5-amino-2-(phenyldiazenyl)phenol (ACDP) and/or 5-amino-2-(ptolyldiazenyl)phenol (ATDP) and the solid phase extraction of the Zn(II)-ACDP and/or ATDP complex with Amberlite XAD-2000 was developed, in the presence of pH = 5.6 and 6.2 using ACDP and ATDP, respectively, and Triton X-114 medium. ACDP and/or ATDP reacts with zinc to form a violet complex with a molar ratio of 2:1 (ACDP and/or ATDP to zinc). This complex was enriched by the solid phase extraction with Amberlite XAD-2000. An enrichment factor of 500 was obtained by elution of the complex from the resin with a minimal amount of isopentyl alcohol (0.2 ml). In isopentyl alcohol medium, the molar absorptivity of the complex is 1.13 × 10 6 and 1.37 × 10 6 L/mol cm at 647 and 662 nm using ACDP and ATDP, respectively, against a reagent blank prepared in a similar way without zinc. Beer's law is obeyed in the range of 5.0-160 ng/ml in the measured solution. The relative standard deviation for 10 replicate samples of 50 ng/ml level is 1.26 and 1.47%, respectively. The detection and quantification limits reaches 1.5 and 4.7 ng/ml in the original samples. The presented procedure was successfully applied for determination of zinc content in real samples such as waters, food, milk, and biological samples with satisfactory results.

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Section: Reagentsmentioning

confidence: 99%

Solid Phase Extraction Utilization for Colorimetric Determination of Zinc in Waters, Food, Milk, and Biological Samples

S¹,

MN²,

AG³

2019

Int J Analyt Bioanalyt Methods

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“…As an aromatic amino molecule, aminophenol serves as a reliable source of diazonium salts needed for azo coupling reactions. It is frequently used to create mono‐azo dyes, which are marketed as coloring agents 4–8 . The kind of metal, its valence, the quantity of donor atoms in the ligand, the type of chelating ring formation, and the pH of the reaction medium are some of the variables that affect how much azo dye compounds coordinate with metal ions.…”

Section: Introductionmentioning

confidence: 99%

“…It is frequently used to create mono-azo dyes, which are marketed as coloring agents. [4][5][6][7][8] The kind…”

mentioning

confidence: 99%

Analyzing the structure of the metal complexes of biologically active azo dye ligand

Saleh,

El‐Sayed,

Zayed

et al. 2024

Applied Organom Chemis

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A novel azo dye ligand was created by diazotizing 4‐aminoantipyrine and then coupling it with 2‐aminophenol as part of a methodical investigation of physiologically active compounds, 4‐aminoantipyrine. The novel complexes containing Cr(III), Fe(III), Mn(II), Co(II), Ni(II), Zn(II), Cu(II), and Cd(II) were created from the target ligand (L). The structures of the ligand and metal complexes were verified by elemental analyses, thermogravimetric analysis–difference thermogravimetry (TGA‐DTG), conductivity measurements, infrared (IR), UV–Vis, 1H‐nuclear magnetic resonance (NMR), X‐ray diffraction (XRD), and mass spectrometry. Using the Gaussian 09 tool, the density functional theory (DFT)/B3LYP method was utilized to compute the energy gaps and other important theoretical features. Also, the newly synthesized azo dye ligand, in comparison with metal complexes, was screened for its antimicrobial activity. The crystal structures of Staphylococcus aureus and Bacillus subtilis as gram‐positive bacteria, Salmonella sp. and Escherichia coli as gram‐negative bacteria, and fungal (Aspergillus fumigatus and Candida albicans) species were compared with the produced azo dye and its metal complexes via molecular docking. Most of the complexes exhibited greater antimicrobial activities against these organisms than did the original azo dye ligand.

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“…Azo compounds are one of the most widely used chemical groups of organic compounds, with various applications [1] in advanced organic synthesis to high technology areas such as liquid crystalline displays, ink-jet printers, lasers, and electro optical devices [2]. They are also known to have wide ranges of biological effects such as DNA, RNA inhibition and protein synthesis, carcinogenesis, and nitrogen fixation [3].…”

Section: Introductionmentioning

confidence: 99%

New Azo-Schiff Compounds and Metal Complexes Derived from 2-Naphthol Synthesis, Characterization, Spectrophotometric, and Study of Biological Activity

Alabidi

Farhan²,

Salh

et al. 2022

Curr. Appl. Sci. Technol.

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This research involved synthesizing two compounds as derivatives of 2-naphthol by the classical method. The azo coupling compound was prepared via diazonium salt of 4-amino acetophenone followed by 2-naphthole. The azo-Schiff molecule was synthesized through condensation of an azo compound with 5-amino salicylic acid in an acidic medium. Using spectrum approaches, the new compounds are characterized (13C-NMR, 1H-NMR, FT-IR). The acid-base characteristics were investigated at various pH levels (0.67-12), and the ionization and protonation constants were determined. Spectroscopic methods were used to identify new copper (II), nickel (II), and cobalt (II) complexes of the azo-Schiff base ligand. All the compounds were evaluated for antibacterial activity against bacteria such as Staphylococcus aureus (Gram-positive bacteria) and Escherichia coli (Gram-negative bacteria). It was found that the coordination complexes of Cu and Co had an antibacterial effect on both concentrations against Staphylococcus aureus.

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Molecular docking, theoretical calculations and potentiometric studies of some azo phenols

Cited by 18 publications

References 35 publications

Solid Phase Extraction Utilization for Colorimetric Determination of Zinc in Waters, Food, Milk, and Biological Samples

Solid Phase Extraction Utilization for Colorimetric Determination of Zinc in Waters, Food, Milk, and Biological Samples

Analyzing the structure of the metal complexes of biologically active azo dye ligand

New Azo-Schiff Compounds and Metal Complexes Derived from 2-Naphthol Synthesis, Characterization, Spectrophotometric, and Study of Biological Activity

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