Molecular dissection of Porphyromonas gingivalis-related arteriosclerosis: a novel mechanism of vascular disease

Wada, Koichiro; Kamisaki, Yoshínori

doi:10.1111/j.1600-0757.2009.00336.x

Cited by 13 publications

(17 citation statements)

References 118 publications

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“…gingivalis has also been shown to modify LDL and promote phenotypic shift of monocytes to foam cells [75,77,88]. Our group has previously found fragmentation of the dominating apoprotein of LDL, apo B-100, by P. gingivalis and its Rgps [88].…”

Section: Periodontitis Systemic Inflammation and Cardiovascular Dismentioning

confidence: 85%

“…Several peri odontal bacteria and their agents have been identified in atherosclerotic plaques, for exam ple, P. gingivalis, Fusobacterium nucleatum, T. forsythia, Prevotella intermedia, Aggregatibacter actinomycetecomitans, and T. denticola [75][76][77][78]. The occurrence of periodontal bacteria in cor onary artery plaques was found to be 5-fold greater in patients with severe periodontitis compared to those with medium periodontitis [79], and DNA from periodontal bacteria, including P. gingivalis, was identified in more than 70% of carotid plaque samples [80].…”

Section: Periodontitis Systemic Inflammation and Cardiovascular Dismentioning

confidence: 99%

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Cellular Response Mechanisms in Porphyromonas gingivalis Infection

Khalaf¹,

Palm²,

Bengtsson³

2017

Periodontitis - A Useful Reference

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The pathogenicity of the periodontal biofilm is highly dependent on a few key species, of which Porphyromonas gingivalis is considered to be one of the most important pathogens.P. gingivalis expresses a broad range of virulence factors, of these cysteine proteases (gin gipains) are of special importance both for the bacterial survival/proliferation and for the pathological outcome. Several cell types, for example, epithelial cells, endothelial cells, dendritic cells, osteoblasts, and fibroblasts, reside in the periodontium and are part of the innate host response, as well as platelets, neutrophils, lymphocytes, and monocytes/mac rophages. These cells recognize and respond to P. gingivalis and its components through pattern recognition receptors (PRRs), for example, Toll-like receptors and protease-acti vated receptors. Ligation of PRRs induces downstream-signaling pathways modifying the activity of transcription factors that regulates the expression of genes linked to inflamma tion. This is followed by the release of inflammatory mediators, for example, cytokines and reactive oxygen species. Periodontal disease is today considered to play a significant role in various systemic conditions such as cardiovascular disease (CVD). The mechanisms by which P. gingivalis and its virulence factors interact with host immune cells and contribute to the pathogenesis of periodontitis and CVD are far from completely understood.

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Section: Periodontitis Systemic Inflammation and Cardiovascular Dismentioning

confidence: 85%

Section: Periodontitis Systemic Inflammation and Cardiovascular Dismentioning

confidence: 99%

Cellular Response Mechanisms in Porphyromonas gingivalis Infection

Khalaf¹,

Palm²,

Bengtsson³

2017

Periodontitis - A Useful Reference

View full text Add to dashboard Cite

show abstract

“…8,20 Periopathogens may cause inflammatory responses due to the complex reactions they instigate. 5,10,21 Literature reports support a moderate but significant association between periodontial disease and atherosclerotic vascular disease. What is more, treatment of periodontal diseases, including a control of periodontal infections, results in improved levels of markers of systemic inflammation and endothelial dysfunction.…”

Section: Discussionmentioning

confidence: 98%

“…3 Transient bacteremia can not only be related to periodontal surgical procedures but can also result from daily activities such as chewing, tooth brushing, and flossing. 4,5 There is evidence for a link between oral and general health, particularly regarding periodontitis and atherosclerosis, aortic intimal hyperplasia (cardiovascular lesions), diabetes, respiratory diseases, preterm and low birth weight delivery, preeclampsia, and inflammatory bowel disease. 4,6,7 As an association between general diseases and periodontitis was found, the term "periodontal syndrome" was introduced as a "risk indicator" or a "marker", which should be considered in prophylaxis and management of general health.…”

Section: Introductionmentioning

confidence: 99%

“…The evaluation of correlation between the presence of P. gingivalis in periodontal pockets and in heart valves may aid in the understanding of the role of this bacterial species in inflammatory or degenerative processes involving heart valves. P. gingivalis has been identified in the atherosclerotic plaque 5 and it is reasonable to assume that their presence could cause inflammatory processes in heart valves too. In such a case, a new link between atherosclerosis and calcific valve degeneration could be found.…”

Section: Introductionmentioning

confidence: 99%

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