<i>Porphyromonas gingivalis</i>in periodontal pockets and heart valves

Radwan-Oczko, Małgorzata; Jaworski, Aleksander; Duś, Irena; Płonek, Tomasz; Szulc, Małgorzata; Kustrzycki, Wojciech

doi:10.4161/viru.28657

Cited by 16 publications

(12 citation statements)

References 37 publications

(47 reference statements)

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“…P. gingivalis is one of the major pathogens implicated in chronic periodontitis, and 88% of the subjects with severe periodontitis were P. gingivalis (+) in this study. Recently, P. gingivalis has emerged as a target bacterium for explaining the relationship between periodontal and systemic diseases [ 27 28 ] and has been suggested to be a pathogen responsible for the propagation of rheumatoid arthritis (RA) [ 29 30 ]. P. gingivalis is the only known pathogen expressing peptidylarginine deiminase, which induces adaptive immune responses, including the production of anti-citrullinated peptide antibody, which is exclusive to RA [ 31 32 ].…”

Section: Discussionmentioning

confidence: 99%

Periodontal inflamed surface area as a novel numerical variable describing periodontal conditions

Park

Ahn

Lee

et al. 2017

J Periodontal Implant Sci

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PurposeA novel index, the periodontal inflamed surface area (PISA), represents the sum of the periodontal pocket depth of bleeding on probing (BOP)-positive sites. In the present study, we evaluated correlations between PISA and periodontal classifications, and examined PISA as an index integrating the discrete conventional periodontal indexes.MethodsThis study was a cross-sectional subgroup analysis of data from a prospective cohort study investigating the association between chronic periodontitis and the clinical features of ankylosing spondylitis. Data from 84 patients without systemic diseases (the control group in the previous study) were analyzed in the present study.ResultsPISA values were positively correlated with conventional periodontal classifications (Spearman correlation coefficient=0.52; P<0.01) and with periodontal indexes, such as BOP and the plaque index (PI) (r=0.94; P<0.01 and r=0.60; P<0.01, respectively; Pearson correlation test). Porphyromonas gingivalis (P. gingivalis) expression and the presence of serum P. gingivalis antibodies were significant factors affecting PISA values in a simple linear regression analysis, together with periodontal classification, PI, bleeding index, and smoking, but not in the multivariate analysis. In the multivariate linear regression analysis, PISA values were positively correlated with the quantity of current smoking, PI, and severity of periodontal disease.ConclusionsPISA integrates multiple periodontal indexes, such as probing pocket depth, BOP, and PI into a numerical variable. PISA is advantageous for quantifying periodontal inflammation and plaque accumulation.

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Section: Discussionmentioning

confidence: 99%

Periodontal inflamed surface area as a novel numerical variable describing periodontal conditions

Park

Ahn

Lee

et al. 2017

J Periodontal Implant Sci

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“…Nevertheless, another study detected none of the eight periodontal pathogens tested, including P. gingivalis , in whole blood and stenotic aortic valves, indicating absence from blood stream and lack of colonization of the valves 14 . The study from Radwan-Oczko et al, featured in the present issue of Virulence , employed a patient population with calcific heart valve degeneration and mild periodontitis 15 . They also did not detect P. gingivalis in any aortic or mitral valve specimens tested, although this species was present in 50% of the periodontal pockets of the corresponding patients.…”

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confidence: 79%

Porphyromonas gingivalis

2014

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“…The polymerase chain reaction (PCR) was described in detail in the publication by Radwan-Oczko et al [20]. The mixture obtained from the PCR was subjected to electrophoresis.…”

Section: Detection Of Porphyromonas Gingivalis Dnamentioning

confidence: 99%

Periodontal disease and influence of periodontal treatment on disease activity in patients with rheumatoid arthritis and spondyloarthritis

et al. 2019

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The aim of this study was to assess the prevalence of periodontal disease and the effect of periodontal treatment in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA). Forty-four RA patients, thirty SpA patients and thirty-nine healthy volunteers were recruited to the study. Periodontal examination included the approximal plaque index (API), bleeding on probing (BoP), probing depth (PD) and number of teeth. Samples from the deepest periodontal pockets were taken for the detection of Porphyromonas gingivalis DNA with the use of the polymerase chain reaction. All subjects with periodontitis, who completed the study, received periodontal treatment consisting of scaling/root planing and oral hygiene instructions. Disease activity scores, clinical and laboratory parameters were assessed before and 4-6 weeks after periodontal treatment. No significant difference in the prevalence of periodontal disease and the presence of P. gingivalis DNA were found in RA and SpA patients compared to healthy controls. Significantly higher API (80% vs 63%; p = 0.01) and a lower number of teeth (20 vs 25, p = 0.001) were found in RA patients. BoP was significantly elevated in SpA patients (51% vs 33%, p = 0.02). Disease activity measured by the DAS28(CRP) was significantly reduced in RA patients after periodontal treatment (p = 0.002). Clinical and biochemical parameters were not improved in SpA patients. Nonsurgical periodontal treatment had an impact on the decrease in RA activity. Periodontal examination is necessary in patients with RA to detect and treat periodontitis at an early stage.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Porphyromonas gingivalisin periodontal pockets and heart valves

Cited by 16 publications

References 37 publications

Periodontal inflamed surface area as a novel numerical variable describing periodontal conditions

Periodontal inflamed surface area as a novel numerical variable describing periodontal conditions

Porphyromonas gingivalis

Periodontal disease and influence of periodontal treatment on disease activity in patients with rheumatoid arthritis and spondyloarthritis

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