Molecular Diagnostics in the Neoplasms of Small Intestine and Appendix

Zhang, Yingtao; Zulfiqar, Muhammad; Bluth, Martin H.; Bhalla, Amarpreet; Beydoun, Rafic

doi:10.1016/j.cll.2018.03.002

Cited by 8 publications

(8 citation statements)

References 83 publications

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“…Our population shows that appendiceal tumors incidentally found in emergent appendectomies are signi cant, with an incidence of 2,14%, similar to those reported worldwide, between 0,2% and 2,5% (5,10,24). From 2012 to 2018, an increase in the number of new cases of appendiceal neoplasms was evidenced (Fig.…”

Section: Discussionsupporting

confidence: 81%

“…These neoplasms correspond to less than 0,5% of all tumors of the gastrointestinal tract (22,23), and are found in approximately 1% of the specimens from appendectomies (22)(23)(24). Its incidence is low but has increased as reported by different international series (8-10).…”

Section: Introductionmentioning

confidence: 97%

“…Its incidence is low but has increased as reported by different international series (8-10). Worldwide, it varies between 0,2% and 2,5% (5,10,24) (between 0,07% and 0,8% in Chile (10), 0,78% in Turkey ( 14), 0,9% in Spain (17), between 0,9% and 1,7% in the United States (6), 1,24% in Finland (5), 2,3% in Japan (8), and < 3% in Tunisia ( 15)). In Colombia, the incidence of tumors of the appendix is unknown.…”

Section: Introductionmentioning

confidence: 99%

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Incidence of Appendiceal Neoplasms in Appendectomy Patients

Girón

Núñez-Rocha²,

Rodríguez³

et al. 2023

Preprint

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BACKGROUND: Non-operative management has been suggested as a therapy for uncomplicated appendicitis. Notwithstanding, the risk of missing an appendiceal tumor must be considered, being the surgical piece crucial to rule out neoplasms. Therefore, we aim to determine the incidence of appendiceal neoplasms in patients with acute appendicitis, tumor types and the importance of the anatomopathological study of the surgical piece. STUDY DESIGN: Retrospective study with a prospective database in which we described patients who underwent emergent appendectomy with histopathological findings of appendiceal neoplasms from January 2012 to September 2018. Descriptive analysis included demographic variables, diagnostic methods, and surgical techniques. RESULTS: 2993 patients diagnosed with acute appendicitis who underwent an emergency appendectomy. 64 neoplasms of the appendix were found with an incidence of 2,14%. 67.2% were women, the mean age was 46,4 years (±19.5). The most frequent appendiceal neoplasms were neuroendocrine tumors (42,2%), followed by appendiceal mucinous neoplasms (35,9%), sessile serrated adenomas (18,8%), and adenocarcinomas (3,1%). In 89,1% of the cases, acute appendicitis was determined by imaging, and 14 % of cases were suspected intraoperatively. Appendectomy was performed in 78,1% without additional procedures. CONCLUSIONS: Appendiceal tumors are rare and must be ruled out in patients with suspected acute appendicitis. The incidence of incidental neoplasms is higher in this study than in the previously reported series. This information must be included in decision-making when considering treatment options for acute appendicitis.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Incidence of Appendiceal Neoplasms in Appendectomy Patients

Girón

Núñez-Rocha²,

Rodríguez³

et al. 2023

Preprint

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“…The small intestine is crucial for maintaining normal physiological activities of the human body and is responsible for the uptake, digestion and absorption of nutrients (28). The small intestine is also the largest reservoir of bacteria and endotoxins and a vital neuroendocrine and immune organ (29).…”

Section: Discussionmentioning

confidence: 99%

Remote ischemic post‑conditioning alleviates ischemia/reperfusion‑induced intestinal injury via the ERK signaling pathway‑mediated RAGE/HMGB axis

et al. 2021

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Intestinal ischemia reperfusion (I/R) injury is a tissue and organ injury that frequently occurs during surgery and significantly contributes to the pathological processes of severe infection, injury, shock, cardiopulmonary insufficiency and other diseases. However, the mechanism of intestinal I/R injury remains to be elucidated. A mouse model of intestinal I/R injury was successfully established and the model mice were treated with remote ischemic post-conditioning (RIPOC) and/or an ERK inhibitor (CC-90003), respectively. Histopathological changes of the intestinal mucosa were determined by hematoxylin and eosin staining. In addition, the levels of high-mobility group box 1 (HMGB1) and receptor for advanced glycation end products (RAGE) expression were confirmed by reverse transcription-quantitative polymerase chain reaction, western blotting and immunohistochemistry assays. The levels of antioxidants, oxidative stress markers (8-OHdG) and interleukin 1 family members were evaluated by ELISA assays and the levels of NF-κB pathway proteins were analyzed by western blotting. The data demonstrated that RIPOC could attenuate the histopathological features of intestinal mucosa in the intestinal I/R-injury mouse models via the ERK pathway. It was also revealed that HMGB1 and RAGE expression in the mouse models could be markedly reduced by RIPOC (P<0.05) and that these reductions were associated with inhibition of the ERK pathway. Furthermore, it was demonstrated that RIPOC produced significant antioxidant and anti-inflammatory effects following an intestinal I/R injury and that these effects were mediated via the ERK pathway (P<0.05). In addition, RIPOC was demonstrated to suppress the NF-κB (p65)/NLR family pyrin domain containing 3 (NLRP3) inflammatory pathways in the intestinal I/R injury mouse models via the ERK pathway. The findings of the present study demonstrated that RIPOC helped to protect mice with an intestinal I/R injury by downregulating the ERK pathway.

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“…There are a variety of pathological types of malignant PSIT. Adenocarcinoma is the most common pathological type, up to 40%, followed by neuroendocrine tumors (25%), malignant lymphomas (10%-15%) and malignant stromal tumors (9%)[ 86 ]. PSIT lacks specific manifestations in the early stage, and they are faced with many problems in the clinic, such as difficult diagnosis, high misdiagnosis rate, nonstandard treatment and so on[ 87 ].…”

Section: Ai In Common Small Intestinal Diseasesmentioning

confidence: 99%

Artificial intelligence in small intestinal diseases: Application and prospects

Yu¹,

Li²,

Yao³

et al. 2021

WJG

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The small intestine is located in the middle of the gastrointestinal tract, so small intestinal diseases are more difficult to diagnose than other gastrointestinal diseases. However, with the extensive application of artificial intelligence in the field of small intestinal diseases, with its efficient learning capacities and computational power, artificial intelligence plays an important role in the auxiliary diagnosis and prognosis prediction based on the capsule endoscopy and other examination methods, which improves the accuracy of diagnosis and prediction and reduces the workload of doctors. In this review, a comprehensive retrieval was performed on articles published up to October 2020 from PubMed and other databases. Thereby the application status of artificial intelligence in small intestinal diseases was systematically introduced, and the challenges and prospects in this field were also analyzed.

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Molecular Diagnostics in the Neoplasms of Small Intestine and Appendix

Cited by 8 publications

References 83 publications

Incidence of Appendiceal Neoplasms in Appendectomy Patients

Incidence of Appendiceal Neoplasms in Appendectomy Patients

Remote ischemic post‑conditioning alleviates ischemia/reperfusion‑induced intestinal injury via the ERK signaling pathway‑mediated RAGE/HMGB axis

Artificial intelligence in small intestinal diseases: Application and prospects

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