Molecular Determinants of Tooth Development: A Review

Slavkin, Harold C.

doi:10.1177/10454411900010010201

Cited by 44 publications

(20 citation statements)

References 85 publications

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“…Enamel formation originates from interactions between ectoderm-derived oral epithelium and neural crest-derived ectomesenchyme [31-33]. During the early stages of enamel formation, the dental epithelium is in contact with the basement membrane, a proteinaceous matrix responsible for providing critical signals to direct cellular proliferation and differentiation mediated in part through cell-based integrin receptors [34, 35].…”

Section: Introductionmentioning

confidence: 99%

Biological synthesis of tooth enamel instructed by an artificial matrix

et al. 2010

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The regenerative capability of enamel, the hardest tissue in the vertebrate body, is fundamentally limited due to cell apoptosis following maturation of the tissue. Synthetic strategies to promote enamel formation have the potential to repair damage, increase the longevity of teeth and improve the understanding of the events leading to tissue formation. Using a self-assembling bioactive matrix, we demonstrate the ability to induce ectopic formation of enamel at chosen sites adjacent to a mouse incisor cultured in vivo under the kidney capsule. The resulting material reveals the highly organized, hierarchical structure of hydroxyapatite crystallites similar to native enamel. This artificially triggered formation of organized mineral demonstrates a pathway for developing cell fabricated materials for treatment of dental caries, the most ubiquitous disease in man. Additionally, the artificial matrix provides a unique tool to probe cellular mechanisms involved in tissue formation further enabling the development of tooth organ replacements.

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Section: Introductionmentioning

confidence: 99%

Biological synthesis of tooth enamel instructed by an artificial matrix

et al. 2010

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“…Cell/cell and cell/matrix interactions control tooth morphogenesis and odontoblast differentiation (Kollar, 1983;Ruch, 1985;Slavkin, 1990;Thesleff and Vaahtokari, 1992;Ruch et al, 1995). In mature teeth, the absence of inductive epithelium and the related basement membrane, initially required, indicates that the secretion of reactionary or reparative dentin, respectively, by odontoblasts or odontoblast-like cells may be triggered by the release of appropriate active molecules during tissue damage (from, e.g., caries or restorative procedures).…”

Section: Introductionmentioning

confidence: 99%

An in vitro Model of Human Dental Pulp Repair

Magloire¹,

Joffre²,

Bleicher³

1996

J Dent Res

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Abstract. Pulp tissue responds to dentin injury by laying down reactionary dentin secreted by existing odontoblasts or reparative dentin elaborated by odontoblast-like cells that differentiated from precursor cells in the absence of inner dental epithelium and basement membrane. Furthermore, growth factors or active dentin matrix components are fundamental signals involved in odontoblast differentiation. In vitro, dental pulp cells cultured under various conditions are able to express typical markers of differentiation, but no culture system can re-create pulp response to dentin drilling. This paper reports the behavior of thick slices from human teeth drilled immediately after extraction and cultured from 3 days to 1 month. Results show that the damaged pulp beneath the cavity is able to develop, in vitro, some typical aspects correlated to tissue healing, evidenced by cell proliferation (BrdU-positive cells), neovascularization (positive with antitype-IV collagen antibodies), and the presence of functional (3H proline-positive) cuboidal cells close to the injured area.After 30 days of culture, elongated spindle-shaped cells can be seen aligned along the edges of the relevant dentin walls, whereas sound functional odontoblasts are well-preserved beneath healthy areas. This tissue recovery leads us to believe that such a culture model will be a useful system for testing factors regulating pulp repair.

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“…Furthermore, cell-to-cell and cell-matrix signalling pathways and related target nuclear factors have been identified as mediators of reciprocal communication between dental epithelial and mesenchymal cells (reviewed by Ruch, 1985;Slavkin, 1990;Jernval and Thesleff, 2000;Thesleff and Mikkola, 2002;Thesleff, 2003).…”

Section: Enamel Epithelium: the Histogenesis Of The Hardest Tissuementioning

confidence: 99%

The Fathers of Italian Histology

ISH¹

2009

Eur J Histochem

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Subscriptions, cancellations, business correspondence and any enquiries must be sent to the Tipografia PIME Editrice srl, Pavia, Italy. Cancellations must be received before the end of September to take effect at the end of the same year.No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means (electronic, electrostatic, magnetic type, mechanical, photocopying or otherwise) without written permission by the Publishers.Reg. Tribunale di Pavia n. 289/23.2.1984. Supported by the Ministero per i Beni e le Attività Culturali, Italy as a publication of high cultural value.Associato all'USPI Unione Stampa Periodica Italiana Disclaimer. Whilst every effort is made by the publishers and the editorial board to see that no inaccurate or misleading data, opinion or statement appears in this journal, they wish to make it clear that the data and opinions appearing in the articles or advertisements herein are the responsibility of the contributor or advisor concerned. Accordingly, the publisher, the editorial board and their respective employees, officers and agents accept no liability whatsoever for the consequences of any inaccurate or misleading data, opinion or statement. The Journal publishes original papers, technical reports, letters to the editor, review articles concerning investigations performed with the aid of biophysical, biochemical, molecular-biological, enzymatic, immunohistochemical, cytometric, and image analysis techniques. Areas of particular interest to the European Journal of Histochemistry include: -functional cell and tissue biology in animals and plants; -cell differentiation and death; -cell-cell interaction and molecular trafficking; -biology of cell development and senescence; -nerve and muscle cell biology; -cellular basis of diseases During this period, Carlo Rizzoli established the experimental approach for the study of the molecular basis of cell differentiation in vitro, anticipating some aspects of the present investigation on the potentiality of stem cells. Furthermore, Carlo Rizzoli was one of the first Italian scientists to publish its scientific reports in large-diffusion international journals, thus contributing to the world-wide diffusion of the seminal studies on the in vitro cell differentiation models. Editor-in-ChiefIn 1961, Carlo Rizzoli became Professor of Histology and general embryology and, since 1964 to 1999, Director of the Institute of Histology at the University of Bologna.The initial steps of this undertaking were challenging, since in 1963, following the recruitment of Oliviero Mario Olivo at the Chair of Human Anatomy, the facilities of the Institute of Histology were almost nonexistent. In few years, however, Carlo Rizzoli was able to organize an efficient research group of motivated young collaborators that included Paolo Carinci, Lia Guidotti, Francesco Antonio Manzoli, capable of introducing original and seminal lines of research into the national and international histological arena. In this way, a numb...

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Molecular Determinants of Tooth Development: A Review

Cited by 44 publications

References 85 publications

Biological synthesis of tooth enamel instructed by an artificial matrix

Biological synthesis of tooth enamel instructed by an artificial matrix

An in vitro Model of Human Dental Pulp Repair

The Fathers of Italian Histology

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